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mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

bessstillman.substack.com

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Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#91

Post by millzlane »

georgeplusplus wrote: post #83
epistasis wrote: post #53

Earlier quoted context omitted.

> What makes an mRNA vaccine more appealing than a protein-based one? Having worked on the same targeting mechanisms for protein based vaccines meant to be personalized cancer therapies, and having followed the mRNA vaccines with envy, the benefits are absolutely massive. But there's not a single alternative. In comparison to each type: Short peptides injection are worse because: minimal immune stimulation, less of a…

>>> But mRNA vaccine skepticism has to be the stupidest "skepticism" and falsehoods I have ever seen of a new technology. To be fair the media and government are more to blame. By attacking and trying to silence the skeptics during COVID only proved to make what you said worse. You wont make a very attractive product by shaming, deriding, or forcing someone into taking said product that deals with their health.

I don't see how you can convince a skeptic who doesn't have the same knowledge as say a educated professional working on vaccines.

Either the skeptic needs the same level of education or an explanation from someone they trust with the level of education needed. You can't convince the skeptics with a sound byte. If they truly believe the government has it out for the entire country. I don't know where you would even begin.

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#92

Post by Izkata »

azangru wrote: post #9

> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…

Don't forget reverse transcription into free-floating DNA. That's much more stable and can last a long time, and it was confirmed in a lab back in 2021 or 2022 that our liver cells are capable of doing it with the Pfizer mRNA covid vaccine.

There was another study last year on long covid that found some vaccine-specific spike proteins persisting weeks or months after they should have degraded/been removed by the immune system, but IIRC they didn't find a reason why.

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#93

Post by Izkata »

amluto wrote: post #59
thehappypm wrote: post #55

Earlier quoted context omitted.

The covid mRNA vaccines were wildly effective at the original covid strain—95%. But respiratory viruses mutate like crazy.

They were wildly effective for a few months after being given. We don’t know how well they would continue to work in the absence of mutation. But it’s worse than that: the revised vaccines appear to be nowhere near as effective even against strains closely related to those which they target. As a somewhat plausible mechanism, repeated doses have been shown to induce IgG4 production, which non-mRNA vaccines don’t seem…

> repeated doses have been shown to induce IgG4 production

I have a strong suspicion that this finding explains some if not all of the weird results with these vaccines.

* The 95% effective was a measurement solely of sickness, not infection. At the time this was reported, we had no idea if this meant it prevented infection/improved the immune response (good) or suppressed the immune response so we didn't develop symptoms (bad).

* Tons of countries had huge infection spikes just a couple months after reaching high vaccination rates.

* "Long Covid" seems to have become far more prevalent after the vaccines than before.

Here's what I think is happening: The IgG4 finding is key in explaining all of these. It suppresses the immune response, which would allow the virus to run wild without any immediate symptoms (95% initial efficacy). This could cause small amounts of damage that accumulate into Long Covid (why it's associated with infection but seems more prevalent in vaccinated people), as well as turn the vaccinated into asymptomatic spreaders (the high infection spikes).

Personally, I think mRNA vaccines were a complete failure.

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#94

Post by thehappypm »

amluto wrote: post #59
thehappypm wrote: post #55

Earlier quoted context omitted.

The covid mRNA vaccines were wildly effective at the original covid strain—95%. But respiratory viruses mutate like crazy.

They were wildly effective for a few months after being given. We don’t know how well they would continue to work in the absence of mutation. But it’s worse than that: the revised vaccines appear to be nowhere near as effective even against strains closely related to those which they target. As a somewhat plausible mechanism, repeated doses have been shown to induce IgG4 production, which non-mRNA vaccines don’t seem…

The new vaccines are always outdated by the time they get to market, it just mutates too fast. For example Omicron emerged in November 2022, and booster shots for Omicron weren’t available until far later. And now the disease is much more diverse.

No vaccine technology will be able to solve that on its own. There would need to be a significant change in risk tolerance of approving and manufacturing vaccines and deploying them on a rapid timescale.

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#95

Post by CyberDildonics »

3q34D5b7pR5H8k6 wrote: post #89
CyberDildonics wrote: post #88

Earlier quoted context omitted.

You posted insane conspiracy theories with no evidence and lots of the generalizations you made are completely contradicted by mountains of real evidence, what did you expect to happen?

[flagged]

You linked a 4 hour video without even giving specific times. You wouldn't accept that as evidence if someone told you it contradicted everything you said, so why would you expect people to accept that as evidence of things like "rewriting people's genome" or "causing turbo cancer" ?

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#96

Post by hitpointdrew »

tux3 wrote: post #48
azangru wrote: post #9

> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…

The mRNA vaccine mostly stays near the site of injection: your arm. This is why your arm mostly aches, and the rest of your body not so much. A bunch of cells there will die, because your immune system much prefers an innocent cell dead than a infected cell continuing to multiply. But you have plenty of cells. Really quite a lot. So it is entirely worth it. We can try to optimize how much protein cells will make from…

> The mRNA vaccine mostly stays near the site of injection: your arm.

This patently false, and medical disinformation. It is proven with the Covid vaccines that it spreads to the entire body.

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#97

Post by dang »

pangolinja wrote: post #63
thehappypm wrote: post #55

Earlier quoted context omitted.

The covid mRNA vaccines were wildly effective at the original covid strain—95%. But respiratory viruses mutate like crazy.

[flagged]

We've banned this account for repeatedly and egregiously breaking HN's guidelines.

Please don't create accounts to break HN's rules with. It will eventually get your main account banned as well.

https://news.ycombinator.com/newsguidelines.html

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#98

Post by 3q34D5b7pR5H8k6 »

CyberDildonics wrote: post #95
3q34D5b7pR5H8k6 wrote: post #89

Earlier quoted context omitted.

[flagged]

You linked a 4 hour video without even giving specific times. You wouldn't accept that as evidence if someone told you it contradicted everything you said, so why would you expect people to accept that as evidence of things like "rewriting people's genome" or "causing turbo cancer" ?

[dead]

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#99

Post by lamontcg »

amluto wrote: post #11

> Why are mRNA vaccines the future? This may well be true, but I’ll be far more likely to believe it when there’s an mRNA vaccine that’s anywhere near as effective as the best old boring vaccines. (I admit that my personal favorite, not-mRNA, HSV vaccine candidate is from a company, X-vax, that appears to have forgotten to renew its domain.) I’m also not entirely clear about the path by which mRNA technology might el…

> This may well be true, but I’ll be far more likely to believe it when there’s an mRNA vaccine that’s anywhere near as effective as the best old boring vaccines.

You mean like the influenza vaccine that is only about 50% effective and you have to get a shot every year because the virus eventually achieves immune escape? You mean like the old boring human coronavirus vaccines against things like HCoV-229E or HCoV-OC43... that just don't exist?

If you're thinking of something like measles where the vaccine confers lifelong protection, that has nothing to do with the vaccine. The virus just can't mutate to escape the immune system response to it without negatively affecting replication and transmission.

And you can see that with the immune effects of the virus itself. Get actually infected with measles and recover and you'll be protected for life against getting measles again. Get influenza and you won't have lifelong protection. Get COVID or any other human coronavirus and you won't have lifelong protection. Go get into an argument with your own T-Cells about they're so shit against respiratory viruses, they're the ones at fault.

Although with mRNA vaccines we actually might be able to generate vaccines that target more conserved sequences the stalk of influenza's hemagglutinin surface protein and get the immune system to recognize a much broader spectrum of influenza viruses and possibly give lifelong protection. You'll never get that with inactivated or attenuated virus vaccines since you can't target that specifically.

Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less

#100

Post by lamontcg »

amluto wrote: post #59
thehappypm wrote: post #55

Earlier quoted context omitted.

The covid mRNA vaccines were wildly effective at the original covid strain—95%. But respiratory viruses mutate like crazy.

They were wildly effective for a few months after being given. We don’t know how well they would continue to work in the absence of mutation. But it’s worse than that: the revised vaccines appear to be nowhere near as effective even against strains closely related to those which they target. As a somewhat plausible mechanism, repeated doses have been shown to induce IgG4 production, which non-mRNA vaccines don’t seem…

> Measles and Chickenpox are both airborne, although they’re not respiratory the way Covid is. But their respective vaccines are vastly more effective.

Natural infection with Measles and Chickenpox are also vastly more effective at preventing reinfection than natural infection with SARS-CoV-2. It is a property of the virus, not the vaccine.

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