Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Time-restricted eating reshapes gene expression throughout the body

sciencedaily.com

Post reply on HN
Print view View original

91–97 of 97 posts

Re: Time-restricted eating reshapes gene expression throughout the body

#91

Post by geraldwhen »

piqi wrote: post #37
snozolli wrote: post #28

Earlier quoted context omitted.

In my experience, it's exceptional in America. This may be due to constant indoctrination that "breakfast is the most important meal of the day". Also, modern food processing has put all sorts of late-night snacks at our fingertips.

Hard to imagine skipping breakfast, lunch, coffee/tea w/milk & cream, and all snacking during the day, everyday is normal outside America. Isn't burned bread with beans or butter for breakfast a thing in the UK? 16:8 means if your last calories are before 10PM, you wouldn't eat anything at all until after 2 PM. And this would be every day, not every other day. 12:12 might be more common, but not consistently.

In America, I find that anyone “snacking” is overweight or obese.

There is no need to snack. Meals are plenty enough as is, and as this thread is indicating, maybe even one meal too many.

Re: Time-restricted eating reshapes gene expression throughout the body

#92

Post by notyourday »

manmal wrote: post #36
mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

To give another N=1, I don’t feel good on a 16:8 split. At least not when the eating window starts at noon. Long term (18 months) this zapped my energy and I lost a lot of muscle. Yes, weight loss was phenomenal, but I gained all of that back in the phase of exhaustion that followed. What has worked better for me was longer fasts, eg 48h, max once per week. And lately I‘ve been experimenting with skipping late dinner…

> Long term (18 months) this zapped my energy and I lost a lot of muscle. Yes, weight loss was phenomenal, but I gained all of that back in the phase of exhaustion that followed.

Muscle loss is an adaptation to loss of load on the muscle. Internet trope of "you lose muscle when you lose fat" is just that - a trope. If you were 100lb heavier, your muscles were loaded with extra 100lb. Should you lose the 100lbs, if you do not engage in the appropriate resistance exercises to provide equivalent of additional 100lb load, your muscle mass will decrease

Re: Time-restricted eating reshapes gene expression throughout the body

#93

Post by red-iron-pine »

piqi wrote: post #27
pammf wrote: post #14

I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…

> ...got tired of debating whether it was healthy or not... I've had a similar experience. "unhealthy" seems to often be used in place of "not normal." I don't blame them. Advertising has been pushing "normal" food choices for 100+ years. Social gatherings are focused too much on eating. People are shamed for being "skin and bones." I've been doing it for more than 10 years. I never get hunger pangs. I don't feel the…

> People are shamed for being "skin and bones."

In all of western and handful of middle eastern countries I've lived in, I've never once seen people say that except in jest; e.g. imitating the Concerned Italian Mother or Babushka, etc.

With the exception of 2-3 very skinny coder-types, pretty much everyone I met could have lost 3kg and still looked fine, and most of them (myself included) could probably stand to lose 5kg or more. Pretty much everyone I met in Dubai and the US was fat as fuck; little more reasonable in Canada, Australia, and France. Asia was still pretty lean, but getting bigger.

Re: Time-restricted eating reshapes gene expression throughout the body

#94

Post by PcChip »

otoburb wrote: post #66
kbrisso wrote: post #34

Earlier quoted context omitted.

You need to stay on it for months to become keto adapted. I would say 6 months minimum, after that the energy swings go away and you generally have a lot more energy. You can also add MCT oil. The problem with keto is eating enough calories.

>> You can also add MCT oil. If you use MCT oil it would be best to start slowly and not on an empty stomach because it can cause stomach aches otherwise.

also note that it eats through some plastics

I found that it dissolves red solo cups

Re: Time-restricted eating reshapes gene expression throughout the body

#95

Post by PcChip »

gavinray wrote: post #40
StefanWestfal wrote: post #32

Earlier quoted context omitted.

I tried it for some time but felt cranky in the morning until I ate at lunch time. How was your experience regarding cravings, hunger and mood changes over time when starting your fasting?

Not the poster but the hunger lessens after the first few weeks as you adapt to it, or at least that's my experience I start to dread eating a bit now because I get tired/sleepy after I do. I want to eat because I'm hungry but mentally feel clearer if I don't.

what if you broke up the meal into several smaller ones, do you think that would prevent you from feeling mentally foggy?

Re: Time-restricted eating reshapes gene expression throughout the body

#96

Post by justinlloyd »

Rury wrote: post #77
mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

I have been doing similar for about 3 years now, with similar results, but one thing that has been problematic with for me... is my bowel movements just don't seem to function well when I'm doing keto. The only thing that seems to fix them is milk+cereal... (fiber from veggies don't seem to quite cut it). So I kind of alternate between periods of keto, and a normal diet. How do you do strict keto?

Very low carb keto is known to stop you up, if that is what you are referring too. I didn't get any issues, but I kept my carbs a little higher than my wife who regularly did have issues. A small glass of salty water fixes it. Don't venture too far from a bathroom after ingesting.

Re: Time-restricted eating reshapes gene expression throughout the body

#97

Post by justinlloyd »

mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

N = 1. 18:6 for me. 2PM to 8PM, with occasional falling off the wagon due to social obligations or just simply forgetting to eat and then realizing I need to eat. I have noticed if I eat sugary snacks with my last meal that I get ravenously hungry much earlier the next day. There are some days where I unintentionally forget to eat until 4PM or so.

I tried 16:8 but it never seemed to have any effect on weight loss for the 2PM to 10PM range. And my weight would creep up with that regimen. I suspect that might be related to late night hormonal changes in the human body preventing the digestion of certain types of food. I should try a 16:8 with 12PM to 8PM at some point and track the results.

Post reply on HN