Oxford University breakthrough on global COVID-19 vaccine
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Re: Oxford University breakthrough on global COVID-19 vaccine
#2"These preliminary data indicate that the vaccine is 70.4% effective, with tests on two different dose regimens showing that the vaccine was 90% effective if administered at a half dose and then at a full dose, or 62% effective if administered in two full doses."
Re: Oxford University breakthrough on global COVID-19 vaccine
#3"These preliminary data indicate that the vaccine is 70.4% effective, with tests on two different dose regimens showing that the vaccine was 90% effective if administered at a half dose and then at a full dose, or 62% effective if administered in two full doses."
Does anyone here who understands vaccines know how starting with a smaller does can improve effectiveness? It goes against my intuition.
Re: Oxford University breakthrough on global COVID-19 vaccine
#4"These preliminary data indicate that the vaccine is 70.4% effective, with tests on two different dose regimens showing that the vaccine was 90% effective if administered at a half dose and then at a full dose, or 62% effective if administered in two full doses."
Does anyone here who understands vaccines know how starting with a smaller does can improve effectiveness? It goes against my intuition.
I wonder what the statistical significance is of those findings. I seems to me that they tried out various different approaches, so the sub-group that received this first-low-second-high treatment might be considerably smaller than the other groups combined leading to slightly less certainty in regards to the findings.
Re: Oxford University breakthrough on global COVID-19 vaccine
#5The key differentiator here is the storage requirements (2-8c ‘normal refrigerator’).
That’s much more accessible to developing / low GDP countries as opposed the cumbersome and expensive storage requirements of the other two.
Re: Oxford University breakthrough on global COVID-19 vaccine
#6The press release is interesting. Not the best way to present their data. Immediate conclusion of many newspapers is "oxford vaccine is less effective then...".
Re: Oxford University breakthrough on global COVID-19 vaccine
#7over 7 billion human population, a 90% effectiveness is what? alright? please enlighten me. does anyone know what was the effectiveness of the smallpox vaccine that we did actually manage to eradicate successfully?
Re: Oxford University breakthrough on global COVID-19 vaccine
#8That headline is not quite correct. From the article:
> Phase 3 interim analysis including 131 Covid-19 cases indicates that the vaccine is [on average] 70.4% effective when combining data from two dosing regimens ... In the two different dose regimens vaccine efficacy was 90% in one and 62% in the other
And to be clear, it's not just one dose vs two:
> tests on two different dose regimens showing that the vaccine was 90% effective if administered at a half dose and then at a full dose, or 62% effective if administered in two full doses.
So "Oxford vaccine is up to 90% effective", perhaps?
Re: Oxford University breakthrough on global COVID-19 vaccine
#9over 7 billion human population, a 90% effectiveness is what? alright? please enlighten me. does anyone know what was the effectiveness of the smallpox vaccine that we did actually manage to eradicate successfully?
this is different for each disease based on how quickly it transmits.
for SARS-COV-2 you need around 70% immunity in the population to achieve herd immunity
Re: Oxford University breakthrough on global COVID-19 vaccine
#10I think I read (and I may be wrong) that the costs for the vaccines per dose were roughly as follows:
Moderna: £45, Pfizer: £20, Oxford: £3,
The Oxford one is also easier to store and transport.