I'm a fan of removing any dependencies on external libraries and writing my own solution from scratch, but there's a good reason why I decided not to do so with Tailwind: They offer an optimization for production that ensures that you never ship more than the bare minimum of CSS needed. This means you can keep your palette of color, spacing, and other options fully enumerated in `globals.css` and elsewhere, without worrying whether you're using all those variants in production. Moreover, if you're working within a framework, such as Next.js, this minimization step automatically happens when you build, without even having to worry about whether it's happening. This alone is a compelling reason, at least for me, not to migrate from Tailwind.
Also, I've never found any restrictions in Tailwind in using inline CSS that weren't readily navigable, or in implementing really nice responsive grids that handle different screen widths for instance using Tailwind's grid tooling. I definitely have solved each of the scenarios described in this article using Tailwind or a Tailwind-CSS combination, but it's true that they don't have grid-column-areas natively. Still, I haven't yet found that to be a significant restriction in getting responsive grid layouts.
I think the biggest issue with Tailwind is simply that it takes a long time to get used to reading it. We all learn that inline CSS is bad, globally scoped CSS is best, etc., and we get used to seeing clean simple HTML. Then we look at real-world code featuring Tailwind and it just looks so hard to read at first, especially because the lines are so long. I guess I just have been using it long enough that I've gotten completely used to the way it looks, but I do remember it took me a very long time to get comfortable with reading Tailwind. After a long while, I concluded that, for me, Tailwind really is more efficient and maintainable and even more readable, but it definitely took quite a bit.