Live data from Hacker News

Nicotine (2016)

gwern.net

91–100 of 273 posts

Re: Nicotine (2016)

#91

Earlier quoted context omitted.

You really should have kept reading because this is addressed

And dismissed over and over again. The author is playing with cyanide and doesn’t even understand that.

Tobacco is addictive, nicotine alone without MAOIs is not nearly as addictive.

Re: Nicotine (2016)

#92
post #60
post #9

Earlier quoted context omitted.

Isn't caffeine a vasoconstrictor as well? Wouldn't that make coffee a silent killer?

I don't get how so many people like coffee. I've tried it maybe a handful of times in my life, getting the type that my friends said is great, and I've always found it to be reminiscent of dirty water, that is, water that has been contaminated with dirt. Why do so many people like it? My friends say they like the taste, but I don't believe them. I think it has to do with them being coerced into liking coffee at a you…

[deleted]

Re: Nicotine (2016)

#93
author shrugged this off pretty easily but nicotine is a vasoconstrictor which is an issue when combined with it being addictive. that's a problem if you ever have certain types surgery due to wound healing and lack of blood flow. There's more than a few people that effed their plastic surgery results because they immediately went back to nicotine. (note: not all plastics are necessarily volunteer, such as after certain cancer/tumor/melanoma removals).

Re: Nicotine (2016)

#94

I was always fascinated by cigarettes and stole one when I was 10 and that was where my journey of addition to nicotine began. I now vape everyday and chew 2mg of gum if I’m on a plane or some other situation. I’ve tried to quit multiple times but I’m weak. I can go a few months but always get pulled back. IMO there are no benefits. If you never had nicotine and this link made you curious don’t. You will most likely…

Why do you get pulled back if there are no benefits?

Re: Nicotine (2016)

#95

Earlier quoted context omitted.

Nicotine not addictive? That’s a bold claim.

ΔFosB expression is lower from nicotine than it is caffeine.

I'm not familiar with the biochemistry involved or what exactly "ΔFosB expression" means, and I don't know if the term "addiction" is used in its strictly technical definition here (i.e activating the reward circuit) or if it's used to generally mean some form of dependence...

but it's worth noting that caffeine dependence is pretty common.

Re: Nicotine (2016)

#96
post #32

After being on IRC for the best part of two decades (and the fringe groups who frequent the medium) I have seen the word “nootropics” banded about. The first time, I thought it was a fun idea but nothing I wanted, see; my brain is all I have so I dont much fancy experimenting with it- this is also why I avoided alcohol and coffee despite social pressures. The community that formed went away as quickly as it had been…

> Nicotine itself is addictive mostly because it has such a long half life, it stays in the body for multiple weeks.

It has a half-life of 2 hours [0]. If it lasted longer I think its withdrawal effect would be less steep and more gradual.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794006/

Re: Nicotine (2016)

#97
post #31

Earlier quoted context omitted.

Like… people do get addicted to caffeine right? I know people who drink a very large amount of coffee, who “can’t function” without it, and who generally seem to be in a pretty bad shape. The behavior of a certain segment of the population with regard to coffee looks a hell of a lot like the stereotypical addictions to drugs, including just ending up in bad shape. Totally anecdotal of course but “caffeine in large am…

Caffeine physiological addiction is very light. Withdrawal symptoms last about 2 days and are mild. > including just ending up in bad shape Not sure what you mean by that, I'm not aware of people ending up on the streets because of caffeine.

[deleted]

Re: Nicotine (2016)

#98

I was always fascinated by cigarettes and stole one when I was 10 and that was where my journey of addition to nicotine began. I now vape everyday and chew 2mg of gum if I’m on a plane or some other situation. I’ve tried to quit multiple times but I’m weak. I can go a few months but always get pulled back. IMO there are no benefits. If you never had nicotine and this link made you curious don’t. You will most likely…

Why do you get pulled back if there are no benefits?

As I said I’m weak.

Edit: the only benefit I get now is not thinking about nicotine until my cravings kick in again. While loop from hell.

Re: Nicotine (2016)

#100
post #32

After being on IRC for the best part of two decades (and the fringe groups who frequent the medium) I have seen the word “nootropics” banded about. The first time, I thought it was a fun idea but nothing I wanted, see; my brain is all I have so I dont much fancy experimenting with it- this is also why I avoided alcohol and coffee despite social pressures. The community that formed went away as quickly as it had been…

I’ve seen a similar story.

Problems that could be solved by exercise, sunlight, sleep, and a positive mental attitude, but then they try nootropics instead.

It always ends the same way - psychosis, incoherence, paranoia.

The brain is a finely tuned network, use it’s built-in hapiness generators rather than throwing sledgehammers at it.

Post reply on HN