Poor Sleep Linked with Future Amyloid-β Build Up
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Poor Sleep Linked with Future Amyloid-β Build Up
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Re: Poor Sleep Linked with Future Amyloid-β Build Up
#2People will be tempted to infer causation here, but it's important to note that no evidence of causation is presented. It is most likely that some third condition causes both poor sleep and amyloid-b accumulation (since correlation usually doesn't indicate causation).
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#3Great, another thing insomniacs can lie awake worried about!
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#4People will be tempted to infer causation here, but it's important to note that no evidence of causation is presented. It is most likely that some third condition causes both poor sleep and amyloid-b accumulation (since correlation usually doesn't indicate causation).
Yeah, but that's true with all long term nutrition and lifestyle studies, since it's impossible to test for causation with any degree of rigor (I don't even know what a long term double blind study would look like).
So, yes, correlation does not imply causation; it does still imply correlation. Even if a third variable, if you're getting poor sleep, you're more likely to have higher Amyloid-β build up
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#5People will be tempted to infer causation here, but it's important to note that no evidence of causation is presented. It is most likely that some third condition causes both poor sleep and amyloid-b accumulation (since correlation usually doesn't indicate causation).
Yeah, but that's true with all long term nutrition and lifestyle studies, since it's impossible to test for causation with any degree of rigor (I don't even know what a long term double blind study would look like). So, yes, correlation does not imply causation; it does still imply correlation. Even if a third variable, if you're getting poor sleep, you're more likely to have higher Amyloid-β build up
establishing causation is not impossible, just hard.
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#6Great, another thing insomniacs can lie awake worried about!
You joke, but my mum's mind has died from Alzheimer's and I'm literally having anxiety attacks induced from that leaving me to extremely poor sleep patterns.
Her father had Alzheimer's (undiagnosed AFAIK), and my mum had poor sleep patterns for sure (though not as bad as mine are, I think).
If there's truth in this then somewhat ironically, yes, there's a perpetuation there.
Sorry, to bring the town down.
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#7Based on this, if you are at risk for Alzheimers (your 23andme report shows this), then one of the most important things you can do today is to religiously track your sleep and make sure you get enough deep sleep daily.
In my anecdotal experience, if you don't get enough deep sleep for a sustained period of time, you start showing minor cognitive defects - e.g mixing up words, not being able to write long, irritability. Tracking sleep and 'catching up' makes all this go away.
This is especially important for people who are caffeine sensitive, but drink a lot of caffeine. You end up getting 5-6 hours of sleep nightly, and have this constantly mounting cumulative sleep deficit.
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#8Based on this, if you are at risk for Alzheimers (your 23andme report shows this), then one of the most important things you can do today is to religiously track your sleep and make sure you get enough deep sleep daily. In my anecdotal experience, if you don't get enough deep sleep for a sustained period of time, you start showing minor cognitive defects - e.g mixing up words, not being able to write long, irritabili…
I understand your desire to help here but it's important to understand these kinds of attitudes can be counter-productive. My saving grace after several months of difficulty sleeping a decade ago was a book called "Say Goodnight to Insomnia" where they systematically break down why most of what you've written here is incorrect. Within a week of reading the book breaking away from many believing many of the things you've written above I was finally able to sleep well and have ever since.
From the description:
My insomnia program achieves its remarkable results because it is based on a simple yet powerful concept: insomnia can only be treated by addressing all the underlying causes. In most instances, the causes of insomnia are thoughts and behaviors (habits) that are learned and can be unlearned. Some examples include: - Attitudes and beliefs about sleep - Negative, stressful thoughts about insomnia - Feelings of loss of control over sleep - Inadequate exercise or exposure to sunlight - Going to bed too early or sleeping too late - Trying to control sleep rather than letting it occur naturally - Negative responses to stress - Lying awake in bed, frustrated and tense
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#9I'll just note that the link between amyloid and alzheimers isn't concrete and is actually an incredibly controversial area of research[0]. The most recent attempt at treating alzheimers via amyloid is not going so well[1]. So, the causality implied by this article (poor sleep -> amyloid buildup -> alzheimers) isn't necessarily on the strongest theoretical footing.
[0]https://www.nature.com/articles/d41586-018-05719-4
[1]https://www.sciencemag.org/news/2020/11/biogen-s-alzheimer-s...
Re: Poor Sleep Linked with Future Amyloid-β Build Up
#10People will be tempted to infer causation here, but it's important to note that no evidence of causation is presented. It is most likely that some third condition causes both poor sleep and amyloid-b accumulation (since correlation usually doesn't indicate causation).
"It is most likely that ..."
I agree with your main point and was going to write something like this. But "most likely" is likely unjustified. It could be a 3rd factor that causes both, but its likelihood is unknown.