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Covid vaccine: First ‘milestone’ vaccine offers 90% protection

bbc.co.uk

941–950 of 1001 posts

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#941

The Pfizer press release says they 57% the way to statistical desired significance. They want the 164 of the placebos to catch covid, and 94 have done so far.

I thought it was 94 total not just the placebos. if it’s 90% effective 8 or 9 people who got the vaccine would catch it. Unless there’s some more statistics to the 90% figure

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#942
post #441

Earlier quoted context omitted.

It will still take a long time before a sufficient number of people have been vaccinated that life can return back to normal.

One of the lead doctors in the UK is saying life will start to look normal in Spring 2021 (albeit, I assume he was referring to the UK alone). There's good reason for cautious optimism & patience. Science has done its job; now we need to push for coordination between infrastructure, government, and business to finish it.

I guess it depends on what they mean by "start". Lead doctors in Germany say that it'll probably take until 2022 to vaccinate most people.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#943

Given we can't even get people to wear masks, regardless of efficacy I think we mainly have an education issue and half the country voted for "fuck that let's die." I think we need to spend as much time/money on a social campaign with mask mandates, social distancing, quarantine, contact tracing.

I think one of the reasons people won't wear masks is because they're mandated. Many are worried in the short-term about the spread of COVID-19, but after we come out of it the government has more power. I think it's important to understand and respect that other people have different priorities. In this case, the US was born out of fighting tyranny and that is a bigger concern to some because a tyrannical government…

It's just a mask. The "power" the government is applying to "coerce" you into wearing a mask must be weighed against the burden being imposed (extremely low, less than asking you to at least wear underwear in public/near schools) and the benefits (extremely high, masks work).

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#944

Earlier quoted context omitted.

I think we can eradicate it by contact tracing. With 90% efficiency it will be extremely tough for the virus to spread. For any new cases you simply test everyone in the vicinity of the infected person. But I don't think even that will be necessary. 90% efficiency reduces R so much, it will probably die out on its own. The real problem is mutations that are not covered by the vaccine. If it mutates as efficiently as…

> 90% efficiency reduces R so much You’re assuming 100pct of the population takes the vaccine. I’d be surprised if it’s more than 50% the first year

Can only make 1.5b doses in 2021, and 2 does/individual required, which is 750m individuals out of a world population of 7.8b.

Less than 10% can get it I the first year.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#945
post #842
post #783

Earlier quoted context omitted.

You're high if you think science has nothing to do with politics.

to add onto this, one of my entire classes at NYU "Covid and economic policy" we've literally just looked at science and how its effected the political and economic landscape. Yet, you say stuff like what you did here on hacker news and you get reported / flagged / greyed out. That is why I dont contribute here anymore, it's basically like reddit-lite

Yes. The most frustrating topic for me is to bring up is the evidence that dis-agrees with the man-made climate change hypothesis. Source, Weathermans Guide to the Sun by Ben Davidson. But I cant even get my long time friends to explore that evidence, let alone anyone on internet forums.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#946

Earlier quoted context omitted.

Why, biologically speaking, does it need to be that cold? I'm guessing something breaks down at higher temperatures? (That's -112 F, for anyone else wondering.)

It’s an RNA vaccine. RNA degrades at room temperature.

Yes, but why that low?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#947
post #619

you can be sure that even with the vaccine that I'm going to be wearing my mask around everywhere for a long time

I'm not sure that's really needed, but if you want to I'd suggest getting something you can clean, like a silicone surgical respirator, as a cloth or paper mask would get pretty nasty after a while.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#948

Earlier quoted context omitted.

> What are the markets, a handful of rich in banks and large corporations? Glad you asked. No, "the markets" are not simply a handful of rich people, banks and large corporations. The markets are also more than just "stocks." In fact, the majority of "the markets" is actually bonds, and most of those bonds are debt issued by nearly all the countries of the world (sovereign bonds). I think roughly 80 Trillion dollars,…

>If you live in a country with roads, infrastructure, buildings, etc.--then the markets are responsible for everything around you. See, this kind of thing really gets to me. Here's you circa 1290: "If you live in a fiefdom with wells, irrigation, castles, etc. -- then your Lord is responsible for everything around you." See how fallacious that sounds when you transpose it this way? The central issue is that you're ju…

> "your Lord is responsible for everything around you." See how fallacious that sounds...?"

Of course it sounds fallacious--you've constructed a straw man out of my original argument.

There's nothing circular about the concept of debt. It's a fundamental aspect of how our economy works. The way debt is raised is through markets. Again, this is not a controversial or political statement.

Of course workers built the roads. And they were paid to build those roads by debt raised via bond markets. Governments and organizations use debt to bring the future into the present and amortize large investments over long periods of time. The liquidity and demand for this debt in the global markets allows them to do this.

No marketplace for debt = no way to reliably execute big infrastructure projects for all but the richest of countries. The market (the demand for debt) is literally the enabler.

Nothing I've said here is a mischaracterization of reality.

> It's a pretty shitty indicator, I'd say.

Again, I'm not advocating that short term financial market gyrations have any explanatory power for the future. I'm simply explaining why journalists use it: because it's easy.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#949

Earlier quoted context omitted.

> My DNA will be permanently altered and permanently create fake covid proteins ? No, in fact, mechanisms in cells are in places so that "heteroduplexes" (meaning one filament of RNA and one of DNA paired together) are quickly degraded. Secondly, the RNA doesn't even need to get to the nucleus, where the DNA is. All it needs is to land in the cytoplasm, where it will get processed by the protein synthesis machinery (…

That is all true as long as the RNA doesn’t replicate itself and only produces antigens. However, I couldn’t find any papers at all that discussed if any of the current mRNA vaccine candidates self replicate their RNA to amplify the antigen production. I’d love some good references that address that.

This doesn't replicate, AFAICS. The one in Phase I by Imperial College is instead self-replicating.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#950

Earlier quoted context omitted.

It means that it includes people from different ethnicity, ages (also younger and older people) and some immunocompromised people.

shouldnt they be focusing on older people? in fact if they are first to be vaccinated the fatality would drop very very significantly

The 56-85 age bracket is 45% of the volounteers tested, according to Pfizer.
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