Or just make fentanyl very hard to prescribe? We are getting dumber by the minute.
most fentanyl is manufactured in clandestine labs in mexico and distributed by drug gangs
Fentanyl vaccine tested in rats
91–100 of 378 posts
Re: Fentanyl vaccine tested in rats
#92Nothing wrong with this being on the front page. Just posting this here as a question. Is the reason why this is on the front page because a good number of software engineers addicted? Maybe you don't have the numbers but you yourself who's reading this may be personally interested in a vaccine?
Not me personally, but I distanced myself from some close college friends when I figured out they were using heroin. Both later cleaned up, one relapsed, and I bumped into the other at the funeral.
So, yeah, the opiate problem effects more than just users.
Re: Fentanyl vaccine tested in rats
#93This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? Problems either way; if just fentanyl, then, duh, that's not the only way to get high. If all opioids... So it makes opioids no longer available for pain relief... forever? ("vaccine"?). (Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain). It claims to block the ability to get…
This is an incredible opportunity to save lives. You need to familiarize yourself with accidental opioid overdose deaths. Most people who die from a fentanyl overdose were not intending to ingest fentanyl. Fentanyl is often used to boost the strength of more expensive opioids sold on the street. Fentanyl is very cheap to produce compared to heroin or whatever is the flavor of the month pressed pill. People die because the recreational dose for an opioid like heroin isn't many orders of magnitude away from the LD50
Re: Fentanyl vaccine tested in rats
#94This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? Problems either way; if just fentanyl, then, duh, that's not the only way to get high. If all opioids... So it makes opioids no longer available for pain relief... forever? ("vaccine"?). (Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain). It claims to block the ability to get…
> “The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile.
Not really clear if it prevents ODing but the article says:
> Our vaccine is able to generate anti-fentanyl antibodies that bind to the consumed fentanyl and prevent it from entering the brain, allowing it to be eliminated out of the body via the kidneys.
Re: Fentanyl vaccine tested in rats
#95Nothing wrong with this being on the front page. Just posting this here as a question. Is the reason why this is on the front page because a good number of software engineers addicted? Maybe you don't have the numbers but you yourself who's reading this may be personally interested in a vaccine?
I think it’s more about interest in the system, threat and the mitigation. The technical nature of biochemistry attracts many to this forum. Biohackers if you will.
Additionally I think a lot of hacker types are just interested in drugs and drug policy. There are lots of back and forths on here about "legalize all drugs" and stuff like that. There's a lot of hacker-related threads running through drug topics - there's the whole "hacking your mind" / psychonaut angle, there's the sorta libertarian intersection with the law, there's the counter-culture ideas and historical interest.
Even as a kinda drug-interested guy though, I've always thought of opioids as strictly off limits recreationally, just too many downsides and they don't have the same "expand your mind" appeal as psychedelics or even weed. (Not really endorsing the idea of mind expansion, I think it's oversold, but it's part of the culture).
Re: Fentanyl vaccine tested in rats
#96Oh boy, the pharmaceutical companies can sell a new product to help solve the mess that one of their previous products created. An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place. It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. The "but people are in pain…
I would suggest becoming actually educated before developing strong opinions.
The drug is extremely useful and saves lives in a clinical setting; chances are it will save your life or someone you know and love. It's literally used _every hour_ around the clock in ERs.
Nearly all problematic Fentanyl in the US is illegally imported and created by third parties overseas. It is not manufactured by those big bad US Pharma companies.
Re: Fentanyl vaccine tested in rats
#97Oh boy, the pharmaceutical companies can sell a new product to help solve the mess that one of their previous products created. An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place. It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. The "but people are in pain…
its not only that, the vaccine will create issues for people when they want to have a surgery so it CREATES NEW ISSUES
While fentanyl is amazingly effective in a controlled environment like an operating room, it's not the only option at their disposal. I suppose if this vaccine took off and you got it, it'd be good to keep an electronic medical ID on you.
Re: Fentanyl vaccine tested in rats
#98This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? Problems either way; if just fentanyl, then, duh, that's not the only way to get high. If all opioids... So it makes opioids no longer available for pain relief... forever? ("vaccine"?). (Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain). It claims to block the ability to get…
> Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain
I had rather major surgery. Once I was sent home, the opioids just weren't worth it. (I was surprised.) Ibuprofen actually worked a lot better.
Granted, I don't think I'd want to undergo surgery without opioids during the first few days of recovery.
Re: Fentanyl vaccine tested in rats
#99This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids? Problems either way; if just fentanyl, then, duh, that's not the only way to get high. If all opioids... So it makes opioids no longer available for pain relief... forever? ("vaccine"?). (Major surgery and recovery without opioids is no walk in the park, it's PTSD-inducing excruciating pain). It claims to block the ability to get…
>This is kind of strange. Is it really fentanyl-specific, or does it effect all opioids?
This is answered in the article.
>“The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile.
>Problems either way; if just fentanyl, then, duh, that's not the only way to get high.
Yes, but fentanyl is considerably more dangerous than most of those other methods. Mis-judging your poorly-cut heroin dose by a milligram at least doesn't kill you. That's part of the point of targeting fentanyl itself with a vaccine - it would be accepted by the drug-taking public, because most of them don't want to be taking fentanyl in the first place: there are other ways to get high.
Re: Fentanyl vaccine tested in rats
#100Earlier quoted context omitted.
A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.
Let's go another way with this: You are extremely unlikely to ever come across a fentanyl user, even if you work for law enforcement, even if you're a LEO in a major metro. 10x people died of heart attacks than any opioid, not only fentenyl, over the past few years. Almost as many people died of cancer as heart attacks, and half as many people died of COVID as cancer. Obviously, you can't equate research with other r…
> You are extremely unlikely to ever come across a fentanyl user, even if you work for law enforcement, even if you're a LEO in a major metro.
is this a joke?