I know framework is a popular company on tech forums but it's always felt like a solution in search of a problem. Laptops I own that only have a CPU are rarely computationally bounded in what I'm trying to do, by the time the CPU is showing its age the battery and case are usually showing their age too. But lets say I need the most up to date CPU and can't wait, why would I now need a desktop computer with no expanda…
There is the chipset problem with desktops, if you are wanting a feature of a newer cpu, you might need to replace the motherboard again even if the sockets match.
I don't really hear about people upgrading just their CPU, its always either more ram or more video : so to consider the cpu and motherboard as one unit, I do not think it is different than how build-your-own desktop computers are now.
(also noting that you can change the ram and add a videocard to current framework laptops).
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Enthusiasts are somewhat a focus for frmaework consumption at the moment, in turn, pet projects are probably going to be the focus. Emulation-centric consoles, home servers, etc, are probably going to be a signifigant portion of old mobos
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framework 16 has a dedicated video/expansion bay