Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

nbcnews.com

Post reply on HN
Print view View original

91–100 of 214 posts

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#91

Post by Zelphyr »

mbostleman wrote: post #22
voidfunc wrote: post #19

Earlier quoted context omitted.

Gonna be fun discovering what side effects it causes in 20 years tho.

Exactly. I see all these breathless claims of new uses and how wonderful this drug is and wonder when the other shoe is going to drop.

You're getting downvoted here but I think there is precedent behind your statement. History is littered with weight loss drugs that had to be pulled because the shoe eventually dropped. Usually that was addiction or death which, admittedly, neither have been shown in the GLP-1's but, given the history of weight loss drugs, it's not unreasonable in my opinion to be cautious.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#92

Post by BaculumMeumEst »

voidfunc wrote: post #19
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

Gonna be fun discovering what side effects it causes in 20 years tho.

- Significantly increased mortality risk

- Higher rates of cardiovascular disease

- Type 2 diabetes

- Sleep apnea and breathing problems

- Osteoarthritis due to excess pressure on joints

- Multiple types of cancers (colon, breast, endometrial)

- Depression and anxiety from social stigma

- Reduced mobility and quality of life

- Higher medical costs (~$1,429 more annually per person)[1]

- Decreased workplace productivity

- Shorter life expectancy (can reduce by 5-10 years)

Oh no wait, sorry, those are the effects of obesity.

[1] https://pubmed.ncbi.nlm.nih.gov/19635784/

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#93

Post by throwaway041207 »

93po wrote: post #51
throwaway041207 wrote: post #36

Earlier quoted context omitted.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…

do you have adhd, and do you think your drinking is at all related to adhd/lack of executive function? just curious, not implying.

I do not have ADHD. I am not sure exactly why I drink so much -- there are a number of alcoholics on both sides of my family, but I also spent many years drinking in bars in a big city, living a very social life. During COVID I became much more of a solitary drinker and over the last five or so years I have drank out of a sense of malaise. Every morning became the day I was going to take a break and every night there was an excuse to start drinking again.

The strange thing about GLP-1s effect on my desire to drink is how it manifests: I just don't care about drinking. I actually _could_ drink and be fine I think, I haven't tested it. I don't go through life with the burden of the knowledge of my own addiction. I don't have to be vigilant about triggers and self-assess my actions. I just don't drink.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#94

Post by [deleted] »

curious_cat_163 wrote: post #11

> nationwide database of electronic health records (EHRs) of 116 million US patients. If you are expert in this space: Is such a dataset available publicly? If so, are there examples of other studies that have used this? Where does one go to read more about the mechanism of this study? Thanks!

[deleted]

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#95

Post by RobotToaster »

thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

They don't have to buy the patent, they can issue a compulsory licence for it https://en.wikipedia.org/wiki/Compulsory_license#United_Stat...

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#96

Post by llamaimperative »

VyseofArcadia wrote: post #85
throwaway041207 wrote: post #36

Earlier quoted context omitted.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…

> barring any life threatening long term side effects There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side ef…

> There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects.

We've been prescribing GLP-1s for almost 20 years now. Not to say they all should behave identically, but from a Bayesian inference perspective these things really do appear to be quite safe.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#97

Post by jewayne »

Someone1234 wrote: post #60
nordsieck wrote: post #31

Earlier quoted context omitted.

> With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting. So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is qui…

> So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you... It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Card…

Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss?

In other words, would a thin, metabolically healthy person benefit from taking semaglutide?

So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic people.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#98

Post by Zelphyr »

cynicalpeace wrote: post #63

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

I think the food manufacturers are culpable here, and "manufacturer" is really the best word to use. They're more like chemists cobbling together edible compounds than farmers growing things that provide nutrition.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#99

Post by VyseofArcadia »

llamaimperative wrote: post #96
VyseofArcadia wrote: post #85

Earlier quoted context omitted.

> barring any life threatening long term side effects There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side ef…

> There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. We've been prescribing GLP-1s for almost 20 years now. Not to say they all should behave identically, but from a Bayesian inference perspective these things really do appear to be quite safe.

https://www.drugwatch.com/legal/ozempic-lawsuit/

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#100

Post by imp0cat »

steeeeeve wrote: post #39

Get skinny and keep my brain? No thanks. At some point this roller coaster ride needs to end.

You might think that these two (get skinny and lower Alzheimer's risk) are the only two benefits, but don't forget that this drug is also pretty much the end of the road for the "More People Should Be Fat!/HAES movement".

https://en.wikipedia.org/wiki/Health_at_Every_Size

And good riddance I say!

Post reply on HN