How an outsider bucked prevailing Alzheimer's theory, clawed for validation
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Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#2This seems to be referencing the path to mainstream exposure for the infectious theory of Alzheimer's. Prior discussions (not the same link) on HN, posted for reference because they touch on the past research that was previously posted here:
https://news.ycombinator.com/item?id=18306381 (this one's a comment I made associating the cortisol/Alz risk to the microbial Alz connection; it's nothing more than a hypothesis)
https://news.ycombinator.com/item?id=17446016
https://news.ycombinator.com/item?id=17540512
https://news.ycombinator.com/item?id=17540094 (this is the parent link for the antiviral risk reduction study -- a good read, comments and source article)
There's a decent amount of reading when scholar-googling:
https://scholar.google.com/scholar?q=hsv1+alzheimers
Moir's paper specifically: the relationship between β-Amyloid and viruses in the brain:
https://www.cell.com/neuron/fulltext/S0896-6273(18)30526-9 (study link)
There's also research pointing to sleep's function as helping clear out plaques such as beta-amyloid.
https://news.ycombinator.com/item?id=16026655
Finally, there's at least a bit of research pointing to boosted susceptibility of herpes viral infections when carrying ApoE4:
https://scholar.google.com/scholar?q=hsv1+apoe4
The novel conclusion from all of this, which I suspect is being actively investigated, is that there's a potentially complicated interplay of an enhanced viral infection (HSV/HHV enabled by ApoE4) + evolutionary defense going into overdrive (β-Amyloid) + (potentially) sleep deprivation keeping the body from clearing out the residue -> disease.
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I'm particularly motivated to track this research because of its prevalence in my family background and because, from what I can tell, I've thus far managed to avoid the environmental trigger-pull. I can already tell you I'll probably go on (val)acyclovir lifetime if I'm ever diagnosed with any particular strain, as it looks like active infection, with outbreaks, is what's likely to act as the first domino to tip.
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#3> Complaints about being denied NIH funding are as common among biomedical researchers as spilled test tubes after a Saturday night lab kegger
Is this supposed to mean complaints are common?
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#4This seems to be referencing the path to mainstream exposure for the infectious theory of Alzheimer's. Prior discussions (not the same link) on HN, posted for reference because they touch on the past research that was previously posted here: https://news.ycombinator.com/item?id=18306381 (this one's a comment I made associating the cortisol/Alz risk to the microbial Alz connection; it's nothing more than a hypothesis)…
From a previous discussion, beta-ameloyd isn't well studied, but it appears to be a viral catch-all, attaching to many viruses. The reason herpes is so significant is because it uses time-release capsules to continually reinfect a host user, and continually caught in the beta-ameloid. So herpes sufferers have more beta-ameloid to clear away most nights.
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#5> Complaints about being denied NIH funding are as common among biomedical researchers as spilled test tubes after a Saturday night lab kegger Is this supposed to mean complaints are common?
The article is littered with references to beer. As though the target demographic alcoholics who enjoy PopSci.
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#6> Complaints about being denied NIH funding are as common among biomedical researchers as spilled test tubes after a Saturday night lab kegger Is this supposed to mean complaints are common?
Yes. It's not particularly surprising, though, since research grants is basically a field with much higher demand than supply.
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#7One of things I like about the Howard Hughes Medical Institute (HHMI) is that they find great scientists and just fund them. The scientists can research whatever they want as long as they keep producing. I always wondered if a hybrid approach to funding would work well at the government level. The current, permission-based process would remain in place for new researchers to prove themselves, and then an HHMI-style process for researchers who have proven themselves. There would be checks in place and if the funded researchers stop performing then they have to go back to the normal process. There are several details that would have to be worked out to guard against politics, etc. I think this may overcome the government agencies tendency to reject truly new ideas especially when they contradict the prevailing theory.
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#8[deleted]
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#9> Complaints about being denied NIH funding are as common among biomedical researchers as spilled test tubes after a Saturday night lab kegger Is this supposed to mean complaints are common?
The article is littered with references to beer. As though the target demographic alcoholics who enjoy PopSci.
[deleted]
Re: How an outsider bucked prevailing Alzheimer's theory, clawed for validation
#10This all makes sense. APOE literally carries viruses around the body : https://bit.ly/2oRVFSr