CRISPR eliminates HIV-1 infection in live animals
sciencedirect.com
CRISPR eliminates HIV-1 infection in live animals
1–10 of 267 posts
Re: CRISPR eliminates HIV-1 infection in live animals
#2Gene therapy (and CRISPR) is ultimately going to eliminate most if not every ailment/issue/genetic problem that we have, including aging and eye problems. Very thankful we are reaching the point where we can go into our cells and fix ourselves.
Re: CRISPR eliminates HIV-1 infection in live animals
#3CRISPR mediated genome editing does, CRISPR itself is not a magic HIV drug. That should probably be in the editorialized title.
Re: CRISPR eliminates HIV-1 infection in live animals
#4As exciting as this is, we already know how people have used the decreased danger of HIV infection to become careless about other types of STIs. Given that our antibiotics are losing their ability to treat many common STIs, an HIV cure without some advancement in antibiotics will be swapping one epidemic for a series of others.
Edit: I wanted to add a couple sources for my claims above. Once people stopped believing raw sex was an existential threat they started going nuts, falsely believing that everything else can just be cleared up with a pill. Let me also say that my SO worked on the front lines of public health for almost a decade so I might have a unique perspective on this issue because of what she experienced as part of her job.
http://www.cnn.com/2017/03/01/health/syphilis-newborns-partn...
http://www.huffingtonpost.com/entry/std-rates-in-the-us-rise...
http://www.ocregister.com/2017/01/26/syphilis-up-412-gonorrh...
Re: CRISPR eliminates HIV-1 infection in live animals
#5CRISPR mediated genome editing does, CRISPR itself is not a magic HIV drug. That should probably be in the editorialized title.
If one is familiar with the term 'CRISPR' in the first place, then the intended meaning is pretty clear.
Re: CRISPR eliminates HIV-1 infection in live animals
#6Gene therapy (and CRISPR) is ultimately going to eliminate most if not every ailment/issue/genetic problem that we have, including aging and eye problems. Very thankful we are reaching the point where we can go into our cells and fix ourselves.
That was the plan from the start, no? I was pretty disappointed to learn that most drug research is essentially mass testing all kinds of molecular agents that happen to show some beneficial effect for a problem at hand. It seems just too simple a method.
Re: CRISPR eliminates HIV-1 infection in live animals
#7Last time I read about CRISPR used to remove HIV from infected cells, the virus mutated to defeat the CRISPR attack - could this happen here?
Re: CRISPR eliminates HIV-1 infection in live animals
#8As exciting as this is, we already know how people have used the decreased danger of HIV infection to become careless about other types of STIs. Given that our antibiotics are losing their ability to treat many common STIs, an HIV cure without some advancement in antibiotics will be swapping one epidemic for a series of others. Edit: I wanted to add a couple sources for my claims above. Once people stopped believing…
Only if we fail to educate people about the dangers of other STIs.
Re: CRISPR eliminates HIV-1 infection in live animals
#9Wow, I had not connected the idea of using CRISPR genome editing with targeting virus dna segments. If I understand the technique correctly (and I am not a biologist for sure!) they used an adeno virus modified with a specific Cas9 setup to elide HIV DNA from cells it infected (normally I associate viruses with adding DNA rather than removing it :-)
Is that even close to a correct interpretation? It sounds like the technique could be used for pretty much any virus dna you wanted to target.
Re: CRISPR eliminates HIV-1 infection in live animals
#10It's awesome that this is possible. Right now HIV infections are basically a minor nuisance, provided you're taking the appropriate medication, but this bodes well for future treatment of viral infections.