FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management • Hacker News Board

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#91

Post by jwestbury » Fri, Nov 10, 2023, 8:32 AM UTC

nathanyz wrote: post #16

xnx wrote: post #12

This is definitely a historic moment in US public health. Today we look at photos and marvel at how prevalent smoking was 50 years ago (in restaurants, in hospitals, in airplanes, etc.). 40 years from now people will look at photos from the last decade and be in disbelief at how widespread obesity was.

This cannot be understated. Obesity is being changed from a willpower problem to a chronic disease that is treatable. The follow-on effects of this are huge.

Should be noted: Basically nothing is a "willpower" problem, in reality. Psychological research is fairly clear on this: People who make good decisions are people who don't even consider the bad decisions, not people who have some higher level of "willpower."

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#92

Post by Obscurity4340 » Fri, Nov 10, 2023, 6:37 PM UTC

bb88 wrote: post #89

petesergeant wrote: post #84

Earlier quoted context omitted.

The problem isn't prescription in the US, the problem is whether or not someone's insurance will cover weight-loss medications as they're expensive. If you have the cash, Mounjaro was easily available to you in the US already for weight-loss, and finding a doctor to prescribe it wasn't (much of) a problem. The various subreddits concerned with this certainly talk about whether or not insurance should be legally compe…

And that's what's available today. Lilly has the so-called "Triple-G" shot in trials right now. Retartrutide shows even better weight loss potential than Tirzepatide

To what extent do you think this addresses root causes? Like, does it physiologically compel them to be less hungry or what?

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#93

Post by petesergeant » Sat, Nov 11, 2023, 5:55 AM UTC

Obscurity4340 wrote: post #92

bb88 wrote: post #89

Earlier quoted context omitted.

And that's what's available today. Lilly has the so-called "Triple-G" shot in trials right now. Retartrutide shows even better weight loss potential than Tirzepatide

To what extent do you think this addresses root causes? Like, does it physiologically compel them to be less hungry or what?

Yes, that’s exactly what it does. My hunger is absolutely diminished, and my reward feedback from eating are also diminished.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#94

Post by Obscurity4340 » Sat, Nov 11, 2023, 2:54 PM UTC

petesergeant wrote: post #93

Obscurity4340 wrote: post #92

Earlier quoted context omitted.

To what extent do you think this addresses root causes? Like, does it physiologically compel them to be less hungry or what?

Yes, that’s exactly what it does. My hunger is absolutely diminished, and my reward feedback from eating are also diminished.

Is developing tolerance/dose escalation a prescient issue here?

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#95

Post by petesergeant » Sat, Nov 11, 2023, 5:29 PM UTC

Obscurity4340 wrote: post #94

petesergeant wrote: post #93

Earlier quoted context omitted.

Yes, that’s exactly what it does. My hunger is absolutely diminished, and my reward feedback from eating are also diminished.

Is developing tolerance/dose escalation a prescient issue here?

People move through the different doses at different speeds, and most people seem to find a stopping, long-term dose, but also there are people complaining that they’ve hit 15 and it’s starting to wear off. There’s also not a well-developed stopping protocol, other than “this is a drug for life but maybe start spreading out dosage”.