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Drug trio found to block tumour resistance in pancreatic cancer in mouse models

drugtargetreview.com

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Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#91

Post by tw04 »

WJW wrote: post #86
post_break wrote: post #80

Earlier quoted context omitted.

If I had 6 months to live, and had no other options, I wouldn't care if a drug killed me in 10 days. Give me the option.

It's not just those two choices though. It could be "6 months in relative comfort" and "10 days begging each minute to die but you can't because you're borderline unconscious". Or anything in between. Just saying. Medical guidelines are there for a reason and are often, as they say in the military, "written in blood".

> "10 days begging each minute to die but you can't because you're borderline unconscious"

They aren’t going to know if it does that until they give it to a human in the first place. The only difference in giving it now is they lack a control group.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#92

Post by standeven »

wat10000 wrote: post #76
A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

We might take it too far, but the fear of quack medicine is extremely rational.

Every time I see homeopathic medicine on the shelves in a pharmacy, I think we’re not taking it far enough.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#93

Post by ineedaj0b »

dylan604 wrote: post #85
post_break wrote: post #80

Earlier quoted context omitted.

If I had 6 months to live, and had no other options, I wouldn't care if a drug killed me in 10 days. Give me the option.

bigPharma doesn't care about that. They care about the publicity of their drug killing someone faster than the cancer.

No. No no no.

Big Pharma needs good data. And they have annoying FDAs/whatever-regulations-body slowing them down.

If you have a serious disease they might not mind you taking it. But if you have a serious disease plus your kidneys have already shutdown - w/e drug won’t save you. The death counts as a negative. “Let me take it anyway” well fine but it’s not some huge conspiracy.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#94

Post by [deleted] »

A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

[deleted]

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#95

Post by shusaku »

quentindanjou wrote: post #90

As we are always starting with mice, I am wondering if there are some drug that could work on humans but not on mice.

Absolutely there is, which is why they haven’t genetically modify the mice for useful experiments.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#96

Post by yieldcrv »

A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

good news, are current FDA has many ways of fast tracking a treatment and a willingness to do so

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#97

Post by _zagj »

jjtheblunt wrote: post #68
tansey wrote: post #34

For all the folks complaining about "it's only in mice! things never work in humans!" -- I work at MSK and we definitely have seen success treating PDAC in humans: https://www.nature.com/articles/s41586-023-06063-y "Why don't I see these treatments hitting the general public?" Because trials like these are phase I/II. Then you need a phase III that takes a long time to recruit a large cohort and has overall survival…

What's MSK?

Memorial Sloan Kettering, one of the NCI(National Cancer Institute)-Designated Cancer Centers. If you're getting treated for cancer, the NCI-Designated Cancer Centers are usually your best bet.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#98

Post by A_D_E_P_T »

zen928 wrote: post #77
A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

IMO, if you view your question from the ethical framework of "do no harm" i.e. the hippocratic oath instead of "move fast and break things", I can clearly see reason for the apprehension. The standards aren't positioned to catch "quack medicine" but to require full understanding before asking someone else to put something in their bodies. It's somewhat of an entitled stance that youd be okay with other people possibl…

Consider what the oath actually says.

> I will not give poison to anyone though asked to do so, nor will I suggest such a plan. Similarly I will not give a pessary to a woman to cause abortion. But in purity and in holiness I will guard my life and my art.

Now consider that doctors in Canada and Europe are literally administering MAID as we speak. In other words, administering poison with intent to kill. Further, consider that doctors have participated in administering lethal injections, etc. I could go on all day.

But you'd invoke the Hippocratic Oath to deny people with fatal diseases access to potentially curative treatments, though admittedly experimental? That's a funny view of the oath you've got there, and either an uninformed or very funny take on medical ethics, as well.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#99

Post by dyauspitr »

A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

That’s because we have a system that financially punishes fraud and mismanagement which is what we want and should keep.

There should be a way for terminal cases to volunteer for early trials and I believe there is already legislation that provides that but it’s not used and funded enough.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#100

Post by fiddlerwoaroof »

snapcaster wrote: post #49
A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

Yeah putting myself in the shoes of someone with this disease or a loved one with this disease I would be so incredibly angry that we weren't allowed to try something when the alternative is certain death

I think you could mitigate some of the problems by making the drug company pay for the treatment before approval.
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