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GLP-1 drugs: An economic disruptor? (2024)

wildfirelabs.substack.com

91–100 of 553 posts

Re: GLP-1 drugs: An economic disruptor? (2024)

#91
I think an angle not covered is that the "impulse economy" actually degrades impulse control. Advertising, social media feeds, etc are all hammering away at people's willpower, and getting is addicted to giving in to impulses. If these things disappear, maybe even people who aren't on these drugs would have more impulse control.

Re: GLP-1 drugs: An economic disruptor? (2024)

#92
post #55

Earlier quoted context omitted.

Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. The effects are very worth it for people weighing them against heart disease and mobility issues. It's not a Faustian bargain, it's all right on the tin. When you stop taking it the effects go away. If you want to be indulgent and it fits your lifestyle you can reversibly make that decision. T…

After using them, I think GLP-1’s will eventually be rebranded as a weight management / weight maintenance drug rather than a weight loss drug in order to appeal to the masses. It’s a very interesting feeling to feel like you’re in full control of what you eat, not influenced by random cravings or hunger. In my case I’m planning to only stay on it another month or 2 to drop 10lbs. I can easily see people cycling on/o…

A rebranding to a non-prescription drug will depend on how the prevalence × severity of side effects [0] turns out longer-term. I hope that you are right, but it seems too early to tell.

[0] https://www.sciencedirect.com/science/article/pii/S266736812...

https://www.gov.uk/drug-safety-update/glp-1-receptor-agonist...

Re: GLP-1 drugs: An economic disruptor? (2024)

#93
post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I resonate with your comment about appetite loss. It is surprising how much it has affected my happiness, to have this few times a day pleasure taken away.

A month ago I suffered through a norovirus infection, the first time for me. In three days I lost six pounds (my BMI is 21.2 now). At first I wasn't surprised or worried -- after all, I had emptied out my digestive tract and was dehydrated. But a month has gone by and my appetite has been AWOL. I've lost another pound (5'11" @ 152 lbs). I have an appointment next week with my doctor's PA to see if something else is going on.

The taste of food is the same, but the craving is lacking. When I eat, my guts are telling my brain it is time to stop eating, as if I had eaten a pound of mashed potatoes only an hour ago.

Re: GLP-1 drugs: An economic disruptor? (2024)

#94

Is there a term for this style of writing? It's like a longform linkedin post. I don't mean this as a criticism, it just seems like written language is evolving to better capture our diminishing attention spans.

TLDR: Dont eat so much, you wont be so fat.

Re: GLP-1 drugs: An economic disruptor? (2024)

#95
This class of the drugs is the biggest thing to happen in medicine in a long time in my view (as somebody who does not work in the industry.)

Is there any data to show they have an effect on other addictive behaviours, like drug addiction, social media addiction, caffeine addiction?

Re: GLP-1 drugs: An economic disruptor? (2024)

#96
post #37

The author is assuming that everyone will proactively start taking this drug. But I don't understand why? If Jerry is not obese, why would Jerry randomly start taking an anti-obesity drug?

It is a bit of a silly proposition, considering that 40% of Americans are obese, and many of that population cannot afford $800-$2000 prescriptions.

It's not silly at all. In 15-20 years this stuff will be <$100 for weeks of use. For many people $800 dollars is less than the they spend on food in the same time

Re: GLP-1 drugs: An economic disruptor? (2024)

#97

Earlier quoted context omitted.

> Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. Why do you think this? I agree that people who have associated risk factors should be prioritized, but if there's enough for everyone why wouldn't we give it to anyone who wants it?

Because anorexia exists it would do harm to completely unregulate access to appetite suppressants. Someone should be looking out for people who would willingly wither away.

I don't think anyone is suggesting it should be over the counter? Of course a doctor should monitor you while you are on it. We shouldn't give it to people who would use it to deepen a mental health diagnosis.

Those concerns have nothing to do with the fact that it's ok for people to choose to start or stop medications if they would prefer (supplies allowing).

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