Has esketamine been overhyped?
gq-magazine.co.uk
Has esketamine been overhyped?
1–10 of 51 posts
Re: Has esketamine been overhyped?
#2There's nothing wrong with bolstering the Psychiatrist's armamentarium with a novel drug that could help with clinical edge-cases of depression. This article was unfairly biased.
Re: Has esketamine been overhyped?
#3There's nothing wrong with bolstering the Psychiatrist's armamentarium with a novel drug that could help with clinical edge-cases of depression. This article was unfairly biased.
“the FDA set a worrisome new precedent by allowing Janssen to use a “withdrawal” study as its second “positive” study. These studies tend to be slanted in favour of the test drug because they only consist of patients who responded well to the drug in the short-term trials. For this reason, they have never previously been deemed adequate in satisfying FDA requirements.”
Sounds pretty damning
Re: Has esketamine been overhyped?
#4There's nothing wrong with bolstering the Psychiatrist's armamentarium with a novel drug that could help with clinical edge-cases of depression. This article was unfairly biased.
And why not just regular old ketamine instead of a dangerous, untested new derivative? The whole system is broken beyond repair.
Re: Has esketamine been overhyped?
#5There's nothing wrong with bolstering the Psychiatrist's armamentarium with a novel drug that could help with clinical edge-cases of depression. This article was unfairly biased.
"Could" is nowhere close to good enough for a drug with potentially serious side-effects.
Re: Has esketamine been overhyped?
#6There's nothing wrong with bolstering the Psychiatrist's armamentarium with a novel drug that could help with clinical edge-cases of depression. This article was unfairly biased.
The article has a pretty balanced view and several of the people asked say that esketamine could have some benefit for some patients.
But other than that your statement doesn't make a lot of sense. Of course there can be everything wrong with a novel drug that "could" help with edge-cases. Because if you don't know if it helps and if it may harm people - it could very well do more harm than good. That's why we want robust science for new drugs: To decide whether they'll help more than harm.
Re: Has esketamine been overhyped?
#7Holy shit:
> there are concerns about the drug’s withdrawal effects after three of the study’s participants committed suicide within 20 days of its end
It doesn't say how many people committed suicide from the control group, but regardless, 3 suicides sounds pretty bad for an anti-depressant. Who would approve a drug like this?
The cynic in me says an addictive drug with severe withdrawal effects is exactly what pharma companies want...
Re: Has esketamine been overhyped?
#8[deleted]
Re: Has esketamine been overhyped?
#9Holy shit: > there are concerns about the drug’s withdrawal effects after three of the study’s participants committed suicide within 20 days of its end It doesn't say how many people committed suicide from the control group, but regardless, 3 suicides sounds pretty bad for an anti-depressant. Who would approve a drug like this? The cynic in me says an addictive drug with severe withdrawal effects is exactly what phar…
The question about the control group is pretty important because the test subjects had to severely depressed to qualify (I believe)
Re: Has esketamine been overhyped?
#10Holy shit: > there are concerns about the drug’s withdrawal effects after three of the study’s participants committed suicide within 20 days of its end It doesn't say how many people committed suicide from the control group, but regardless, 3 suicides sounds pretty bad for an anti-depressant. Who would approve a drug like this? The cynic in me says an addictive drug with severe withdrawal effects is exactly what phar…
The drug is licensed for people with treatment resistant depression. This group has significantly higher risk of death by suicide. I dislike speculating on causes of suicides, but if they've been told "here's this thing that appears to give relief from depression for people like you", and they try it, and it doesn't, I can see how that would further increase their risk.