Earlier quoted context omitted.
Provide a reference please. Which country is that from?
USA, what my wife’s OB told her. 20 years ago.
The OB will give you a list of what you can and can’t take. Tylenol is the only pain reliever you can take.
Paracetamol disrupts early embryogenesis by cell cycle inhibition
91–100 of 217 posts
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#92There is mounting talk of a link between Paracetamol/Acetaminophen/Tylenol and autism.
Some links:
https://hsph.harvard.edu/news/using-acetaminophen-during-pre...
https://jennifermargulis.substack.com/p/why-this-doctor-is-c...
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#93Earlier quoted context omitted.
Yes, https://www.thisamericanlife.org/505/use-only-as-directed The episode shows how even small overdoses of acetaminophen can cause fatal liver damage, while decades of FDA delays and confusing drug labeling left millions of Americans at risk.
Tylenol is very safe if taken as prescribed. The overdose amount is relatively low, but not uniquely low. The alternatives are worse - ibuprofen destroys your stomach lining if taken at the regular dose for too long.
Ibuprofen also increases risk of strokes and NSAIDs have been linked to increased risk of intracerebral hemorrhage. It’s a question of whether benefits outweigh cons on population level and I am not an expert, but recommending ibuprofen over acetaminophen might be over-simplifying things. It depends on the person (their meds, their pre-existing conditions, their genetics etc)
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#94Isn't paracetamol forbidden in the US for pregnant women already? It is in other countries
No it’s the only allowed pain reliever for pregnant women in the US. It’s also allowed in the UK and the EU from what I can tell. What countries are you talking abou?
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#95Earlier quoted context omitted.
This is probably one of those things where the risk is normally small, so small increases cause large changes in percentage. For instance, if spontaneous abortion is normally 1% and smoking increases it to 2%, then that’s a 100% increase. Now, I don’t know the actual numbers, and smoking is just generally not good for one’s health, but I wouldn’t go as far to say things were stacked against you.
Millions of kids have been born to parents who smoked and drank all the way through their pregnancies, especially before the 1970s or so. It raises risks, but doesn’t guarantee bad outcomes.
Many, many more but here's a few you might want to start with:
"The meta-analysis showed a significant association between maternal tobacco smoking during pregnancy and increased risk of ADHD in offspring."
Mohammadian M, Khachatryan LG, Vadiyan FV, Maleki M, Fatahian F, et al. (2025) The association between maternal tobacco smoking during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring: A systematic review and meta-analysis. PLOS ONE 20(2): e0317112. https://doi.org/10.1371/journal.pone.0317112
"Compared with unexposed controls, individuals with PAE reported significantly higher frequencies of problems with hearing, dentition, heart, cancer, gastritis, kidney stones, bladder, diabetes, thyroid, skin, and seizures."
Coles, C.D., Shapiro, Z.R., Kable, J.A., Stoner, S.A., Ritfeld, G.J. & Grant, T.M. (2024) Prenatal alcohol exposure and health at midlife: Self-reported health outcomes in two cohorts. Alcohol: Clinical and Experimental Research, 48, 2045–2059. https://doi.org/10.1111/acer.15441
"Our results indicate that perinatal exposure to maternal smoking is associated with increased risks of CVD events, and such relations are modified by adulthood smoking behaviors."
H., Liang, Z., Wang, H., Cardoso, M. A., Heianza, Y., & Qi, L. (2021). Perinatal exposure to maternal smoking and adulthood smoking behaviors in predicting cardiovascular diseases: A prospective cohort study. Atherosclerosis, 328, 52–59. https://doi.org/10.1016/j.atherosclerosis.2021.05.009
"Our findings support previous findings suggesting the detrimental effects of prenatal binge drinking on child cognition. Prenatal alcohol exposure at levels less than daily drinking might be detrimentally associated with child behavior. The results of this review highlight the importance of abstaining from binge drinking during pregnancy and provide evidence that there is no known safe amount of alcohol to consume while pregnant."
Flak, A. L., Su, S., Bertrand, J., Denny, C. H., Kesmodel, U. S., & Cogswell, M. E. (2014). The association of mild, moderate, and binge prenatal alcohol exposure and child neuropsychological outcomes: a meta-analysis. Alcoholism, clinical and experimental research, 38(1), 214–226. https://doi.org/10.1111/acer.12214
You may not not want to hear this, but let's put it plainly: Prenatal smoking and alcohol is clear and obvious child maltreatment.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#96Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#97Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#98Isn't paracetamol forbidden in the US for pregnant women already? It is in other countries
As far as I can tell from my local health organisations, paracetamol is one of the safest painkillers for pregnant women.
That doesn't make it very safe, but NSAIDs carry well known risks during later stages of pregnancy, and opiods aren't exactly harmless either. Even aspirin carries risk (and aspirin doesn't even work as well compared to other drugs).
As far as I can tell paracetamol is still the first choice for painkillers while pregnant, but only because none of them are completely safe to use. It's probably fine for short term usage, but that also goes for non-pregnant people to be honest.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#99Earlier quoted context omitted.
Millions of kids have been born to parents who smoked and drank all the way through their pregnancies, especially before the 1970s or so. It raises risks, but doesn’t guarantee bad outcomes.
Many, many more but here's a few you might want to start with: "The meta-analysis showed a significant association between maternal tobacco smoking during pregnancy and increased risk of ADHD in offspring." Mohammadian M, Khachatryan LG, Vadiyan FV, Maleki M, Fatahian F, et al. (2025) The association between maternal tobacco smoking during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) in o…
Don’t misunderstand that I’m advocating it.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#100Earlier quoted context omitted.
Not denying that acetaminophen/paracetamol has a horrible therapeutic index, but there are reasons why it is still so widely used. Despite potential hepatoxicity, it is considered the safest pain relief drug (this emerging research notwithstanding) Ibuprofen is not better in every way. For instance ibuprofen, as well as other NSAIDs, is much less gentle on gastrointestinal tract and puts much more strain on kidneys.…
Your comment is fair; obviously I wrote a pretty flippant comment, but the message is largely useful for most people. The fact is that (largely due to the incredible marketing of Johnson & Johnson's Tylenol brand in the US) way too many people think acetaminophen is "safe and effective" when it's actually both pretty unsafe and pretty ineffective. Most people just "pop a Tylenol" by default without realizing it's not…
NSAIDs can cause GI issues if taken with or without a snack.
They reduce production of the stomach’s protective mucous lining. Snacks don’t help with that.
They can also cause kidney damage.
Occasional use for an otherwise healthy person is fine. But Tylenol as long as you are careful not to take too much is generally safer.