Live data from Hacker News

Brain waves appear to wash out waste during sleep in mice

jamanetwork.com

91–100 of 270 posts

Re: Brain waves appear to wash out waste during sleep in mice

#91
Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion.

No wonder Musk is interested in this area of research.

This line indicates that with an optigenetic implant you can substitute sleep with something more efficient.

Re: Brain waves appear to wash out waste during sleep in mice

#93

Earlier quoted context omitted.

I think the point of replacing sleep is to save time. Replacing hours of sleep with hours of yogo or mediation seems like you are not gaining anything.

I think the point would be if you could replace ~8 hours of sleep with ~1-2 hours of meditation. I very much doubt it's a like-for-like replacement, but it might go some way to reducing the need for full sleep, e.g. 2 hours meditating + 2 hours sleeping = 8 hours sleeping.

Is the idea that yoga/meditation are more efficient than sleep at redistributing the cerebral fluid? That would be very surprising.

Re: Brain waves appear to wash out waste during sleep in mice

#94

After learning this and reading about lion’s mane reversing plaque induced dementia in rats I started taking it as “brain washing detergent” before bed. It gives me some wildly vivid dreams and I always wake up more refreshed.

How much?

Re: Brain waves appear to wash out waste during sleep in mice

#95
post #47
post #37

Earlier quoted context omitted.

I think the point was that every member of the public should have access to publicly funded research at least through the university's website, rather than at least everyone currently in universities should have access.

I agree but I also know (as a university employee) that the reason they don’t do this is because then they would have to pay for and manage the hosting of hundreds of thousands of articles. From the university’s perspective, managing and hosting articles is exactly what publishers do, so universities cede that work to publishers. What is needed is a public database of all publicly-funded research.

Hosting is a long-solved problem. High-quality repositories have provided free, universally accessible document hosting to the academic world for decades.

The arXiv is a nonprofit organization run by Cornell that hosts preprints, and I wouldn't be surprised if it holds more stuff than all the for-profit publishers combined at this point. The barriers to uploading on the arXiv are very low - all you need is to be at a recognized academic institution or endorsed by someone who works for one.

Resources like arXiv have made official publishing largely superfluous for spreading knowledge in the parts of academia that understand and care about the value of spreading knowledge for free. Analogous archives exist for (at least) biology, medicine, psychology, and economics.

https://info.arxiv.org/about/index.html

Re: Brain waves appear to wash out waste during sleep in mice

#96

So, if we could induce those brain waves we wouldn't need sleep? Maybe in the future our AirPods will have a "rejuvenate" feature which plays tones that cause sleep like brain waves to go through and clean out our neurons. Probably not... I think our brains are like LLMs. We train them on sensory input we perceive over time, building up a data model that is unique to us. The models may generate similar results, but e…

I'd think that the brain isn't the only part of the human body that needs sleep/rest. Becoming immobile for such a long amount of time must have a much larger systemic purpose given that this is how our bodies evolved.

Your spine contracts during the day and releases while you sleep at night.

Re: Brain waves appear to wash out waste during sleep in mice

#97

Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. No wonder Musk is interested in this area of research. This line indicates that with an optigenetic implant you can substitute sleep with something more efficient.

I'm sorry but your comment is incredibly I'll informed.

Not only because you think Musk is any where near the leader in the implant space, but more so that you don't understand optogenetics. The device referenced here was transcranial (i.e., non-invasive) but regardless optogenetics requires tagging specific neurons with an opsin (usually via viral vector).

I'm sorry for being curt but this is the 4th or 5th neuroscience post in the last 72h that HN have blasted with shit takes. If I wanted misunderstood science I'd revive my Reddit account.

Re: Brain waves appear to wash out waste during sleep in mice

#98
post #31
post #5

Earlier quoted context omitted.

I can't find free access to the full paper, but here's the abstract (afraid I'm not knowledgeable enough to add to or explain any of it): " The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitud…

>Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Sounds like unsync'd brain waves, (being awake) impedes cerebrospinal fluid flow through the brain. When asleep, neurons sync their action potentials, acting like a ionized fluid pump, moving old dirty cerebrospinal fluid out, and allowing new, clean in.…

As someone in this field (research field not football field) I'd say that is an excellent layman explanation.
Post reply on HN