So this past year the government has been willing to let unemployment, suicides and drug overdoses jump due to isolation and loneliness caused by lockdowns, child abuse to skyrocket and mental health to plumment due to schools being kept closed, all because we needed to stop covid at any cost. Now one person dies out of almost 7 million who received the vaccine, and we need to stop administering the J&J vaccine "out of an abundance of caution"? I'm starting to think more and more that the shitty decisions regarding covid in the past year were because it was an election year.
US agencies call for pause in Johnson & Johnson vaccine
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Re: US agencies call for pause in Johnson & Johnson vaccine
#92I just made this website to show you how really, really small the risks are, and how they compare to risks we happily take every single day. whatoneinamillionmeans.com If you're not willing to take 1 in a million chances, it's gonna be pretty hard for you to get out of bed today. This vaccine seems to have about the same rate, which makes sense as I think it uses the same technology.
I appreciate what you’re doing but I’m still avoiding the vaccine as long as I can. I’ve got a class 1 medical , a PPL and I hope [ha] one day to get paid to fly planes. I really don’t want another Pandemrix because with my luck I’d end up with the side effect. Also I’m MASSIVELY allergic to certain drugs and I get the NHS third choice for antibiotics and anti inflammatories.
Re: US agencies call for pause in Johnson & Johnson vaccine
#93Earlier quoted context omitted.
Maybe. In a lot of places you don't really have a choice and, in the US, AFAIK the mRNA vaccines are more common. Also, while "vaccine passports" have started being discussed, they're not really a factor yet--given how many people still need to vaccinated--and may never be outside of scenarios like schools. (That said, I have heard people who see getting a vaccine as more pro forma saying they prefer J&J because it's…
It's pretty easy to "vaccine shop" (if you care about it) at least in the US with all of the scheduling being done online. Sure, if you go to one of the big vaccination sites, you may not get a choice, but it seems that sites offering J&J have been advertising that and ones that don't indicate seem to be Pfizer & Moderna (or if J&J, give you a choice, at least around Massachusetts). J&J is also widely used in the US…
Fair enough. It was still quite hard to get one when I scheduled and I was going to take whatever I could get even if I favored the mRNA ones. That said, if I didn't really care about getting a vaccine but was going to get one anyway, I'd probably just choose whatever I could get most easily.
Re: US agencies call for pause in Johnson & Johnson vaccine
#94Earlier quoted context omitted.
> Important question is why we unable to scale up production of mRNA vaccines? Where are you getting the idea that we can't? Hundreds of millions of doses of the Pfizer and Moderna vaccines have already been made. Pfizer expects to make 2 billion doses this year.
Why only this 2 companies? Why don't we mobilize all pharma of the world to produce more mRNA vaccines quickly? Intellectual property? I think it's an extraordinary time so we should all agree to vaccinate all earthlings quicker is much higher priority than commercial interests.
Again, where are you getting the idea that this isn't being done?
https://www.novartis.com/news/media-releases/novartis-signs-...
> Novartis announced today that it has signed an initial agreement to leverage its manufacturing capacity and capabilities in order to address the COVID-19 pandemic by supporting the production of the Pfizer-BioNTech COVID-19 Vaccine. The agreement will see Novartis utilizing its aseptic manufacturing facilities at its site in Stein, Switzerland.
https://www.merck.com/stories/why-were-excited-to-partner-on...
> On March 2, we announced a partnership with Johnson & Johnson to expand manufacturing capacity and supply of its COVID-19 vaccine. Under the Biomedical Advanced Research and Development Authority (BARDA) agreement, our company is adapting and making available some of our existing manufacturing sites to accelerate manufacturing efforts for the vaccine and enable more timely delivery and administration.
https://investors.modernatx.com/news-releases/news-release-d...
> Under the terms of the agreement, the companies plan to establish manufacturing suites at Lonza’s facilities in the United States and Switzerland for the manufacture of mRNA-1273 at both sites. Technology transfer is expected to begin in June 2020, and the companies intend to manufacture the first batches of mRNA-1273 at Lonza U.S. in July 2020.
https://www.astrazeneca.com/media-centre/press-releases/2021...
> AstraZeneca and IDT Biologika also intend to strengthen Europe’s vaccine manufacturing capability with a joint investment to build large additional drug substance capacity for the future. Details of the agreement are to be finalised. Both companies plan to invest in capacity expansion at IDT Biologika’s production site in Dessau, Germany to build up to five 2,000-litre bioreactors capable of making tens of millions of doses per month of AstraZeneca’s COVID-19 vaccine. The new assets are estimated to be operational by the end of 2022.
Re: US agencies call for pause in Johnson & Johnson vaccine
#95Earlier quoted context omitted.
Paraphrasing one famous science commenter, we're playing Pandemic Trolley Problem and running over hundreds of people because we're not sure if the other path has one or two persons. It's ridiculous. Or as per someone that actually knows statistics: https://twitter.com/NateSilver538/status/1381925025964515330
It may be ridiculous, but it seems necessary if you're managing populations of people: Build a dam, which if it broke would kill hundreds-of-thousands, or let millions die for lack of water? Oh, we'll just over-engineer it, now we can't afford to buy food to keep the people alive long enough to need the dam; or the lead engineering firm embezzles the money and installs dodgy iron. We can't wait around for long term s…
You're blowing the problem out of proportion
Deaths by Covid are still much more likely than deaths by the vaccine.
Hospitalizations as well, except for the 20-29 cohort https://twitter.com/VikiLovesFACS/status/1379833789334089734
Re: US agencies call for pause in Johnson & Johnson vaccine
#96Earlier quoted context omitted.
> Important question is why we unable to scale up production of mRNA vaccines? Where are you getting the idea that we can't? Hundreds of millions of doses of the Pfizer and Moderna vaccines have already been made. Pfizer expects to make 2 billion doses this year.
Why only this 2 companies? Why don't we mobilize all pharma of the world to produce more mRNA vaccines quickly? Intellectual property? I think it's an extraordinary time so we should all agree to vaccinate all earthlings quicker is much higher priority than commercial interests.
intellectual property is one reason[1] but for the mRNA vaccines, the technology/machinery required to mass produce them is also part of the bottleneck along with raw materials[2]
1. https://theconversation.com/how-patent-laws-get-in-the-way-o...
2. https://www.thedailybeast.com/heres-why-it-will-be-hard-to-r...
Re: US agencies call for pause in Johnson & Johnson vaccine
#97Earlier quoted context omitted.
> We know that there are no side effects that are common enough to be of real concern How did they establish that there are no long term side effects?
Not a doctor, but from what I've heard from immunologists, vaccines in general are incredibly unlikely to have long-term side effects on the scales that you think about. When an immunologist talks about "long-term side effects" of a vaccination, they're usually considering time ranges on the order of 6-8 weeks. Meanwhile, the 10000s of patients from the big Phase 3 trials have been vaccinated for 6-9 months, so the u…
The only reason we think that is because vaccines in the past have had most of their recorded side effects present in the first few weeks.
Past performance...
Re: US agencies call for pause in Johnson & Johnson vaccine
#98Earlier quoted context omitted.
There's about 1/250,000 risk of clots, but they are treatable. In the UK there's been 19 people die after ~20 million vaccinations.
That’s assuming J and J has same incidence as AZ. J and J so far has had 6 clots for seven million doses. Of course some more may show up in coming days from prior vaccinations.
One caution here; at least with AZ, apparent rate of clots varied dramatically by country, and rates generally went up once people knew what they were looking for. It's plausible that a lot of early ones were missed entirely or misattributed.
Re: US agencies call for pause in Johnson & Johnson vaccine
#99Earlier quoted context omitted.
Not a doctor, but from what I've heard from immunologists, vaccines in general are incredibly unlikely to have long-term side effects on the scales that you think about. When an immunologist talks about "long-term side effects" of a vaccination, they're usually considering time ranges on the order of 6-8 weeks. Meanwhile, the 10000s of patients from the big Phase 3 trials have been vaccinated for 6-9 months, so the u…
The only reason we think that is because vaccines in the past have had most of their recorded side effects present in the first few weeks. Past performance...
... is a pretty decent indicator in this case.
Vaccines are not the stock market. No one doubts gravity because "past performance is not indicative of future results".
Re: US agencies call for pause in Johnson & Johnson vaccine
#100I just made this website to show you how really, really small the risks are, and how they compare to risks we happily take every single day. whatoneinamillionmeans.com If you're not willing to take 1 in a million chances, it's gonna be pretty hard for you to get out of bed today. This vaccine seems to have about the same rate, which makes sense as I think it uses the same technology.
I appreciate what you’re doing but I’m still avoiding the vaccine as long as I can. I’ve got a class 1 medical , a PPL and I hope [ha] one day to get paid to fly planes. I really don’t want another Pandemrix because with my luck I’d end up with the side effect. Also I’m MASSIVELY allergic to certain drugs and I get the NHS third choice for antibiotics and anti inflammatories.
Everyone should make their own decisions. I'm just trying to put out some truth about the risks so people can make informed choices.
TBH I've made this site for myself as much as anyone - I'm just under 40 so the risk/benefit is tight for me personally, but I want to do my bit for everyone else and stop the spread so I'll take any vaccine they'll give me.
Good luck with you flying dreams and say safe!