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Researchers discover physical cause of long Covid tiredness

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Re: Researchers discover physical cause of long Covid tiredness

#91
post #19

Am I supposed to believe that these physiological effects have nothing to do with fear of the virus? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447278/

If it's psychosomatic then why does it only happen with this specific virus and not, say, with chronic illnesses?

It’s not psychosomatic, but there usually are multiple contributing factors to serious respiratory disease, and I think it’s OK to consider it as a relevant one of them in many cases.

Fair enough?

Re: Researchers discover physical cause of long Covid tiredness

#92
post #27
post #17

Earlier quoted context omitted.

One mechanism is physiological stress when people believe they’ve been cursed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447278/

So that would affect people who are anti-vaccination (believe it's a curse) and got it anyway? I think there's far more reports of the 'long covid' symptoms than there are people in that camp.

That camp has the people who had a bad reaction to the vaccine or booster, mostly. Not sure how they compare numbers wise.

Maybe the vaccine caused a similar hit to the immune system for some people, this stuff is complicated.

Re: Researchers discover physical cause of long Covid tiredness

#93
post #89

As with any of this research into long covid, it feels deceptive to me. Where is the clarity and consice exacting standards that we are supposed to be in awe of in the scientific community Why is there no mention of whether or not the test subjects had been vaccinated. How do we know that the vaccine did not cause the same symptoms? Surely, only then, could we, I mean I, put this thinking to bed and move on. For bala…

Your comment seems a bit cynical or agenda based, but there are already many groups looking into this. i.e.

https://www.medrxiv.org/content/10.1101/2023.11.09.23298266v...

It isn't these researchers job to distinguish every phenotype of long covid as there are other groups trying to figure that out. When those definitions are clearer, I'm sure more upcoming literature will distinguish that. But for now, the current definition are symptom/observational based as we have no biomarker or means to distinguish post-vaccination / infection based long covid yet.

Re: Researchers discover physical cause of long Covid tiredness

#94

> we saw that the mitochondria of the muscle, also known as the energy factories of the cell *Ahem*, powerhouse of the cell Jokes aside, this is a terrifying stat: "Although the majority of people infected with the SARS-CoV-2 virus recover within weeks...around one in eight will get long-COVID. Symptoms in patients with long-COVID...include severe cognitive problems (brain fog), fatigue, exercise intolerance, autonom…

There is nothing to be “terrified” about. You are conflating different types of “long covid”. Some covid infections, just like the cold or the flu, cause symptoms longer than the 5-7 days, maybe for 2-3 weeks. That’s long covid. Also remember that long covid symptoms include symptoms like depression and it ends up not being very rigorously defined. Then there is the version that creates long term chronic fatigue symp…

Under some developing models by long covid researchers, they believe that with enough of a "viral load" of persistence in your body(or different areas of your body), it can be the difference of being asymptomatic and symptomatic.

Might be worth looking at https://www.cdc.gov/mmwr/volumes/72/wr/mm7232a3.htm which is more aligned to what this study researched.

Re: Researchers discover physical cause of long Covid tiredness

#95
I'm sorry HN, but you continue to downplay long covid when there is evidence like this for a biological pathology right in front of you.

Please stop saying it is psychosomatic. Please stop saying only unfit people get it. People stop saying it is caused only by the vaccine.

All of these things do nothing helpful. The science will continue to push through these opinions regardless.

Why can't the discussion be focused on the actual finding here which is that we have a much clearer model of what is causing PEM / exercise intolerance in symptomatic long covid patients versus asymptomatic controls via amyloid deposits, mitochondria dysfunction, and muscle structure changes.

Re: Researchers discover physical cause of long Covid tiredness

#96

Earlier quoted context omitted.

There is nothing to be “terrified” about. You are conflating different types of “long covid”. Some covid infections, just like the cold or the flu, cause symptoms longer than the 5-7 days, maybe for 2-3 weeks. That’s long covid. Also remember that long covid symptoms include symptoms like depression and it ends up not being very rigorously defined. Then there is the version that creates long term chronic fatigue symp…

What is the fitness level of people suffering from the more extreme cases of "long covid"? As in, are they overweight and unhealthy in other ways? Because if that is the case the issue isn't the virus, it's the general health of that population in the first place. That's my gripe about this discussion, because I can never tell, since all I get is anecdotes, if this is a result that's agnostic to body type/fitness. Do…

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128...

Re: Researchers discover physical cause of long Covid tiredness

#97

> we saw that the mitochondria of the muscle, also known as the energy factories of the cell *Ahem*, powerhouse of the cell Jokes aside, this is a terrifying stat: "Although the majority of people infected with the SARS-CoV-2 virus recover within weeks...around one in eight will get long-COVID. Symptoms in patients with long-COVID...include severe cognitive problems (brain fog), fatigue, exercise intolerance, autonom…

There is nothing to be “terrified” about. You are conflating different types of “long covid”. Some covid infections, just like the cold or the flu, cause symptoms longer than the 5-7 days, maybe for 2-3 weeks. That’s long covid. Also remember that long covid symptoms include symptoms like depression and it ends up not being very rigorously defined. Then there is the version that creates long term chronic fatigue symp…

> That is a much smaller percentage of the population, more like 1% or less.

(French) https://www.sante.fr/covid-long-2-millions-de-personnes-pres...

1.2% of the French population has long COVID with large/very large impact on daily activities. 4% has long COVID more generally. So I expect more than 1% of chances of getting debilitating symptoms. Though it could be that people with "light" long COVID recover while people with debilitating long COVID don't and make for an unexpectedly high share of the population as they accumulate. (not saying I think that this is the case, just saying this is a possible alternative explanation to "chances of debilitating long COVID are chances of long COVID / 4")

Re: Researchers discover physical cause of long Covid tiredness

#98
post #89

As with any of this research into long covid, it feels deceptive to me. Where is the clarity and consice exacting standards that we are supposed to be in awe of in the scientific community Why is there no mention of whether or not the test subjects had been vaccinated. How do we know that the vaccine did not cause the same symptoms? Surely, only then, could we, I mean I, put this thinking to bed and move on. For bala…

> How do we know that the vaccine did not cause the same symptoms?

Because they started after COVID and not vaccination?

Edit: will add https://www.scientificamerican.com/article/vaccination-drama...

Vaccination actually reduces the risk.

Re: Researchers discover physical cause of long Covid tiredness

#99
post #84

An interesting fact: this research was paid for by crowd funding because the Ministry of Health refused to fund it. The Netherlands is also unique in Europe as the only country which does not even try to treat this condition. If you get ME/CFS you are, quite literally, left to die here. Unless someone in your network looks after you.

Has anybody died from ME/CFS?

There are regular stories in the paper about people suffering from ME/CFS choosing to end their own lives. They're usually really young (20s).

So yes.

Re: Researchers discover physical cause of long Covid tiredness

#100

[flagged]

You realize that there was no vaccine for about a year, during which millions of people were infected, many dying and many more left with long COVID symptoms. There is no need to scapegoat vaccines for causing these problems.

There isn't any interest in this control group?
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