A theory on how insulin resistance, metabolic disease begin
medicalxpress.com
A theory on how insulin resistance, metabolic disease begin
1–10 of 56 posts
Re: A theory on how insulin resistance, metabolic disease begin
#2The only misleading word here is "new."
Edit: Thanks admins for fixing.
Re: A theory on how insulin resistance, metabolic disease begin
#3The only misleading word here is "new." Edit: Thanks admins for fixing.
I haven't heard of ChREBP before. Is it something that has been well known in the research community for awhile? Has there been consensus as to its role in the disease pathway, or is it recent?
(I took two semesters of immunology in my biochem undergrad--courses that I would have expected to cover this. I was never exposed to literature or material on this protein. I also haven't heard of it in the primary literature I do occasionally still read.)
Re: A theory on how insulin resistance, metabolic disease begin
#4tl; dr: A mouse study (corroborated by in vitro experiments with human liver tissue) found that a liver signaling protein, ChREBP, is activated by fructose consumption and causes the liver to produce glucose in a way that isn't shut down by high insulin levels. IMO this is not so much a "new theory" as an insight into the behavior of a particular pathway that would be part of a theory.
Re: A theory on how insulin resistance, metabolic disease begin
#5My retired, at the time, 71 year old doctor was thrown out of a medical conference. (Don't know if he was literally thrown out, but that's what he told me. Maybe for dramatic effect?
Why? He stood up, and said there's no such thing as Metabolic disease. He said they(my patients) are just inactive, and out of shape, and eat the wrong foods.
He told me this at point in my life when I was drinking to excess, and not exercising. (I was drinking because I had a anxiety disorder that didn't respond to anything other than alcohol. It came on in graduate school. It came on after a series of bad anxiety attacks. The anxiety was unrelenting.)
My point is when I cut back on my alcohol intake, lost a few pounds, and got back to exercising; I didn't have Metabolic syndrome anymore.
(I haven't followed metabolic disease. There might be something to it than being out of shape, and drinking/eating too much? I don't know. I just know Dr. Shepard was the last good doctor I had. Last doctor who actually listened to my heart murmur. The last Doctor who palpated patients for obvious tumors. The last Doctor who appeared to care. A Doctor of a different generation?)
Re: A theory on how insulin resistance, metabolic disease begin
#6The only misleading word here is "new." Edit: Thanks admins for fixing.
I haven't heard of ChREBP before. Is it something that has been well known in the research community for awhile? Has there been consensus as to its role in the disease pathway, or is it recent? (I took two semesters of immunology in my biochem undergrad--courses that I would have expected to cover this. I was never exposed to literature or material on this protein. I also haven't heard of it in the primary literature…
The most major finding, which appears to be this:
> The study found that fructose initiates a process that causes the liver to keep making glucose and raising blood glucose levels, even as insulin tries to keep glucose production in check.
Is not ground-breaking. It's how the liver metabolizes fructose. The liver can't respond to insulin because it needs to metabolize the fructose.
Re: A theory on how insulin resistance, metabolic disease begin
#7The connection to the consumption of animal products to diabetes is rarely the focus but we know there is a big connection. Consider Kempner's Rice Diet which used sugar to successfully treat diabetes! So I doubt sugar is a sufficient condition. This is politics not science.
Re: A theory on how insulin resistance, metabolic disease begin
#8The connection to the consumption of animal products to diabetes is rarely the focus but we know there is a big connection. Consider Kempner's Rice Diet which used sugar to successfully treat diabetes! So I doubt sugar is a sufficient condition. This is politics not science.
I've never heard of a connection between consuming animal products and diabetes. Perhaps you can expand on this.
Re: A theory on how insulin resistance, metabolic disease begin
#9The connection to the consumption of animal products to diabetes is rarely the focus but we know there is a big connection. Consider Kempner's Rice Diet which used sugar to successfully treat diabetes! So I doubt sugar is a sufficient condition. This is politics not science.
What!?
Do you have a background in biochemistry, medicinal chemistry, or a related field, or perhaps some evidence to back this up? Forgive my skepticism, but this is so far off topic and, frankly, sounds like a homeopathy / "conspiracy theory" subject.
Diabetes is a complex disease, but I don't think you underplay the preponderance of evidence implicating the role of sugar. (It is, after all, one of the principle elements of the insulin pathway.)
Re: A theory on how insulin resistance, metabolic disease begin
#10I think this is the most interesting point:
>The new findings suggest fatty liver disease may be a red herring, Herman said. The likely cause of insulin resistance may not be the buildup of fat in the liver, as commonly believed, but rather the processes activated by ChREBP, which may then contribute to the development of both fatty liver and increased glucose production.