Ozempic shows anti-aging effects in trial • Hacker News Board

Re: Ozempic shows anti-aging effects in trial

#91

Post by krisoft » Tue, Aug 05, 2025, 7:39 PM UTC

gryn wrote: post #37

NoMoreNicksLeft wrote: post #27

Earlier quoted context omitted.

>My opinion is to wait long enough to validate there are no long term harms, What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.

I'm a late adopter to most things. my estimate would bigger than others and I would put it at 30-50years. I take smoking as a cautionary tale, in the beginning it was pushed as not just a recreational thing but a healthy activity that bring benefits with papers published to sing praises about it. my parents were even nudged by their teachers/doctors/etc when they were young to try smoking. now we all know that smokin…

> I take smoking as a cautionary tale, in the beginning it was pushed as not just a recreational thing but a healthy activity

While i agree the gist of what you are saying, also important to mention that humans started cultivating tobaco when mamoths still roamed the Earth. There was indeed a concentrated pro-smoking publicity campaign by tobaco manufacturers in the 1930s, but it was hardly “in the beginning” of our tobaco use.

Re: Ozempic shows anti-aging effects in trial

#92

Post by tsol » Tue, Aug 05, 2025, 7:41 PM UTC

morkalork wrote: post #74

kulahan wrote: post #67

Earlier quoted context omitted.

I think many people confuse simple with easy. It IS simple to reduce your weight. There are like, two things you need to do. It is, however, VERY hard to actually do those things.

Even then, limiting calorie intake isn't all that difficult; there's a reason why intermittent fasting took off and so many people were getting results from it.

Not necessarily. Some people respond well too intermittent fasting but not everyone. Some people respond to keto but not everyone. And just because you respond doesn't mean it's gonna take you to where you need to be.

I've always been skinny but for some reason I've gained weight recently. Even with keto, intermittent fasting, tirzeptide, and workouts twice a week I have only lost 5 lbs in months. When I was skinny and forgot to eat, I would feel a little crappy but still could function. Now I begin to feel incredibly depressed, I can't sleep nor focus. This solidified it to me that there's a circuit in your brain that controls feeding and if it's out of whack it'll punish you until you eat. Dieting takes months and no one can go that long without sleep. So it's still a practical problem, its just hard to see if your system is well calibrated.

Re: Ozempic shows anti-aging effects in trial

#93

Post by thaumasiotes » Tue, Aug 05, 2025, 7:41 PM UTC

noah_buddy wrote: post #20

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

> Gluttony or overeating are not the sin, but being fat.

This is a strange thing to say. If you do something normal, and you end up in a normal state, why would that be a moral failing? There's no such thing as "overeating". Different people eat different amounts. The same person eats different amounts at different times.

> (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve.

This is incoherent. If you believe that being fat is a sin, but that the things you do that make you fat are not sins, then a miracle cure that makes you thin removes the only sin you were committing. You can't be unworthy if you're not fat. In order for a miracle cure to be "cheating", it is necessary that the sin is in the behavior and not the result.

Re: Ozempic shows anti-aging effects in trial

#94

Post by angmarsbane » Tue, Aug 05, 2025, 7:41 PM UTC

kjkjadksj wrote: post #26

pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

I notice it in people who have never been the weight that they're suddenly walking around as, with them it often looks overdone, too thin for their features etc, but in those who have used it to get back to weights where I've seen them before...I didn't guess. They had to tell me.

Re: Ozempic shows anti-aging effects in trial

#95

Post by const_cast » Tue, Aug 05, 2025, 7:44 PM UTC

kjkjadksj wrote: post #26

pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

That's just what happens when you get skinny. People who have always been skinny just look sickly always so we don't notice.

Re: Ozempic shows anti-aging effects in trial

#96

Post by thaumasiotes » Tue, Aug 05, 2025, 7:44 PM UTC

kmeisthax wrote: post #17

jbentley1 wrote: post #16

Earlier quoted context omitted.

Naturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.

As a talented engineer, I hate AI coding because it doesn't do what it says on the tin. If GLPs made people hallucinate weight loss that wasn't actually happening, I'd be angry about them too.

Ever seen "Shallow Hal"?

Re: Ozempic shows anti-aging effects in trial

#97

Post by cjbgkagh » Tue, Aug 05, 2025, 7:45 PM UTC

kulahan wrote: post #88

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

[flagged]

Semaglutide is a signaling peptide, these are basically in a different class of medication that has traditionally been largely ignored. Partly due to difficulty defending patents for a class of medication that the body produces naturally, I.e. the instructions are in the DNA. Even if a drug company patents one GLP-1A they can’t patent all of them and any of them will work much the same way.

Because it’s a naturally occurring signaling peptide there already exist people who have too much of it and too little of it due to normal genetic variation.

Re: Ozempic shows anti-aging effects in trial

#98

Post by HocusLocus » Tue, Aug 05, 2025, 7:47 PM UTC

tzs wrote: post #76

HocusLocus wrote: post #55

I guess maybe I'm one of the few who consider "reversing 3.1 biological years" to be a personal insult. Something that polled well in a group of pre-kindergarteners. What happened, some statistical bloodwork metric was tortured to produce such a claim? A mouse population survived the lab a little longer?

Here's an article that answers your question [1]. It in the second bullet point near the top. [1] https://trial.medpath.com/news/5c43f09ebb6d0f8e/ozempic-show...

Yes, epigenetic clocks discovered in 2010 and even the researcher who discovered them might feel insulted by the phrase of a prescription drug declaring "reverse biological aging 3.1 years"

Re: Ozempic shows anti-aging effects in trial

#99

Post by const_cast » Tue, Aug 05, 2025, 7:47 PM UTC

morkalork wrote: post #74

kulahan wrote: post #67

Earlier quoted context omitted.

I think many people confuse simple with easy. It IS simple to reduce your weight. There are like, two things you need to do. It is, however, VERY hard to actually do those things.

Even then, limiting calorie intake isn't all that difficult; there's a reason why intermittent fasting took off and so many people were getting results from it.

Ive heard this same sentence, verbatim, repeated throughout the course of decades for particular fad diets. Decades.

Re: Ozempic shows anti-aging effects in trial

#100

Post by cjbgkagh » Tue, Aug 05, 2025, 7:47 PM UTC

alistairSH wrote: post #38

throwforfeds wrote: post #31

Earlier quoted context omitted.

I've had a few friends on it. They definitely lost weight, but the GI issues were too much and when they went off of it they gained it all back.

I've read (anecdotes from people in the fitness/body-building space) that the default dosing could be too high for many people. And the side-effects seem to ramp up with the dose. IE, if you're getting weight loss at 1/2 the default dose, you might want to stay there, even if your MD wants you to increase to the default. [default uses loosely here - people build up from a low dose over the span of weeks/months] And t…

Very much the default is too high and the bro-science was indeed early on this. I’m super sensitive and had the bad negative reactions at 1/10th the starting dose. It’s been a wonder drug for me though, finally able to put my life back together after ME/CFS all but destroyed it.