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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#91

Post by gniv »

mbreese wrote: post #16
astrange wrote: post #6

This article is a bit old (like the other comment about missing year tag says). I think there's newer news that AKG, an easy to get and cheap supplement, has anti-aging effects with no known issues. https://www.science.org/content/article/bodybuilding-supplem...

The actual paper is here [1]. And it’s not quite as conclusive in mammals yet. But it sounds like there is a clinical trial to actually study the supplement, which is a welcome thing in the anti-aging world. I’m happy to read that this work came out of the Buck Institute in Novato, which is a solid research institution. It’s also a beautiful campus. Disclaimer: I was there for a short stint as a postdoc a while back…

That articles says "Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging."

But there is no citation for this statement. Any idea where to read about how these levels change naturally?

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#92

Post by aaaaaaaaaaab »

jamesblonde wrote: post #38

Epigenetics is fascinating. I just came back from a project meeting, where i work with people who discovered that HRT (hormone replacement therapy) slows down epithelial cell aging. Epithelial cells are the cells that cover all your vital organs, so they are important for aging. Now, there are even commercial companies that measure Epigenetic age of cells with a technique called DNA methylation. References: https://i…

Time to hit up my gymrat brother for some testosterone I guess!

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#93

Post by bowsamic »

bawolff wrote: post #90
bowsamic wrote: post #82

Earlier quoted context omitted.

I’m talking about the physical life, not the spiritual one

Sounds like a distinction without a difference to me.

Why? They seem quite distinct to me

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#96

Post by xiphias2 »

krageon wrote: post #85
xiphias2 wrote: post #83

Earlier quoted context omitted.

Are you really comparing Theranos to the Nobel prize winning Dr Yamanaka, and the amazing group of scientists who have put their lives to work on cellular reprogramming? Of course it's more than just about money, it looks like it's the more efficient path, but there's a huge need in research to stop cells from losing their identity during partial reprogramming (and cause cancer).

> Are you really comparing Theranos to the Nobel prize winning Dr Yamanaka [...] I was responding directly to what you said, this is a strawman. > Of course it's more than just about money [...] This is not the impression I got from your post, because all you talked about was money.

I think both approaches are amazing advancement for humanity, and I wish Greg Fahy would get more funding as well.

Before Jeff Bezos came in, the money was really really missing from the longevity field that I have been following for the last 10 years since I've got a serious rare, but not deadly cronic illness.

Maybe I've got a bit sad when you refered money as not the most important thing, because Gregory Fahy said during an interview that they had to stop the experiments because of lack of funding. They needed a few million dollars to run the experiments, which is nothing compared to the value they can provide compared to rejuvenating people. I was thinking of investing personally, but I'm too small to be an investor myself.

Altos Labs being created is a huge deal, because when the technology works (and at this point there's no reason why it wouldn't), it can save the lives of literally billions of people. Maybe it's hard to see through my comments, but I truly care, and I'm hopeful that both of us (you and me) will be able to use it.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#97

Post by moonchrome »

aaaaaaaaaaab wrote: post #92
jamesblonde wrote: post #38

Epigenetics is fascinating. I just came back from a project meeting, where i work with people who discovered that HRT (hormone replacement therapy) slows down epithelial cell aging. Epithelial cells are the cells that cover all your vital organs, so they are important for aging. Now, there are even commercial companies that measure Epigenetic age of cells with a technique called DNA methylation. References: https://i…

Time to hit up my gymrat brother for some testosterone I guess!

Not sure riding high on dirty test (dosing TRT levels off toilet test going around gyms will be next to impossible) will slow down ageing - but it will probably make you juicy. Make sure to hit the gym to double the gainz.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#98

Post by mrnotcrazy »

So if I am understanding this right, this is turning back the epigenetic clock but not rejuvenating the individual? So it could help prevent aging but not reverse.

As we age does our body act differently to make life easier as we get older? If so could this make life worse?

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#99

Post by beanjuice »

mtw wrote: post #94

Did they continue tracking health effects years after they study ? It’s possible the drugs reversed the body clock but will accelerate it after. Much like coffee gives you a temporary boost, then makes you crash later

By what basis do you make this estimation? The factors for aging and feeling awake arent exactly comparable.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#100

Post by pseingatl »

narrator wrote: post #3

You can do this at home, except for the little inconvenience that growth hormone is a scheduled drug. I wonder what the results would be with just growth hormone. Let's ask Sylvester Stallone[1] who looks great for 75 and got caught trying to get into Australia with illicit Growth Hormone a while ago[2]. [1] https://en.wikipedia.org/wiki/Sylvester_Stallone [2] https://abcnews.go.com/Health/ActiveAging/story?id=317601…

It has to be refrigerated, which makes travel difficult. Not to mention the hypodermics needed for intramuscular injections.
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