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Sleep research led to a new sleep apnea drug

temertymedicine.utoronto.ca

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Re: Sleep research led to a new sleep apnea drug

#91

Post by EdwardDiego »

Insanity wrote: post #28
EdwardDiego wrote: post #3

I don't have sleep apnea, as in, my severe snoring doesn't cause significant drops in blood oxygen levels, but it's still severely impacted my life - when my wife and I married, I spent the first night of our honeymoon awake so that she could sleep. Oh and it's so loud that I'm at risk of damaging my own hearing. And I bounced off CPAP hard, no matter what I tried, I would eventually remove the mask in my sleep, it w…

You snor so loud it damages your own hearing? Can you wear ear plugs to sleep?

Not yet it hasn't, but another 10 years of exposure to it will - and I do. :)

I phrased it like that to try to convey the impact my snoring has on anyone near me.

When I got hunting or tramping, and intend to stay at a backcountry hut, I always carry my bivvy bag in case there's other people staying at the hut, if there are, I go sleep in my bivvy bag about 50m away from the hut.

Nothing like waking up and 20 other people all want to beat you.

Re: Sleep research led to a new sleep apnea drug

#92

Post by EdwardDiego »

swe123456 wrote: post #90
EdwardDiego wrote: post #3

I don't have sleep apnea, as in, my severe snoring doesn't cause significant drops in blood oxygen levels, but it's still severely impacted my life - when my wife and I married, I spent the first night of our honeymoon awake so that she could sleep. Oh and it's so loud that I'm at risk of damaging my own hearing. And I bounced off CPAP hard, no matter what I tried, I would eventually remove the mask in my sleep, it w…

I found a way to stop removing the mask through smarthome magic: flash my lights if I take off the mask. Parts: 1. Smarthome coordinator - HomeAssistant/AppDaemon (runs on my desktop) 2. Prescense sensor - e.g. Aqara FP2 3. Smart light - e.g. Phillips Hue 4. Smart Plug/Power Meter - e.g. Kasa ESP25P4 5. Claude Code to write the logic ..... The alarm goes off if all of the following are true: 1. it's in sleep period (…

I think I, ironically, sleep to deeply fir that to work for me, but it's not a bad idea at all!

Re: Sleep research led to a new sleep apnea drug

#94

Post by swe123456 »

EdwardDiego wrote: post #92
swe123456 wrote: post #90

Earlier quoted context omitted.

I found a way to stop removing the mask through smarthome magic: flash my lights if I take off the mask. Parts: 1. Smarthome coordinator - HomeAssistant/AppDaemon (runs on my desktop) 2. Prescense sensor - e.g. Aqara FP2 3. Smart light - e.g. Phillips Hue 4. Smart Plug/Power Meter - e.g. Kasa ESP25P4 5. Claude Code to write the logic ..... The alarm goes off if all of the following are true: 1. it's in sleep period (…

I think I, ironically, sleep to deeply fir that to work for me, but it's not a bad idea at all!

Then swap out the Phillips Hue for super bright corncob LEDs, or an air siren, or a bed shaker

Re: Sleep research led to a new sleep apnea drug

#95

Post by thfuran »

dnnddidiej wrote: post #77
calvinmorrison wrote: post #38

Earlier quoted context omitted.

#1 symptom - fat necks! if you are like me and had a 17" neck at 185 in high school and now boast a 18.5".... you have it!

Why is that?

Sleep apnea can indirectly cause weight gain, but obesity—particularly excess fat on the neck—is the main controllable risk factor for obstructive sleep apnea, so it’s primarily the other way around.

Re: Sleep research led to a new sleep apnea drug

#96

Post by aaron695 »

Aurornis wrote: post #61
gpt5 wrote: post #2

People should be more aware of the symptoms of sleep apneas - the lack of energy during the day, feeling tired, waking up throughout the night, waking up tired/exhausted, etc. People with untreated sleep apnea have multiple folds higher chances to be depressed, unemployed, and have trouble with basic life functions, in addition to the long term health consequences of depriving your brain from Oxygen. I've suggested 4…

This is worth pursuing for anyone with the symptoms. However please do it with a reputable doctor, preferably associated with an established institution. Watch out for some of the specialty clinics and independent practice doctors who treat apnea like a cash cow. Sleep study scoring is theoretically set by strict rules, but in practice there can be differences between operators and clinics. Some clinics use this to t…

[dead]

Re: Sleep research led to a new sleep apnea drug

#97

Post by tedk-42 »

procone wrote: post #74
tedk-42 wrote: post #60

Earlier quoted context omitted.

Do you run regularly? Overweight by chance? I've put on a bit of weight sunce having kids and my breathing at night is much worse than before.

You have no idea what you're talking about and it shows by what you choose to type. It's not exclusively caused by fitness or lack thereof. A cursory Google search would show you this. It's not "breathing at night", it's literally suffocating in your sleep. This place used to be full of intellectuals. It's a real shame.

Wow you sound very defensive.

If it's not obvious I meant breathing while sleeping at night in a sleep apnea discussion, I think you need to analyse your own internal bias and possible self-hate.

I'm very sure i have sleep apnea now as i wake up literally in panic where i'm not breathing + have a full bladder and need to go a few times a night (which i've read as a kidney response with sleep apnea).

As i said this all came about with extra weight gain in the past few months.

Re: Sleep research led to a new sleep apnea drug

#98

Post by petercooper »

There are some older studies that showed nicotine (not via smoking, which makes sleep apnea worse) had a positive effect on sleep apnea as well due to the stimulation increasing muscular activity in the airways. Obviously lots of downsides too so it never caught on, but this seems to have a similar mechanism.

Re: Sleep research led to a new sleep apnea drug

#100

Post by sonink »

patrickdavey wrote: post #23
gpt5 wrote: post #2

People should be more aware of the symptoms of sleep apneas - the lack of energy during the day, feeling tired, waking up throughout the night, waking up tired/exhausted, etc. People with untreated sleep apnea have multiple folds higher chances to be depressed, unemployed, and have trouble with basic life functions, in addition to the long term health consequences of depriving your brain from Oxygen. I've suggested 4…

I've tried a CPAP machine for 6 weeks and felt no different and gave up. I think I was a 6 on the scale. I wish it had worked though! Currently I've just given up and embracing feeling relatively tired all the time. I've tried side sleeping devices (woody knows backpack) mandibular advancement splints etc. So hard to tell (I find anyway) to get to a definitive answer

You should consider getting an Wellue O2 ring. This is something you can use to monitor your oxygen saturation throughout the night. Use it with the CPAP and also otherwise. If your oxygen saturation is better with CPAP - you know that it is working. You will eventually feel better.

The main thing about CPAP is that, and imo almost everyone gets wrong, is that you need to titrate it. CPAP is sold as an Automatic Pressure device, but in practice it doesnt work like that. You almost always need to set it just 1 number below and 1 above your required pressure - more like a fixed pressure device. And getting it working correctly - with all the mask combinations, leaking issues, pressure calliberation, supporting gear like mouth tapes and neck bands - can take months. It is incredibly hard - BUT - it is worth it. The best resource for me has been the reddit to get this right.

The key is to track your saturation everyday with all the small tweaks you make and the only way to do it is using something like the O2 ring.

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