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Vitamin D and Depression (2020)

ncbi.nlm.nih.gov

91–100 of 221 posts

Re: Vitamin D and Depression (2020)

#91

I live pretty far north. For months at a time here there is basically no sunlight. Sometimes people try to sell you artificial light of one kind or another. Do they work?

Some UV lamps have been shown to help the body make Vitamin D. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846322/

I would recommend checking to see if you're actually getting low Vitamin D level during the winter and talk to a doctor to get their opinion on best treatment.

Re: Vitamin D and Depression (2020)

#92

Daily morning and afternoon exposure to bright light might actually be more important to reducing depression than direct vitamin D supplementation. Low vitamin D might just be an indicator that you are not getting enough sunlight. Sunlight also affects melatonin and serotonin levels, and synchronizes your Circadian rhythm. Not sure why that article doesn't talk about Seasonal affective disorder (SAD), and how bright…

Sunlight’s effects on body chemistry also have a damping effect on inflammation. It’s a funny thing. Sunlight has an impact on many chemical processes in and on the body. One example: Our skin is coated with a bunch of chemicals. There’s a number of different acidic chemicals. These are known as the “acid mantle”: https://en.wikipedia.org/wiki/Acid_mantle One of these substances is urocanic acid . The body manufactur…

Sunlight exposure also stimulates nitric oxide production, which is important for circulatory system health.

Re: Vitamin D and Depression (2020)

#93
post #81

Earlier quoted context omitted.

5k IUs is well beyond anything your body has a use for, and in fact is above what your body can tolerate! [0] > RDA: The Recommended Dietary Allowance for adults 19 years and older is 600 IU daily for men and women, and for adults >70 years it is 800 IU daily. > UL: The Tolerable Upper Intake Level is the maximum daily intake unlikely to cause harmful effects on health. The UL for vitamin D for adults and children ag…

Highly doubt 5k IUs is the issue. Some select quotes from "Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective" by Michael Holick in Mayo Clinic Proceedings [0]: > Ekwaru et al recently reported on more than 17,000 healthy adult volunteers participating in a preventative health program and taking varying doses of vitamin D up to 20,000 IU/d. These patients did not demonstrate any…

[0] is an editorial and [1] seemingly went unpublished, other than in PLOS One, which means it goes through a very different peer review process than most other journals (that is, no peer review on its content, only on its methodology).

Re: Vitamin D and Depression (2020)

#94

Daily morning and afternoon exposure to bright light might actually be more important to reducing depression than direct vitamin D supplementation. Low vitamin D might just be an indicator that you are not getting enough sunlight. Sunlight also affects melatonin and serotonin levels, and synchronizes your Circadian rhythm. Not sure why that article doesn't talk about Seasonal affective disorder (SAD), and how bright…

Sunlight’s effects on body chemistry also have a damping effect on inflammation. It’s a funny thing. Sunlight has an impact on many chemical processes in and on the body. One example: Our skin is coated with a bunch of chemicals. There’s a number of different acidic chemicals. These are known as the “acid mantle”: https://en.wikipedia.org/wiki/Acid_mantle One of these substances is urocanic acid . The body manufactur…

Thank you for this fascinating comment! I can't wait to read through all of your links.

Re: Vitamin D and Depression (2020)

#95

Interestingly the fix to my seasonal affective disorder was a move a couple years ago into an apartment with no blinds and tons of sun in the morning (our previous place had black out blinds). We never got to adding blinds, and we have no intention to at this point—I wake up with sunrise naturally nowadays around 6am and haven’t had SAD since. I’m of the impression that black out blinds are generally poor for sleep h…

Depends, they can hide streetlight too which can be disturbing sleep pretty intensely...

Re: Vitamin D and Depression (2020)

#96

My first winter in NYC was very rough and I didn't understand why at first. I got a blood test at the doc and he said my vitamin D was very low. I committed to walking in the sun at least a half hour a day, weather permitting, and I never really had issues again. Part of the issue was I was spending a lot of time walking outside but not in sunlight due to the tall buildings. Just my anecdotal 2c

I live in Seattle and have been depressed for a while. I had my Vitamin D3 levels checked via blood test, and they were really low. Started taking 5,000 IU per day, and I feel exactly the same as before.

To answer a bunch of questions: Yes, I had bloodwork done later showing my D3 level in the typical range. Whether that was due to the supplement, or diet, or lifestyle I can't say. I take 1 pill (USP certified) on average 2-3x per week. So not every day.

I've got treatment resistant depression and have tried probably everything else you're about to suggest. The only thing that kind of helped was dihydrotestosterone, but that is now illegal in the US. Also tianeptine and vorinostat, but also very hard to get in the US these days.

Re: Vitamin D and Depression (2020)

#97

I live pretty far north. For months at a time here there is basically no sunlight. Sometimes people try to sell you artificial light of one kind or another. Do they work?

My understanding is that 10000 lux bulbs are accepted treatment for SAD. I live in a dull country and bought one despite not suffering from SAD. Anecdotally I find it great to help wake up in the dark winter mornings.

Re: Vitamin D and Depression (2020)

#98
post #61

Earlier quoted context omitted.

Anecdata: I grew up in LA. I was always relatively healthy. Moved to NYC. Developed autoimmune disease by my 6th year in NYC. I often wonder if I would have developed the disease if I had stayed in LA.

I think changing location does have a huge effect. Personally when I go to LA or SF (from Texas) I get sick 100% of the time, without fail.

For some reason I was often sick when I lived in Stockholm (Sweden). A friend there mentioned having the same problem.

Re: Vitamin D and Depression (2020)

#99

Earlier quoted context omitted.

> Taking 60,000 international units (IU) a day of vitamin D for several months has been shown to cause toxicity. This level is many times higher than the U.S. Recommended Dietary Allowance (RDA) for most adults of 600 IU of vitamin D a day. [0] I think you may be poisoning yourself. [0] https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-h...

That would certainly be true had I done that from day one as I had mentioned. Their documentation as with most medical documentation is based on the lowest common denominators. They will not risk explaining why one might do what I am doing.

It seems true without qualification.

What you're saying here has a lot in common with "woo", I hope you realize.

Re: Vitamin D and Depression (2020)

#100

Earlier quoted context omitted.

That would certainly be true had I done that from day one as I had mentioned. Their documentation as with most medical documentation is based on the lowest common denominators. They will not risk explaining why one might do what I am doing.

It seems true without qualification. What you're saying here has a lot in common with "woo", I hope you realize.

I suppose time will tell. I've been doing this a number of years. I will check back in a few more years to see how things are going. Honestly the cholecalciferol levels are the least taboo of the biohacking I do with myself. The more risky testing I did was to see how high I could go on the tocotrienols, tocopherols and fibrinolytic enzymes before I ran into bleeding.
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