Earlier quoted context omitted.
https://zio.dev/reference/stm/
> Implication of Using STM Running I/O Inside STM— There is a strict boundary between the STM world and the ZIO world. This boundary propagates even deeper because we are not allowed to execute arbitrary effects in the STM universe. Performing side effects and I/O operations inside a transaction is problematic. In the STM the only effect that exists is the STM itself. We cannot print something or launch a missile ins…
Scala doesn't enforce purity like Haskell though so it wont stop you if you call some normal Scala or Java code with side effects. In practice its not a problem because you're wrapping any effectful outside APIs before introducing them into your code.