Biomarker of Alzheimer's found to be regulated by sleep cycles

I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep.

I highly suggest reading the book to explore more about your sleep.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#5

Post by yunesj » Thu, Dec 17, 2020, 5:01 PM UTC

That’s not surprising at all. From a paper on circadian expression:

> We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an organ-specific manner.

Assuming they looked at more than one protein biomarker, it’s highly likely that one of them would have circadian expression.

https://www.pnas.org/content/111/45/16219

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#6

Post by Zenst » Thu, Dec 17, 2020, 5:04 PM UTC

0xcafecafe wrote: post #2

I wonder if there are studies linking this disease to occupations which routinely disturb ones circadian rhythm like air travel.

Certainly been ones looking at effects of lack of sleep and this jumped out: https://www.nih.gov/news-events/nih-research-matters/sleep-d...

Like most thinks, they have an effect and increase the odds, don't guarantee that lack of sleep during your life will assure you get it, just increases the chances as does age, which maybe a factor with such occupations you mention.

I'd imagine shift workers would be a source of study about sleep impact.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#7

Post by crusso » Thu, Dec 17, 2020, 5:05 PM UTC

Brajeshwar wrote: post #4

I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep. I highly suggest reading the book to explore more about your sleep.

I got that book based upon a HN recommendation. It's fascinating reading and made me think carefully about how much sleep I was getting.

I used to think of sleep as something that I could put off on a whim and catch-up on over the weekend. I would stay up later to play video games or program if I felt like it. Now, I'm a lot more rigorous in keeping to my nighttime sleep schedule. Whatever I'm doing can normally wait until the next day.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#8

Post by remote_phone » Thu, Dec 17, 2020, 5:05 PM UTC

My mother has dementia, and I know 5 other close friends that are starting to deal with it as well. This is becoming an epidemic and what people don’t realize is that it is extremely expensive and exceedingly cruel. Most health care systems, including Canada and the US, do not handle dementia well at all. You have the choice of becoming financially destitute keeping your parents in a dignified setting, or you can let them essentially rot in a public facility which is basically a hospital. It’s terrible and needs a better solution.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#9

Post by sicromoft » Thu, Dec 17, 2020, 5:07 PM UTC

Brajeshwar wrote: post #4

I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep. I highly suggest reading the book to explore more about your sleep.

Be warned, that book is riddled with scientific and factual errors: https://guzey.com/books/why-we-sleep/

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#10

Post by hyldmo » Thu, Dec 17, 2020, 5:08 PM UTC

sicromoft wrote: post #9

Brajeshwar wrote: post #4

I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep. I highly suggest reading the book to explore more about your sleep.

Be warned, that book is riddled with scientific and factual errors: https://guzey.com/books/why-we-sleep/

HN thread on guzey's article: https://news.ycombinator.com/item?id=21546850