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Alpha-Gal Syndrome

mayoclinic.org

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Re: Alpha-Gal Syndrome

#91

Post by amluto »

sildur wrote: post #86
setgree wrote: post #77

My dad got Alpha-Gal a few years back and is now severely allergic to beef; recently he ordered the impossible whopper at Burger King and got the same allergic reaction, suggesting either a mix-up or some serious contamination. He was fine but it's no joke, can cause anaphylaxis, etc. Side note, here's a free idea for a book: ecoterrorists conduct underground gain-of-function research on Alpha-Gal, making it transmit…

> Side note, here's a free idea for a book: ecoterrorists conduct underground gain-of-function research on Alpha-Gal, making it transmit from person to person rather than from tick to person I would hack into a covid vaccine factory and modify the mRNA code so it produces the spike protein and the alpha-gal protein.

Alpha-gal is a sugar, so this wouldn’t work directly. Also, the syndrome seems to be IgE-mediated, and the mRNA vaccines are intended to induce IgG and perhaps IgA production. So this might not work.

Re: Alpha-Gal Syndrome

#92

Post by neltnerb »

sildur wrote: post #86
setgree wrote: post #77

My dad got Alpha-Gal a few years back and is now severely allergic to beef; recently he ordered the impossible whopper at Burger King and got the same allergic reaction, suggesting either a mix-up or some serious contamination. He was fine but it's no joke, can cause anaphylaxis, etc. Side note, here's a free idea for a book: ecoterrorists conduct underground gain-of-function research on Alpha-Gal, making it transmit…

> Side note, here's a free idea for a book: ecoterrorists conduct underground gain-of-function research on Alpha-Gal, making it transmit from person to person rather than from tick to person I would hack into a covid vaccine factory and modify the mRNA code so it produces the spike protein and the alpha-gal protein.

At least then the paranoia about taking the vaccine would be legitimate.

Re: Alpha-Gal Syndrome

#93

Post by sildur »

amluto wrote: post #91
sildur wrote: post #86

Earlier quoted context omitted.

> Side note, here's a free idea for a book: ecoterrorists conduct underground gain-of-function research on Alpha-Gal, making it transmit from person to person rather than from tick to person I would hack into a covid vaccine factory and modify the mRNA code so it produces the spike protein and the alpha-gal protein.

Alpha-gal is a sugar, so this wouldn’t work directly. Also, the syndrome seems to be IgE-mediated, and the mRNA vaccines are intended to induce IgG and perhaps IgA production. So this might not work.

But we could force the cells to produce alpha-gal via mRNA, right? And once the alpha-gal is in the bloodstream, the end result is the same as if it would have been injected by the tick, a immune reaction.

Re: Alpha-Gal Syndrome

#94

Post by wayneftw »

moneywoes wrote: post #88
Diederich wrote: post #16

My wife had this from late 2007 until mid 2009 and nearly died from it. She was one of the early, benchmark cases. We went to Mayo clinic in Rochester in the summer of 2008 and they had no luck identifying her symptoms. An exceptional allergy doctor near our home in Arkansas did endless research and mostly figured out what was going on. After my wife came off of beef in mid 2009 her symptoms completely disappeared. P…

What does her diet look like now? Has her health improved with a meat less diet?I worry if I get this I won't be able to eat much at all, already have celiac disease and lactose intolerance.

My neighbor has this and she said that she can still eat Chicken and Seafood.

Re: Alpha-Gal Syndrome

#95

Post by arcticfox »

Diederich wrote: post #16

My wife had this from late 2007 until mid 2009 and nearly died from it. She was one of the early, benchmark cases. We went to Mayo clinic in Rochester in the summer of 2008 and they had no luck identifying her symptoms. An exceptional allergy doctor near our home in Arkansas did endless research and mostly figured out what was going on. After my wife came off of beef in mid 2009 her symptoms completely disappeared. P…

That's wild - so glad you guys figured it out in time.

What was the process like of narrowing it down first to an allergy, and then to beef (?!)? Was there a protocol in place or was your doctor pretty much improvising?

Re: Alpha-Gal Syndrome

#96

Post by Imnimo »

I'm curious what the probability of contracting the allergy is from a single tick bite? Is it the sort of thing where the chances are low, but if you live in an area or engage in activities where you're getting a lot of bites, your risk is elevated? Or is it the sort of thing where any bite at all carries significant risk?

Re: Alpha-Gal Syndrome

#97

Post by epmaybe »

In school, I once had a patient with this syndrome who was admitted for his anaphylactic reaction - pretty wild. Tick borne diseases in general are fairly fascinating.

We joke about which antibiotic we would like to have if stuck on an island, and I always go with doxycycline.

Re: Alpha-Gal Syndrome

#98

Post by amluto »

sildur wrote: post #93
amluto wrote: post #91

Earlier quoted context omitted.

Alpha-gal is a sugar, so this wouldn’t work directly. Also, the syndrome seems to be IgE-mediated, and the mRNA vaccines are intended to induce IgG and perhaps IgA production. So this might not work.

But we could force the cells to produce alpha-gal via mRNA, right? And once the alpha-gal is in the bloodstream, the end result is the same as if it would have been injected by the tick, a immune reaction.

Seems unlikely. Read the review article linked elsewhere:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554561/

Alpha-Gal syndrome is characterized by IgE (allergic) antibodies, and the mechanism that induces them is complicated. Merely putting an antigen into your body doesn’t do it.

Re: Alpha-Gal Syndrome

#100

Post by sildur »

amluto wrote: post #98
sildur wrote: post #93

Earlier quoted context omitted.

But we could force the cells to produce alpha-gal via mRNA, right? And once the alpha-gal is in the bloodstream, the end result is the same as if it would have been injected by the tick, a immune reaction.

Seems unlikely. Read the review article linked elsewhere: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554561/ Alpha-Gal syndrome is characterized by IgE (allergic) antibodies, and the mechanism that induces them is complicated. Merely putting an antigen into your body doesn’t do it.

Ah, now I understand. Yes, it's more complex than simply having alpha-gal in your bloodstream.
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