Caffeine enhances activity of common antidepressants in forced swim test in mice
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Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#2Full title gives a bit more context: "Caffeine enhances the antidepressant-like activity of common antidepressant drugs in the forced swim test in mice."
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#3I was under the impression that this is a pretty known effect. I used to take anti-depressants along with CNS stimulants and this definitely was something that my psychiatrist and my other doctors mentioned to me and considered when choosing an appropriate dosage.
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#4My perfect day is 8 hours of caffeine, an hour at the gym, 4 hours of alcohol, SSRI for a nightcap. YMMV
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#5I was under the impression that this is a pretty known effect. I used to take anti-depressants along with CNS stimulants and this definitely was something that my psychiatrist and my other doctors mentioned to me and considered when choosing an appropriate dosage.
Can you expound on that? Can you paraphrase the doctor's suggestions?
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#6My perfect day is 8 hours of caffeine, an hour at the gym, 4 hours of alcohol, SSRI for a nightcap. YMMV
Selective serotonin reuptake inhibitors (SSRIs)
boclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#7My perfect day is 8 hours of caffeine, an hour at the gym, 4 hours of alcohol, SSRI for a nightcap. YMMV
I hope you're exaggerating - that kind of cocktail is going to kill your sleep quality and, in the long-term, quite possibly fry your brain.
Thumbs up on the exercise though.
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#8They don't appear to have run a control with caffeine alone. Caffeine is a well-established athletic performance-enhancing drug in its own right. Isn't this a serious flaw with the swim-test portion of this study?
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#9My perfect day is 8 hours of caffeine, an hour at the gym, 4 hours of alcohol, SSRI for a nightcap. YMMV
It should go without saying that YMMV if you keep that up.
Re: Caffeine enhances activity of common antidepressants in forced swim test in mice
#10My perfect day is 8 hours of caffeine, an hour at the gym, 4 hours of alcohol, SSRI for a nightcap. YMMV
I'd strongly recommend L-Theanine if you'd like to not need as much caffeine or alcohol.