> "The Human Genome Project finally released a complete human genome sequence in 2003, in a project that took 13 years to complete."
The most remarkable thing about that accomplishment was how little it resulted in. Almost all of the hopes about medical breakthroughs and finally gaining a complete understanding of human biology have not been realized. There are many reasons for this - for example, the genome edits itself as it develops in different cell types, so the genome of your nerve cells is not the genome of your immune cells, heart cells, liver cells etc. Communication between all these cell types is incredibly important and that's hard to get from the genomic sequence. It turns out the 3D structure of the genome is as important as the 3D structure of proteins is, as it is an active dynamic entity in all cell types. There are probably dozens of other reasons on top of those.
As far as the notion of uploading one's consciousness into an artificial substrate while retaining one's sense of self, that seems highly implausible when we don't really understand the basic physical mechanism of consciousness, other than a vague idea that the brain is the most important component (even though nerves saturate the entire body).
Hence the whole subject remains in the science fiction arena and will stay there for a good long while, perhaps a century or more.