Evolutionary gene loss may explain why only humans are prone to heart attack
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Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#2I like how the headlines explicitly states humans.
For yet another study in ... mice.
There are other options like dogs and pigs which are much better models for human biology, so if you really want to make a claim about subtle effects of human genetics you need to be as close to a human model as possible.
This is entirely ignoring the someone generous leap they make that one single gene mutation is responsible for an increased rate of heart disease. It also doesn’t touch on what the benefits for that gene were (to spread through the gene pool completely it must have some benefit that outweighs the cost)
Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#3I like how the headlines explicitly states humans . For yet another study in ... mice. There are other options like dogs and pigs which are much better models for human biology, so if you really want to make a claim about subtle effects of human genetics you need to be as close to a human model as possible. This is entirely ignoring the someone generous leap they make that one single gene mutation is responsible for…
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Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#4I like how the headlines explicitly states humans . For yet another study in ... mice. There are other options like dogs and pigs which are much better models for human biology, so if you really want to make a claim about subtle effects of human genetics you need to be as close to a human model as possible. This is entirely ignoring the someone generous leap they make that one single gene mutation is responsible for…
Further down in the study it says that removing the gene likely occurred because it made humans more resistant to malaria, and somehow it also enhanced the ability to run long distances.
Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#5Since the driver of the selection against the related gene seems to be malaria, I wonder if this is linked to prevalence of body hair on human ancestors.
Bug bites on hairless skin probably had something to do with dying of disease, and the early homonids that had the gene seem to be the ones hit the hardest.
We also see evolutionary markers related to bed bugs, head lice and body lice. Maybe mosquitos and genes linked to a possible malaria pandemic offer more clues.
Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#6I like how the headlines explicitly states humans . For yet another study in ... mice. There are other options like dogs and pigs which are much better models for human biology, so if you really want to make a claim about subtle effects of human genetics you need to be as close to a human model as possible. This is entirely ignoring the someone generous leap they make that one single gene mutation is responsible for…
If this withstands scrutiny a chimpanzee study can't be far off, though.
Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#7I like how the headlines explicitly states humans . For yet another study in ... mice. There are other options like dogs and pigs which are much better models for human biology, so if you really want to make a claim about subtle effects of human genetics you need to be as close to a human model as possible. This is entirely ignoring the someone generous leap they make that one single gene mutation is responsible for…
At this point this is only a hypothesis. This is clear when they say "may help explain", "may have resulted", and "believe".
Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#8Since the driver of the selection against the related gene seems to be malaria, I wonder if this is linked to prevalence of body hair on human ancestors. Bug bites on hairless skin probably had something to do with dying of disease, and the early homonids that had the gene seem to be the ones hit the hardest. We also see evolutionary markers related to bed bugs, head lice and body lice. Maybe mosquitos and genes link…
Malaria is a fascinating one, with the prevalence of sickle cell anemia and G6PD blood deficiency in some populations with high exposure. Both of those cause health issues but they both confer some level of resistance to malaria.
Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#9I wonder if a gone lost hundreds of years ago is somehow _responsible_, then why heart attack related death mostly occured in last 50 years?
Re: Evolutionary gene loss may explain why only humans are prone to heart attack
#10Linus Pauling figured out almost 30 years ago why humans are prone to heart attacks, and not only did he discover why, he also has a mechanism by which to reverse existing heart disease and prevent heart attacks and strokes. The Pharmaceutical industry ridiculed his solution and tried to discredit his work, claiming that he had become crazy in his old age.
Personally I have much more faith in Dr. Pauling than I do in just about any other person that ever lived, except perhaps Fred Rogers. I follow Dr. Pauling's solution and I have for almost 20 years.
https://paulingblog.wordpress.com/2017/02/15/the-unified-the...