Ibuprofen alters human testicular physiology including testosterone production
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Re: Ibuprofen alters human testicular physiology including testosterone production
#2I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor.
Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal because Tylenol has been pushed aside for the last 20 years as being more unsafe for children than Ibuprofen.
Re: Ibuprofen alters human testicular physiology including testosterone production
#3While the results do matter, this is probably being blown out of proportion
> One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk
Yeah, that's a lot of Ibuprofen for a long time
Re: Ibuprofen alters human testicular physiology including testosterone production
#4I read the paper, I saw the plots accompanying the paper, and I tried following the rabbit hole in search of some raw data that I can get my hands on, just to see if I can.
Perhaps the data is the result of the experiments that have been paid for by a third party, fine, but please mention that! People might be willing to pay for it, for example, me!
What's wrong with "Here's the raw data, here's how we measured it, Here's how we've shown the data, and look you can see for yourself that we are right! oh and the data costs $$$ much." ?
I understand experiment reproducibility is not incentivised in academia, but then why make it hard for an external party to reproduce it/study it?
Do we have to go through the usual "Contact the academic, maybe they answer, and maybe you'll get the same (version of) data that they used in that experiment, maybe you'll have to go through Elsevier, oh and you must have .edu/.ac.uk address to be taken seriously through all those requests."
What a chore. Just adds to the hate towards 'experts' and their opinions.
Re: Ibuprofen alters human testicular physiology including testosterone production
#5This was discussed ~3 weeks ago. Here's the thread--
https://news.ycombinator.com/item?id=16101072
Re: Ibuprofen alters human testicular physiology including testosterone production
#6While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
Have you seen how some people gobble this stuff?
I've felt compelled to say to more than one person: probably shouldn't take that much ...
Re: Ibuprofen alters human testicular physiology including testosterone production
#7I read the paper, I saw the plots accompanying the paper, and I tried following the rabbit hole in search of some raw data that I can get my hands on, just to see if I can. Perhaps the data is the result of the experiments that have been paid for by a third party, fine, but please mention that! People might be willing to pay for it, for example, me! What's wrong with "Here's the raw data, here's how we measured it, H…
Blame the journal.
Scientists are generally pretty busy. Writing a (life sciences) paper is an incredible amount of work usually done in a short period of time. Preparing raw data and explaining what everything means is quite involved. If they don't have to do something they won't.
The journal should mandate data access, then it will get done. This is crucial for human experiments, if only because the authors can lose the data and it will be gone forever.
Re: Ibuprofen alters human testicular physiology including testosterone production
#8I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
At least in Italy, children are almost exclusively given paracetamol (Tylenol) to lower temperature. Ibuprofen is only used as an anti-inflammatory drug, for example if they have faryngitis
Re: Ibuprofen alters human testicular physiology including testosterone production
#9While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
I've known plenty of people who do 400mg 2-3x/day for weeks/months.
Re: Ibuprofen alters human testicular physiology including testosterone production
#10I read the paper, I saw the plots accompanying the paper, and I tried following the rabbit hole in search of some raw data that I can get my hands on, just to see if I can. Perhaps the data is the result of the experiments that have been paid for by a third party, fine, but please mention that! People might be willing to pay for it, for example, me! What's wrong with "Here's the raw data, here's how we measured it, H…
Blame the journal. Scientists are generally pretty busy. Writing a (life sciences) paper is an incredible amount of work usually done in a short period of time. Preparing raw data and explaining what everything means is quite involved. If they don't have to do something they won't. The journal should mandate data access, then it will get done. This is crucial for human experiments, if only because the authors can los…
As far as I know this is slowly changing. According to scientists I've met (life science fields) there is an ongoing trend towards demanding raw data and even the code used to analyze it. Not every journal everywhere yet of course, but the consensus seemed to be that in 5 to 10 years it would become the new norm. Which might cause quite the disruption. Having seen quite the amounts of code written by PHD students I'm 100% sure tere are many, many bugs out there. Possibly leading to faulty results.