Earlier quoted context omitted.
It is hard to imangine that smart people in the other solar system won't figure things out. The physics of nuclear is mostly known, which is why Iran and North Korea can have nuclear programs despite efforts to stop it. Anything secret that is exported to a different solar system is reverse engineerable. The first colonists will of course need to bring stuff with them, but it doesn't make sense to assume they won't p…
> The first colonists will of course need to bring stuff with them IMHO, first thing sent will be a universal Assembler, which will produce stuff and clone colonists. If a woman can give birth to a baby in 9 months, we can create a "3D printer" which will self assemble other "3D printers", which then produce mechanisms, computers, and colonists.
The "protomolecule" from the Expanse series is an even more effective if frightening version of the idea, an interstellar virus that hijacks any local biochemistry to bend it to its purposes.