Nuclear power is expensive in no small part because of the safeguards needed to try to avert catastrophic accidents. Humans are fallible, and our best intentions can be subverted by inadequate training; fatigue; inattention; laziness; or what we used to call "a loss-of-brain accident." As a result, we can f[oul] up at any stage of design, construction, operation, or maintenance of a nuclear reactor. (Neither Three Mi…
Strong safeguards are also needed in iron smelters and steel foundries, in ammonia synthesis, and in making aluminum. In the mining of coal and extraction of oil and natural gas. Yet all these materials are cheap.
The LD50 for strontium 90 in hamsters (90 day survival) is 2 millicuries per kilogram: http://www.rrjournal.org/doi/abs/10.2307/3573895
Given strontium 90's specific activity of 142 curies/gram (https://ntrs.nasa.gov/citations/19680020487), in mass terms that's 14 micrograms/kg for the LD50. Gram for gram, strontium 90 is about 1000 times as acutely deadly as arsenic, or 3 times as deadly as the chemical warfare agent sarin. A commercial power reactor of 1000 MWe output can have an inventory of tens of kilograms of strontium 90 in the core [1] along with even more acutely dangerous shorter-lived fission products.
Nuclear reactors are safe because of careful defense-in-depth in their engineering and operation. They need deeper, more stringent safety systems than steel plants or ammonia plants because they contain substances much more toxic than those found in steel plants or ammonia plants. You also see extreme safety practices in facilities that handle non-radioactive poisons, if the poisons are potent enough:
"Inside Fort Botox"
https://www.bloomberg.com/news/features/2017-10-26/inside-fo...
[1] https://www.osti.gov/servlets/purl/6822946 See table 2.2 "Fission product inventories"