91–100 of 107 posts
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>It won't work as well if you insist on eating a pint of ice cream three times a day. Yeah, good luck with that. GLP-1 agonists reduce your desire for, and for many people, your ability to consume things like “a pint of ice cream three times a day.” That’s kinda the point.
The sarcasm in my reply did not come across it would seem. "No free lunch" does not in any sense imply that there are no positive-sum decisions to be made.
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Sod off. Your take on overweight being ”willfully and knowingly overeating” is ignorant and naive beyond recourse.
There's nothing ignorant about it, you don't get to be obese by accident. Sorry, that's just the truth.
Don't worry. You'll still get to feel superior about not being fat - you can just proclaim loudly that you did it without a GLP-1. Those that think like you will give you the applause you're looking for, I'm sure. And everyone else can roll their eyes and move on with their day.
"Not liking" medication that greatly improves people's lives and greatly reduces their risk of early death just because you think it's the "easy way" and "not doing the work" makes you an asshole. Rooting for them to have significant side effects also makes you an asshole.
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Well, let's not give you any medication for any disease you are afflicted with. It's an easy way out. Get a bacterial infection? Should have been cleaner. Get a virus? Why you expose yourself. Develop cancer? We know there are millions of lifestyle choices that push the needle towards development bit by tiny bit, why didn't you avoid all of those? All of these are nature's price for not doing the work. Why are you ta…
Catching a disease is not the same as willfully and knowingly overeating to the point of obesity. That is a very poor comparison.
But you also ignored all of the other things you do every day that are the easy way out.
Interesting synchronicity of seeing this article. I just had an optometrist appointment this morning and my glasses prescription updated/renewed. The only medication I am on is Ozempic for weight management, ~8 months, lost ~40 lbs so far. My old prescription was -1.75 / -1.0 (about 5 years ago), and my new one is -0.5, -0.5. My optometrist said it was unusual but likely due to having blood glucose under control as i…
Isn't that an improvement, in your case?
Interesting synchronicity of seeing this article. I just had an optometrist appointment this morning and my glasses prescription updated/renewed. The only medication I am on is Ozempic for weight management, ~8 months, lost ~40 lbs so far. My old prescription was -1.75 / -1.0 (about 5 years ago), and my new one is -0.5, -0.5. My optometrist said it was unusual but likely due to having blood glucose under control as i…
Earlier quoted context omitted.
There's nothing ignorant about it, you don't get to be obese by accident. Sorry, that's just the truth.
Basically no one chooses to be obese. It happens bit by bit over time, with small poor choice after small poor choice stacking up. Don't worry. You'll still get to feel superior about not being fat - you can just proclaim loudly that you did it without a GLP-1. Those that think like you will give you the applause you're looking for, I'm sure. And everyone else can roll their eyes and move on with their day. "Not liki…
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> Given that sustainable, side effect free ways to lose weight exist (with many additional benefits) Just because it exists doesn't mean it's statistically applicable to a population of people. I've yet to see real evidence that on a population scale, sustainable and side effect free ways to lose weight exists at a statistically significant level. If you're 100+ lbs overweight and you lose it all without any medical…
Not to mention that the human body is completely opposed to losing weight, and will do anything it can to convince you that what you really need to do is to gain it back.
My wife has wanted me to get on ozempic, but I'm actually scare of side effects, and the cost is atrocious in the US.
I really don't like these medicines that give people who indulge themselves excessively an easy way out. Maybe these side effects are nature's price for not doing the work.
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Basically no one chooses to be obese. It happens bit by bit over time, with small poor choice after small poor choice stacking up. Don't worry. You'll still get to feel superior about not being fat - you can just proclaim loudly that you did it without a GLP-1. Those that think like you will give you the applause you're looking for, I'm sure. And everyone else can roll their eyes and move on with their day. "Not liki…
You are choosing to be obese by making those choices repeatedly in spite of the obvious consequences. It didn't sneak up on you out of nowhere. Calling me an asshole is beside the point, it's just a word for a person who says things that are true that people don't want to hear.
And no, you're not an asshole for saying that people hold some responsibility in getting fat. You're an asshole because you're wishing further harm on them vs. them having a safe and effective treatment for it. Even if becoming obese wasn't a complex and multifaceted topic (and this is well established science, not some fat-apologist bullshit), even if people just pushed a button that said "make me fat" for some reason, we should all wish for them to have as easy, safe, and effective of a method as possible for returning to a healthy body weight.
What possible moral justification could you have for literally wishing people will have negative health outcomes because they want to use medication to assist them in their weight loss?
If you literally cannot stop yourself from being obese any other way, then Ozempic and similar may be a good choice. But the side effects are large. You can never, ever stop taking it. We don't know what being on it for decades causes. There are anecdotes that it numbs you out emotionally. There are no shortcuts in life. There is always a tradeoff.
> You can never, ever stop taking it. You can't stop taking it without gaining the weight back (unless the lifestyle change sticks), but everybody stops taking it in the medium term. The side effects are horrible and stack up over time. We'll start seeing the miserable condition of very long-term users (or maybe, hopefully, their bodies will reach an equilibrium!), and we will be able to use the sacrifice of their he…
Some people experience significant side effects. Many people do not. Tirzepatide seems to induce even fewer side effects in general than semaglutide.
> We'll start seeing the miserable condition of very long-term users (or maybe, hopefully, their bodies will reach an equilibrium!), and we will be able to use the sacrifice of their health in order to understand how better to counteract the long-term side effects, or to get hints on how to design the next class of miracle weight loss drugs.
I'm active on several GLP-1 related forums. On those, people near-universally report side effects lessening over time, from those that have significant side effects to begin with.
The next generation of drugs is arriving now. Eli Lilly is finishing up their initial phase 3 trials for retatrutide at EOY, and in a matter of months I've seen it reduce my ALT levels from edging towards an indication of NAFLD to right in the middle of optimal. Preliminary results from the trials in general seem very positive, so I imagine FDA approval will come later '25/early '26, though the glucagon receptor activity does seem to increase resting heart rate in many people (including myself, though tirzepatide did as well, to a lesser degree.)
> I'm never going to take them. There are better ways to lose weight, with no side effects, and they slowly and stably got me from a 28 BMI to a 22 BMI. I will push the people I love towards those rather than to a set of powerful, expensive drugs with wild side effects
I would agree if you have success in losing weight with other methods, there's not a strong reason to go on the GLP-1s. We do have some evidence that they have other positive health benefits even without the weight loss, but there are some side effects, yes, and we of course do not strongly know what happens if you take these for decades on end. On the other hand, we know that improving diet and increasing exercise are basically all net positives, outside the minimal injury risk that comes with exercise.
I do think you are overstating the side effects, though. There seems to be some small risk of sight issues, though I would like more data here - we know that diabetes is significant risk factor for eye disease, and I'm curious how well these results will be replicated in general, and how well they translate to non-diabetics taking them purely for weight loss. We've also seen thyroid cancer in rodent studies, and while so far no human studies have found an increase, I wouldn't be surprised if there is some risk increase for humans.
> somebody invented a week ago.
We're actually about two decades in on the GLP-1 class of drugs being in-use by humans, but obviously semaglutide and tirzepatide have really ratcheted up adoption.