91–100 of 106 posts
The fact it spun of of research on Gila monsters is still crazy to me.
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What don't we understand about the obesity epidemic? The story seems pretty clear to me at this point: * Almost everyone has access to a wide variety of delicious food, which we on average enjoy eating more of than is required to maintain a healthy weight. * We don't want the government to forcibly restrict people's food access. * Research consistently shows that voluntary portion control works occasionally in the sh…
I would argue that your argument is simplistic and does not account for observed geographical variations. Japan does not have an obesity epidemic. The US has an extreme obesity epidemic. There does not seem to be any good genetical explanation, there might be cultural based behavioral explanations, but Japanese communities in the US are also more obese than ones in Japan (although less obese than the general US popul…
i think it’s due to the increasing prevalence of dairy
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> Given the general health benefits that are being observed with GLP1-s the only reason to get off them is costs imo There’s also the perverse incentives wrt broader society. Enabling the average person to control their physical health is orders of magnitude better for society and orders of magnitude less profitable than the current trends. Maybe a setup where glp drugs are nationalized and only used to further under…
100% agree. But that also feels like the elephant in the room somehow. Most western pension systems are stretched to (or beyond) their limits already. I expect that having GLP1-s widely available will extend the life of a LOT of people even further. And then ... what? Im really surprised that nobody talks about that.
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I do not. I’m typing on my phone from a waiting room. I’d probably have fewer incorrect words and awkward sentences if I did.
I see. I got curious because of the correct usage of ’ (instead of the common ')
Interesting. Saying, "there may not be a safe off-ramp," doesn’t feel quite right. The article describes people losing weight while on the drugs and then regaining weight after stopping them. That's not ideal, but it does imply an off-ramp, just with regressions. Compare that to something with no real off-ramp: testosterone replacement therapy. Once you're on TRT, you can permanently suppress your body's own testoste…
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As an experienced polysubstance researcher, that's not exactly accurate. TRT cessation does not inherently cause men to have suppressed hormone levels after. With precautions and extra steps like HCG to maintain leydig cell/testicular function, preventing atrophy, one may safeguard against that risk. Coming off TRT, yes you will have lower levels as your HPTA has been suppressed by exogenous hormones. One may speed u…
mind if I ask what personality and reward seeking effects you experienced?
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As an experienced polysubstance researcher, that's not exactly accurate. TRT cessation does not inherently cause men to have suppressed hormone levels after. With precautions and extra steps like HCG to maintain leydig cell/testicular function, preventing atrophy, one may safeguard against that risk. Coming off TRT, yes you will have lower levels as your HPTA has been suppressed by exogenous hormones. One may speed u…
> GLP-1s are good for impulse and behavioral disorders like ADHD As someone diagnosed with ADHD, I wasn't aware of this (although I haven't had reason to research GLP-1's). Is this just your N=1 or an effect proven in studies?
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As an experienced polysubstance researcher, that's not exactly accurate. TRT cessation does not inherently cause men to have suppressed hormone levels after. With precautions and extra steps like HCG to maintain leydig cell/testicular function, preventing atrophy, one may safeguard against that risk. Coming off TRT, yes you will have lower levels as your HPTA has been suppressed by exogenous hormones. One may speed u…
This reasoning is not flowing through for me. It feels like you are saying: 1. There is an off ramp for TRTs but some people have, “true permanently lowered levels of hormones.” 2. For GLP-1s, “there is no off-ramp, but the only effects I’ve noticed are a return to my baseline.” To clarify my original post, I consider the ability to return to baseline to mean there is an off-ramp and permanently impacted to mean ther…
2. Yes
There is no "off ramp" for GLP-1s in my experience, because the off ramp is so insignificant to not worth a mention. You just don't take another dose after a week has passed from the previous one, and you're back to baseline. Same way there is no off ramp on taking aspirin -- just don't take it.
Earlier quoted context omitted.
As an experienced polysubstance researcher, that's not exactly accurate. TRT cessation does not inherently cause men to have suppressed hormone levels after. With precautions and extra steps like HCG to maintain leydig cell/testicular function, preventing atrophy, one may safeguard against that risk. Coming off TRT, yes you will have lower levels as your HPTA has been suppressed by exogenous hormones. One may speed u…
Thank you for the info on the TRT, I was getting a little worried reading some of the other comments. I'm getting on it due to years of low testosterone. I'm also getting on Zepbound due to years of obesity. The two may be linked, but I need help controlling my appetite and reducing my fatigue.
The obesity likely is the main culprit-- if I had to guess. Fat stores act as sites for testosterone to be aromatized to estrogen -- so if your E2 is elevated that would be a marker.