Earlier quoted context omitted.
Interesting are systems like Xerox PARC Workstations (Mesa, Cedar, Smalltalk, Interlisp-D), ETHZ Oberon, Inferno, Apollo/Domain, Tru64, QNX.
QNX it's another Unix in the end any the Photon GUI it's nothing odd to any KDE/Windows 2000 user. Smalltalk has issues on exporting your software to be run under a standalone way. On Interlisp, there's Mezzano, a Common Lisp OS, but it needs some tweaks and optimizations. Oberon UI wise it's the same as Acme under p9/9front/p9port. On Inferno, 9front and Go superseded it in some ideas.
What issues?