I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
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Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#2The limiting factor in drug development is not creating the drug, but in testing it. I'd like to see a biohacking approach to drug testing.
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#3> All three of us developed SARS-CoV2 spike protein neutralizing antibodies. I still can't fucking believe it. Not only did we create and test a successful vaccine, we showed that we could get a gene therapy to work (a DNA vaccine changes the DNA in your cells and so is a gene therapy also)
Seems incredibly dangerous. What if 3 years from now, he realizes the changes he made are crashing his immune system? There is no "undo" button.
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#4Can any biologist confirm there is some actual science going on there? (otherwise, we should flag this).
The live-stream is no longer available. The main documentary output seems to be here https://drive.google.com/drive/folders/1SracILuRbiZt4f7EVH2J...
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#5Here is where I immediately have a red flag from the author:
"sometimes I hide the fact that I have PhD because I don't want it to be a symbol of authority or intelligence for myself"
yet, at the top of the site "Josiah Zayner, PhD"."
well, which one is it Josiah?
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#6The limiting factor in drug development is not creating the drug, but in testing it. I'd like to see a biohacking approach to drug testing.
When Jenner created (really discovered) the original SmallPox vaccine, he basically just inoculated people with Cowpox and Horsepox. That was over 180 years ago. There were no phases, clinical trials or testing standards back then. Real medicine and snake oil were difficult, if not impossible, to distinguish.
Before Jenner, there were groups inoculating people with actual Smallpox (typically in the nose, because it was quicker to recover from). The Chinese started doing that 500 years ago, and it was even used by troops in the American revolutionary war. Some of those people would die of course, but the ones who recovered would have an immunity.
A lot of people may have died from many of these early tests, but so many people were dying it didn't quite matter.
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#7This was flagged (I don't know why), but it seems like a very interesting article to me and would like to read the discussion here, so I vouched for it. I don't know enough about the science to opine on the content, but I think it's worth a second chance.
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#8Can any biologist confirm there is some actual science going on there? (otherwise, we should flag this). The live-stream is no longer available. The main documentary output seems to be here https://drive.google.com/drive/folders/1SracILuRbiZt4f7EVH2J...
Yes, the sequences are available [1] and well within the capabilities of a hobbyist with a little gumption - all they're using is commercial off the shelf services available to any researcher or student.
Whether its good science or not is beyond my understanding of this particular subject. It's definitely not usable for any sort of premarketing approval.
[1] https://docs.google.com/document/d/1Q18Sh-67NigwabhxBQAtLfRq...
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#9This sentiment is not unique to biomedicine. It's pretty often you see people finger elitism or capitalism for screwing people over because "I can make it myself."
Ethically, you are more than welcome to experiment on yourself. That's your prerogative. But, as has already been expressed here, the issue is once you start giving your creation to others. Even when the science is conceptually very simple, like in the case of nucleic acid vaccines, a huge number of variables can impact the safety and efficacy endpoints for the recipient. That's why trials and regulation are essential.
Are these regulatory systems perfect? Absolutely not (they are in dire need of reform). But they form an essential safety barrier for the general public. Decrying them as class warfare is incredibly naive.
Re: I Made a Covid-19 Vaccine in My Kitchen and It Worked – Science Still Sucks
#10Here is where I immediately have a red flag from the author: "sometimes I hide the fact that I have PhD because I don't want it to be a symbol of authority or intelligence for myself" yet, at the top of the site "Josiah Zayner, PhD"." well, which one is it Josiah?
sometimes != always
makes sense that he would want to strengthen his credibility in an article like this, no?