Earlier quoted context omitted.
This is still possible using JavaScript, and yet it is not widely seen. You can think of WebAssembly as another mechanism for executing code in the browser in the context of a web page. JavaScript is still required to (1) load the wasm binary, (2) evaluate it and (3) connect it to DOM APIs or really anything outside of the isolated wasm execution context.
How you block some forms of tracking/ads is you inject your own STUB javascript functionality before the offending script loads. https://github.com/uBlock-user/uBO-Scriptlets This wont work with webassembly.
executesitefunction.js could arguably be effected, but that relies on a site installing a particular function on window, which isn't required when using JS, and could be still done where the function is backed by WASM