Live data from Hacker News

Suppressing a gene by using its antibody can lead to tooth growth: animal study

u-fukui.ac.jp

91–100 of 163 posts

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#91

Earlier quoted context omitted.

Just pull all teeth and let them regrow at the same time, of course. Next!

I know you're joking but theres actually people who would pray for a treatment exactly like this. The elderly in particular. Over time all your teeth go. When I'm 60 I wouldnt mind them just ripping them all out if I could regrow them in 3 months.

I would pay for this and I am 33 and have 5 root cannals fixed. Maybe 3 tooth without fillings. It runs in our family... I also didn't have the best dentists growing up in eastern block. Almost no rentgen on basic fillings or microscope on root cannals, only amalgam filling except front tooth. Now I am in process of redoing badly done fillings with cavities under fillings. Al so I have two teeth taken out because my dentist didnt properly explained to me they could be fixed... If I lived in the middle ages, I would look like a 60 year old with no teeth.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#92
Although amazing, I am following similar news for last 20 years, and promise of tooth regrowth was as a holly grail of dental health, but on the other side it is similar like a nuclear fusion always 20 years away. Process goes like this, "big news -> excitement -> and then nothing -> few years later again nothing -> you go to you dentist for regular check and when you ask he laughs in your face."

I read about steam cell re-growth, electric arc repair, calcium filaments instead of "plastic" composts ... and nothing came into fruition. If it ever gets to the market probably I will not need teeth anymore.

In this type of economic environment why would dentists allowed everyone to have perfectly healthy teeth? This type of product may succeed only if someone decides to go rogue like Tesla with electric cars, deliberately impacting competitors ...

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#93
these guys found a polypeptide that can repair enamel but they aren't very well known https://www.curodont.com/ edit: correct link for the enamel thingie is this -> https://www.curodont-professional.com/. I remember seeing some papers from them justifying this, but cant' find them

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#94

Although amazing, I am following similar news for last 20 years, and promise of tooth regrowth was as a holly grail of dental health, but on the other side it is similar like a nuclear fusion always 20 years away. Process goes like this, "big news -> excitement -> and then nothing -> few years later again nothing -> you go to you dentist for regular check and when you ask he laughs in your face." I read about steam c…

As a general rule, the entire medical profession has the incentives set up the wrong way - the more problems you have, the more they benefit.

I have read that there was a time, in the distant past, where you paid a doctor only as long as you were healthy. I can come up with some problems even in that case, but I can't help but think it might still be an improvement over the current situation...

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#95

Whatever progress it may provide, I am certain that dentists and dentists' associations will slowly and surely entomb any process that reduces the sum of their individual annual incomes. I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

> I believe Adam Smith called it "the invisible hand" (w/o explicitly noting that the "invisible boot" is jammed into the "invisible customers"' collective asses).

It is useful to actually read what Adam Smith said and understand it[1]. In fact, I thoroughly recommend reading Ricardo, Mill, Knight, Hayek, Keynes, and von Mises to understand the important conceptual battlegrounds in the history of economic thought.

Smith's problems were mostly about confusing value and price (and thinking there is a well defined, universal "the value" of something -- in this he is joined by Ricardo. Marx merely took those ideas and confused himself due to his lack of knowledge of linear algebra).

Note by "corporation" below, he is referring to trade associations. He is arguing, at the same time, against both licensing requirements AND subsidies for education at the same time (among other things).

He understood the nature of what you call the "invisible boot".

> People of the same trade seldom meet together, even for merriment and diversion, but the conversation ends in a conspiracy against the public, or in some contrivance to raise prices. It is impossible, indeed, to prevent such meetings, by any law which either could be executed, or would be consistent with liberty and justice. But though the law cannot hinder people of the same trade from sometimes assembling together, it ought to do nothing to facilitate such assemblies, much less to render them necessary.

> A regulation which obliges all those of the same trade in a particular town to enter their names and places of abode in a public register, facilitates such assemblies. It connects individuals who might never otherwise be known to one another, and gives every man of the trade a direction where to find every other man of it.

> A regulation which enables those of the same trade to tax themselves, in order to provide for their poor, their sick, their widows and orphans, by giving them a common interest to manage, renders such assemblies necessary.

> An incorporation not only renders them necessary, but makes the act of the majority binding upon the whole. In a free trade, an effectual combination cannot be established but by the unanimous consent of every single trader, and it cannot last longer than every single trader continues of the same mind. The majority of a corporation can enact a bye-law, with proper penalties, which will limit the competition more effectually and more durably than any voluntary combination whatever.

> The pretence that corporations are necessary for the better government of the trade, is without any foundation. The real and effectual discipline which is exercised over a workman, is not that of his corporation, but that of his customers. It is the fear of losing their employment which restrains his frauds and corrects his negligence. An exclusive corporation necessarily weakens the force of this discipline. A particular set of workmen must then be employed, let them behave well or ill. It is upon this account that, in many large incorporated towns, no tolerable workmen are to be found, even in some of the most necessary trades. If you would have your work tolerably executed, it must be done in the suburbs, where the workmen, having no exclusive privilege, have nothing but their character to depend upon, and you must then smuggle it into the town as well as you can.

> It is in this manner that the policy of Europe, by restraining the competition in some employments to a smaller number than would otherwise be disposed to enter into them, occasions a very important inequality in the whole of the advantages and disadvantages of the different employments of labour and stock.

> Secondly, the policy of Europe, by increasing the competition in some employments beyond what it naturally would be, occasions another inequality, of an opposite kind, in the whole of the advantages and disadvantages of the different employments of labour and stock.

> It has been considered as of so much importance that a proper number of young people should be educated for certain professions, that sometimes the public, and sometimes the piety of private founders, have established many pensions, scholarships, exhibitions, bursaries, etc for this purpose, which draw many more people into those trades than could otherwise pretend to follow them. In all Christian countries, I believe, the education of the greater part of churchmen is paid for in this manner. Very few of them are educated altogether at their own expense. The long, tedious, and expensive education, therefore, of those who are, will not always procure them a suitable reward, the church being crowded with people, who, in order to get employment, are willing to accept of a much smaller recompence than what such an education would otherwise have entitled them to; and in this manner the competition of the poor takes away the reward of the rich.

[1]: https://www.gutenberg.org/files/3300/3300-h/3300-h.htm

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#96
post #41
post #31

Earlier quoted context omitted.

It's so sad that most dentists optimise for billable revenue, even at the detriment of long term patient health. Fillings for example always degrade and need repairs after X years. Drilling and filling even the smallest cavity puts that teeth on a lifetime progression to bigger and bigger fillings, eventually a root canal, eventually an implant. Cavities, on the other hand can be arrested (stopped), and if small can…

Novamin toothpaste has been life changing for me. Cannot recommend highly enough. A tooth that was deteriorating and the dentist wanted to cap is now fine enough for them to simply keep an eye on.

Have you checked out Biomin? It’s meant to be an improved version of Novamin.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#97
post #46
post #33

Earlier quoted context omitted.

I don't know. We see pharma companies killing one-time cures to not cannibalise recurring treatments, even if another company makes the recurring treatments.

Where have we seen this? Genuine question.

Anecdotal, but I heard it from a reasearcher working in pharma that the company stopped developing a drug that cured some condition that another branch of the company had a treatment for.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#98

Although amazing, I am following similar news for last 20 years, and promise of tooth regrowth was as a holly grail of dental health, but on the other side it is similar like a nuclear fusion always 20 years away. Process goes like this, "big news -> excitement -> and then nothing -> few years later again nothing -> you go to you dentist for regular check and when you ask he laughs in your face." I read about steam c…

As a general rule, the entire medical profession has the incentives set up the wrong way - the more problems you have, the more they benefit. I have read that there was a time, in the distant past, where you paid a doctor only as long as you were healthy. I can come up with some problems even in that case, but I can't help but think it might still be an improvement over the current situation...

there was a time, in the distant past, where you paid a doctor only as long as you were healthy

This sounds implausible, and even if it were true it would not be very fair: it's usually not the doctor's fault when you've got some medical issue, so why should s/he suffer from that financially?

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#100
post #41

Earlier quoted context omitted.

Novamin toothpaste has been life changing for me. Cannot recommend highly enough. A tooth that was deteriorating and the dentist wanted to cap is now fine enough for them to simply keep an eye on.

I have never heard of this Novamin toothpaste before. Nor has any of my dentists ever recommended it. It looks like the popular brand is Sensodyne.

I never heard of Novamin, but I used Sensodyne for years becase it tastes better.
Post reply on HN