Enhancing gut-brain communication reversed cognitive decline in aging mice

Post by WarmWash » Fri, Mar 13, 2026, 1:26 AM UTC

y-curious wrote: post #30

zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

What did you do for heartburn? Just looking for ideas. I noticed reducing gluten helped me personally a lot

Post by jb1991 » Fri, Mar 13, 2026, 1:40 AM UTC

Aurornis wrote: post #62

zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

> 1. I stopped drinking heavily and using other drugs, i.e. marijuana Heavy alcohol use and marijuana are both known to impact memory and recall directly. Discontinuing both of those explains changes in memory. Attributing this to microbiome changes does not follow.

Post by jb1991 » Fri, Mar 13, 2026, 1:46 AM UTC

reverius42 wrote: post #73

throwawaytwit9 wrote: post #59

Earlier quoted context omitted.

It may not work for you but I had years of chronic heartburn. While sick with covid in 2020, I stopped consuming coffee and alcohol. It took a few months and for the long covid symptoms to subside, and then no more heartburn. At all. I felt really dumb that I never connected it to coffee before. I didn’t experience direct symptoms from coffee and I didn’t consume an excess amount. But it definitely was the cause.

I'm a couple weeks into giving up coffee because of heartburn, and yeah, this tracks... unfortunately. I've replaced heartburn with heartache (having given up a beverage I've enjoyed daily for over 20 years).

Post by virtue3 » Fri, Mar 13, 2026, 2:02 AM UTC

WarmWash wrote: post #91

y-curious wrote: post #30

Earlier quoted context omitted.

What did you do for heartburn? Just looking for ideas. I noticed reducing gluten helped me personally a lot

I stopped taking esomeprazole after being on it for 4 years, and frequently had to supplement with famotidine and tums anyway. I had an infection and was prescribed antibiotics, and needed to pause the esomeprazole. I asked gemini about it and it suggested I take two probiotics while on the antibiotics, Saccharomyces boulardii and Lactobacillus rhamnosus GG. I noticed after a few days that I wasn't getting heartburn,…

Post by adaptbrian » Fri, Mar 13, 2026, 2:14 AM UTC

systemsweird wrote: post #88

slibhb wrote: post #46

Earlier quoted context omitted.

In my opinion, gut microbiome stuff is massively overhyped. Here's a study that tried fecal transplants to treat mental illness (and found no effect): https://pubmed.ncbi.nlm.nih.gov/41785480/ The pattern with this stuff is that, when a blinded study is carried out, there's usually no effect.

I think mainstream is mostly looking at the microbiome stuff wrong. Your microbiome is the downstream proxy of good lifestyle habits, not generally something to directly manage. Good diet, exercise, reducing stress, and sleeping well will improve digestion and all the downstream variables like microbiome, physical health, and mental health. This is basic ecology, the bacterial population dynamics in your colon are a…