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Weight-loss drug found to shrink muscle in mice, human cells

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Re: Weight-loss drug found to shrink muscle in mice, human cells

#91

Post by kbos87 »

phil21 wrote: post #75
zemvpferreira wrote: post #50

Earlier quoted context omitted.

>Losing weight without losing muscle mass is very hard. I was with you up to here. In my experience it's easy to maintain a huge proportion of your lean tissue during a weight loss diet: Do some resistance training, get some protein, and don't lose weight too quickly. There's no need to go to the extreme of a PSMF - which will still have you lose a bunch of muscle on account of being too big a deficit. If you can kee…

Bodybuilders I know seem to have a a very difficult time keeping their muscle gains while on a cut, I don’t know why someone who is not in a gym 5+ days a week and on an extremely optimized heavy protein diet measured down to the gram would expect otherwise. Is it possible to go very slow and keep most of your lean muscle mass? Sure. Is it practical? I have my doubts. Part of the effectiveness of these drugs - for me…

It isn't hard to imagine that the last 10% of mass a bodybuilder has added was hard won and easily lost. That isn't representative of most people.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#92

Post by throwaway2037 »

throwup238 wrote: post #31
cm2187 wrote: post #13

> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle That's the sort of headlines that smells like bullshit to me. My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are…

The next line of the article after that 40% quote: > Carla Prado, a nutrition researcher in the Faculty of Agricultural, Life & Environmental Sciences and lead author on the commentary, explains this rate of muscle decline is significantly higher than what is typically observed with calorie-reduced diets or normal aging and could lead to a host of long-term health issues — including decreased immunity, increased risk…

    > Losing weight without losing muscle mass is very hard.
Lots of amateur body builders can do it. There are whole training guides about how to lose body fat, but maintain as much muscle mass as possible. Granted, they are probably a minority because they have higher discipline and motivation than the average population.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#94

Post by uxp100 »

throwup238 wrote: post #31
cm2187 wrote: post #13

> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle That's the sort of headlines that smells like bullshit to me. My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are…

The next line of the article after that 40% quote: > Carla Prado, a nutrition researcher in the Faculty of Agricultural, Life & Environmental Sciences and lead author on the commentary, explains this rate of muscle decline is significantly higher than what is typically observed with calorie-reduced diets or normal aging and could lead to a host of long-term health issues — including decreased immunity, increased risk…

Nutrient deficient, sure, protein deficient? Probably not.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#95

Post by llamaimperative »

throwaway2037 wrote: post #90
llamaimperative wrote: post #63

Earlier quoted context omitted.

> The rather obvious problem is that these GLP1 agonists don't improve your diet My understanding from initial anecdotes is this is actually literally wrong. Which was surprising to me, too. But people on GLPs tend to prefer more nutritious food (high protein and high fiber). I'm not sure if this has been studied directly in clinical trials yet but I know that food manufacturers have been reorienting their products t…

This observation is very interesting. I hope that it is studied more closely and we can read some peer reviewed research on the matter. One idea popped into my head: Could part of the cause be that people's mood and self-esteem improves during (GLP1 agonist-induced low hunger) weight loss? TL;DR: If you feel like shit about yourself (and body), then you are more likely to eat poorly, and vice versa.

That's an excellent hypothesis. Wouldn't be surprised at all if that was a component!

Re: Weight-loss drug found to shrink muscle in mice, human cells

#96

Post by talkingtab »

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well.

What is the current comment receiving most of the comment?

"That's the sort of headlines that smells like bullshit to me"

That's the sort of comment that smells like bullshit to me. What kind of place is this?

Many times I find the posts on HN interesting, but increasingly these kind of comments make me wonder about Y Combinator. Is this really the best they can do?

And for us readers who are supposed to be so called hackers, is this the best we can do?

Re: Weight-loss drug found to shrink muscle in mice, human cells

#97

Post by throwaway2037 »

turbojet1321 wrote: post #87
zemvpferreira wrote: post #50

Earlier quoted context omitted.

>Losing weight without losing muscle mass is very hard. I was with you up to here. In my experience it's easy to maintain a huge proportion of your lean tissue during a weight loss diet: Do some resistance training, get some protein, and don't lose weight too quickly. There's no need to go to the extreme of a PSMF - which will still have you lose a bunch of muscle on account of being too big a deficit. If you can kee…

It's notoriously hard to lose fat without also losing muscle. That's why bodybuilders bulk well past their target muscle mass before they cut for competition. I agree that you can do a lot to mitigate it through protein intake and resistance training, but you'll almost certainly still lose muscle when you're in caloric deficit, regardless.

I'm not sure why this is so heavily downvoted. You raise some good points. I would add: The era of comical bulking is coming to an end. More and more scientific literature points to modest calorie surplus is the key to muscle gain (along with regular weight training).

Re: Weight-loss drug found to shrink muscle in mice, human cells

#98

Post by turbojet1321 »

twelve40 wrote: post #76
renewiltord wrote: post #45

Earlier quoted context omitted.

One of my friends has tried many fad diets, etc. and he finally just went and paid cash for a GLP-1 and he's lost a lot of weight and is feeling much better. If I were in that situation, I would just do the same.

bringing it down is not even half the battle, it's what happens next is the more interesting part

You keep taking the GLP1 agonist, otherwise you gain the weight you lost.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#99

Post by sheepscreek »

pottertheotter wrote: post #78
throwup238 wrote: post #31

Earlier quoted context omitted.

The next line of the article after that 40% quote: > Carla Prado, a nutrition researcher in the Faculty of Agricultural, Life & Environmental Sciences and lead author on the commentary, explains this rate of muscle decline is significantly higher than what is typically observed with calorie-reduced diets or normal aging and could lead to a host of long-term health issues — including decreased immunity, increased risk…

This is true. I just lost 30 pounds over 3 months and 17% was muscle. I thought I was eating a lot of protein, but I’ve upped it today. I did an InBody scan the day I started (8/21) and just happened to have done my second one this morning.

I don’t think we can expect to retain 100% of muscle mass, and losing just 1/5th sounds like a good outcome.

I’ve understood that generalizing anything in today’s time is a losing game. I know many people with IBS/GI issues and I am also sure they have different underlying causes. Our gut biome and how digestion works in general needs to be researched much more.

I don’t know why progress has generally been so slowly on that front. For instance, GLP-1 was discovered in the 1970s. It took us another 40 years to commercialize it in the form of Semaglutide and another 10 years to get it ready for human consumption.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#100

Post by throwaway2037 »

twelve40 wrote: post #70
zemvpferreira wrote: post #50

Earlier quoted context omitted.

>Losing weight without losing muscle mass is very hard. I was with you up to here. In my experience it's easy to maintain a huge proportion of your lean tissue during a weight loss diet: Do some resistance training, get some protein, and don't lose weight too quickly. There's no need to go to the extreme of a PSMF - which will still have you lose a bunch of muscle on account of being too big a deficit. If you can kee…

> In my experience it's easy > Do some resistance training, get some protein jeez, if people actually did that they wouldn't need the drug to begin with

I must disagree with your comment. Personally, I have witnessed so many people struggle for years with their weight. Being overweight and struggling to lose weight must be a 50 factor model: Multiple social, economic, and mental/physical health factors. These GLP1 drugs really are a game changer.
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