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‘Breakthrough’ obesity drugs that have stunned researchers

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#931

Earlier quoted context omitted.

I think it makes sense to someone who has never tried to starve their body. Doing that will change your appreciation for the human brain.

I'm not saying it's easy. I'm saying the reason people don't do it is because they don't have the willpower. Yes, it is possible to choose to starve yourself, just requires a ton of willpower.

Starving yourself often slows down ur metabolism even more, which makes it harder to lose weight without medical issues. the will power to put urself into coma Jesus Christ.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#932

I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…

First off, no, not everyone should be on these drugs, there are side effects as well as known drug interactions that can be dangerous and not everyone needs them.

Second, please, please, please stop listing your BMI as if it were a definitive measure of health. To begin with it doesn't correlate well with actual percentage body fat because it doesn't differentiate between fat and muscle. Second, the study which created the BMI was based on a population sample from a single town and all participants were within 4 inches of each other in height, and nearly all were effectively average height with similar lean body masses. If your lean body mass does not conform to the expected range from that study, BMI cannot accurately determine if you are obese, skinny, a body builder or just tall/short.

Finally, rapid weightloss is dangerous, and if you're eating fewer than 1k calories in a day while experiencing extreme fatigue and brain fog, you are more likely to be losing significant muscle mass than fat. This is may be extremely because your heart could be weakened, which could kill you. It's great that your cholesterol and overall weight is down, it's terrifying that you're eating so few calories while being unable to maintain enough physical activity to keep your body from canabilizing vital muscle tissues.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#933
post #895

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>What people who aren't fat do is intellectually recognize that "I could eat forever" feeling, and don't fall for it. That's where the willpower comes into play. This isn't how it is for me. Of course I've had the "I could eat forever, so let's not" thoughts before, but only in certain contexts like if I'm at a buffet dinner. Ordinarily I just get full and then stop. No mental pep-talk needed. I've noticed in these d…

Willpower absolutely has a scientific definition, I’m on mobile but there have been hundreds of studies done on willpower and each and every one of them must define the term before studying it.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#934

Earlier quoted context omitted.

> The thing is, I'm never full. I can eat until I physically can't eat anymore (not something I do regularly, of course), and as soon as my stomach has emptied a bit, I feel fairly hungry again. "Eat until you feel full" is literally a human experience I had never really had. I feel exactly the way you do, and yes, I was fat, lost it in one go and never gained it back. I try to keep my BMI around 18, never went over…

> Not that hard to stop yourself from going to the store again or ordering more Well, actually... I'm fat. Like BMI 40 fat. Most of my life I have been fat. I was laughed at in school for it, as far back as I can remember. It probably wasn't all that bad when I think back. Certainly not as bad as now. But I was the fat kid in class, and I felt like the fat kid. Anyway, I have lost a lot of it at a few points. Once by…

If you're content with where you are then that's fine. I won't claim it's going to be easy to change things. But I do think there are few things you could change that will nearly guarantee success:

- There's no good or bad food. The number is the only thing that matters. Don't feel bad about eating chips and candy everyday. That's pretty much what I do. All you need is to hit the number.

- Always keep track of how much you've eaten. A big binge is not an excuse to stop counting. After a year or so, counting will become second nature and can be done purely with mental math. But initially, you want to write all the numbers down. Date | calories in | morning weight.

- Don't tie the counting efforts to any other effort. You mention walking 5 hours a day. That's some other unrelated thing. Don't ever mentally link this to your weight loss effort. If you want to do it, do it, but it should have nothing to do with losing weight. Counting and keeping records is your primary job.

- Your family should know what you're up to. They're there to help you achieve your goals. If you've already eaten, they shouldn't let you have a family meal with them. If they just let you get away with this, let them know you don't appreciate it. When you mess up, they should care and think it's a bad thing.

- Get this idea of a "cycle" out of your head. There is no cycle, every day is a new day. Your behavior only looks like some cycle caused by external forces post facto. Everybody trying to form a habit has a similar experience. There is nothing weight loss specific going on here. When you break a good streak everything can go out of the window. This is why it's important to keep the required actions as simple as possible. The more you couple different efforts the harder it's going to be. When you mess up you have to take the loss and move on. A good streak helps but don't dwell on breaking it.

- You have to have a sense of urgency and importance. Those around you should too. "I guess that means I'll get some obesity disease at some point" - just think how ridiculous that sounds. You know you can potentially prevent a serious disease (most people never have that opportunity) but you're just gonna sit there and let some cycle run its course. I mean, come on! How can you wake up everyday and not want to stop it today? What about your children? Perhaps they will inherit your eating habits (stats do show high heritablity), perhaps it would be nice to show them how to keep it under control? You owe it to them. Why doesn't your spouse think that's a huge deal?

It's one of the few things in life where you are literally guaranteed to get a good result if you do what you're supposed to do. There's a lot of advice on how to do this or that, get rich or whatever. But you can never prove these things are guaranteed to work so I can understand if people have a hard time motivating themselves. With weight loss you have a 100% guarantee of success. Personally, I don't see it as some random little problem. Pretty much any effort in life looks like this. You want an outcome, you think of the necessary actions and then the entire ballgame is about actually implementing these actions.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#935

This is good news (probably?), but wanted to chime in with a tangent. Also going to preface this by saying I have struggled with weight my entire life and have lost and gained substantial weight through diet alone, always gaining it back and then some — but I think I found something that has worked for me and I have been reflecting on what I wish I was told a long time ago. It's not necessarily a problem to be "obese…

This is really interesting. The idea of intentionally putting on weight terrifies me because I worked so hard in college to lose weight. What does your plan look like long-term? Are you just going to keep gaining muscle and working out for the rest of your life, or do you plan to stop? Obviously your TDEE is going to go up with more muscle. I wonder if there's a stable point where you can eat a 'normal' (read: not pr…

For the first 6 months I basically didn't worry too much about diet, except getting more protein and working extremely hard on my two workouts (which has since expanded to 3 workouts a week).

What happened was I put on a ton of muscle, and actually lost some weight... in the end I was 12lbs lighter, which doesn't seem like a lot but with the amount of muscle is EXTREMELY noticeable.

For me, seeing my body get more stronger and more muscular was a revelation, it's really fun to see the growth in those areas, much more than suffering to get "skinny fat". So now I'm actually working 4-6 week stints of weight loss into my program where I target 2lbs of fat loss week, while keeping the training intensity high (with lower volume to combat fatigue) to maintain the muscle I have built. I'll follow that with 2-3 months of maybe a slight surplus in calories to build (which comes with some fat gain). A few cycles of that and I'll be golden :)

From a health span and longevity standpoint, having lean body muscle is absolutely crucial for aging, and it's something I plan to not stop doing, even if I fall off the nutrition wagon completely, I'll at least be increasing my bone density and muscle mass which will counteract a lot of whatever bad food habits I'm doing at the time.

The cool thing about muscle vs just pure weight loss, is that muscle isn't super hard to maintain once you have it. The amount of stimulus you need to keep the muscle, especially in an energy balance or surplus environment is surprisingly small it turns out. So to me it's much more rewarding than a crash diet that can be completely erased and then-some in a matter of months.

I wish I had this frame of mind a long time ago, it has personally helped me tremendously.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#936

Earlier quoted context omitted.

> to suggest that people have a natural weight and that's the cause of this seems absurd to me People do have a natural weight, and a fraction of people are genetically predisposed to be overweight regardless of lifestyle. But what I find impossible to accept is that somehow that number has mushroomed in the past half-century and particularly in the U.S. I've lived and/or worked on every continent over the past 40 ye…

I have also noticed myself and my partner gain weight when we live in the US. I'll make it a little more concerning: I mostly don't eat processed foods. I buy the raw ingredients and cook myself.

Do you often cook with ingredients like canned beans or canned diced tomatoes or premade stock? Do you buy any kind of grocery store bread, including the "fresh" stuff from the bakery section? All of these things usually contain added sugar in the US, sometimes in shockingly huge amounts. I think people from other countries don't know to look out for sugar in these kinds of processed but not ultra-processed food items because such things don't usually contain sugar (because it's totally unnecessary). So even if you're mostly cooking with raw ingredients you could be getting way more sugar in your diet than you did wherever you lived before.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#937

Earlier quoted context omitted.

I did a little bit of research and for people in the UK it appears to be substantially less. I found a few health companies offering it for <$250/mo. I’ll probably wait until it’s readily available on the NHS but it is tempting.

My US doctor recommended it to me last week and said there was a way for it to cost about $200/mo if I want to do that. I thought it was strange that he said it that way instead of just saying the price, but I didn't follow up because we were 45 minutes into the appointment and I was ready to get out of there. I'm supposed to book a follow up appointment after I've read about it, so I guess I'll find out what he mean…

14mg Rybelsus can be had for about $200/mo through Canadian pharmacies.

Look at 1800rxonline.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#938
post #574

Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…

N of 1, but I've gone off it for months and maintained my weight.

How much did you lose, how long did you take it, and how long have you been off of it?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#940

Earlier quoted context omitted.

I have also noticed myself and my partner gain weight when we live in the US. I'll make it a little more concerning: I mostly don't eat processed foods. I buy the raw ingredients and cook myself.

Do you often cook with ingredients like canned beans or canned diced tomatoes or premade stock? Do you buy any kind of grocery store bread, including the "fresh" stuff from the bakery section? All of these things usually contain added sugar in the US, sometimes in shockingly huge amounts. I think people from other countries don't know to look out for sugar in these kinds of processed but not ultra-processed food item…

Nope. I never buy anything without reading ingredients and yes the US is really bad about adding sugar to stuff. Even some meat which is absurd.

But when I say I cook from scratch I mean it. If I want beans I buy a bag of dried beans. I will sometimes buy canned Marzano tomatoes from Italy, ingredients: tomatoes.

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