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Psilocybin found safe for consumption in largest ever controlled study

independent.co.uk

91–100 of 236 posts

Re: Psilocybin found safe for consumption in largest ever controlled study

#91
post #78
post #66

Earlier quoted context omitted.

I would argue that if they don't trust aspirin, they should buy a kit that lets them make aspirin (or salicin, rather) at home from willow bark. Still safer than consuming arbitrary unknown amounts of salicin, together with whatever else is in the bark besides salicin. Let me put it this way: the big-pharma drug manufacturing (and more generally, medical-equipment manufacturing) pipeline is set up such that the only…

> heavy-metal soil toxicity; by pesticides; by coincidental allergens in non-active-ingredient plant matter The exact same risks are in your grocery store produce aisle. I'll grant that illegal marijuana has higher risk, but if it's regulated like any legal food crop I don't see the difference; in fact, I'd say there's less, since people consume it in relatively low quantities.

...which is precisely why hospital food is just as processed as drugs are, to remove those variables.

Doctors know there's a certain number of X-factors a patient can't avoid (like e.g. eating food from random sources if they're not under in-patient care) but they don't want to introduce new ones if they can help it.

Another analogy: a doctor will never prescribe you "a supplement." They might tell you getting more vitamin B in your diet would be good, but they'll never tell you to go out and buy a vitamin-B complex supplement. If they think you really need vitamin-B in a pill, they'll prescribe an actual big-pharma-pipeline-produced pill containing vitamin B.

Why? Because who-the-heck knows what's in the random supplement you bought off Amazon is why. If the pharmacy says they got a pill from big-pharma mfgr X, and mfgr X says they produced it (and the FDA endorses mfgr X), then that's a chain of custody and a chain of responsibility that holds them to account, and so ensures that there really is vitamin B (and nothing else) in the pill. That means you're not getting any extra risks just from taking the pills, beyond some weird interaction between you and vitamin B. Whereas, those supplement pills from Amazon? Nobody checked those. Your doctor does not want you to take random unchecked pills that may or may not contain vitamin B, and may-or-may-not contain lead/mercury/cyanide/whatever. They want you to take pills that certainly do contain vitamin B, and certainly don't contain those other things. Thus, prescriptions; thus, pharmacies; thus, the FDA itself.

Re: Psilocybin found safe for consumption in largest ever controlled study

#92
post #90

Earlier quoted context omitted.

> I'm a skeptic that 1. CBD+THC offers any additional medical† benefits over CBD used alone You shouldn't be, because empirical evidence shows that there are. CBD's most overt therapeutic effect is mediated through action at 5HT1A autoreceptors and allosteric modulation of mu and delta-opioid receptors, whereas THC's MoA is mediated through CB1 agonism, to a lesser extent CB2 agonism, and to a lesser extent than CBD,…

I agree with everything you said, but you didn't say anything that relates to medical benefits of THC for any specific use-cases. Certainly CBD+THC has synergistic effects—it gets you more high —but does it relieve more pain , or fight more nausea ? Because those are the criteria the treatment is being graded on here. I'm not skeptical that THC does anything; it certainly does. What I'm skeptical of, is whether marij…

> I agree with everything you said, but you didn't say anything that relates to medical benefits of THC for any specific use-cases.

I did, though I wasn't explicit. CBD has no discernible effect on CB1 receptors, and produces no anti-emetic effect. THC's CB1 agonism is directly responsible for its strong anti-emetic effect. CB1 agonism also has effects on pain perception and processes in the gut.

CBD has no discernible effect on CB2 receptors, while THC does. CB2 agonism is responsible for effects on immune system, inflammation via autoimmune responses and inflammation in the GI tract associated with IBS, Crohn's and UC.

Re: Psilocybin found safe for consumption in largest ever controlled study

#93

The study seems to be this one: https://doi.org/10.3389/fphar.2017.00974 Would it kill the PopSci article to include the DOI to the actual study?

Possibly of interest to others

> Post capsule ingestion, patients lay with eyes closed and listened to music pre-selected by the research team (Kaelen et al., 2017) (https://www.mixcloud.com/MendelKa/playlists/psilocybin-v13/).

Re: Psilocybin found safe for consumption in largest ever controlled study

#94
post #6

I'm personally excited to see what sorts of new treatments will come out of using psychedelics medically. I've always been on the skeptical side of medical marijuana usage in all but the most extreme cases, but I have a feeling that LSD and psilocybin can really provide mental turning points and help people break out of depression.

> I've always been on the skeptical side of medical marijuana usage in all but the most extreme cases, Really? I've always found the milder claims fairly believable (fighting nausea or chronic low level pain relief). As an anecdote, I can attest to dealing with kidney stone pain well (rather than stopping the pain it reduced how much I noticed it) and it ended up more effective and felt less dangerous than the opiods…

[deleted]

Re: Psilocybin found safe for consumption in largest ever controlled study

#95
post #73

Earlier quoted context omitted.

Hydroponic cannabis is grown in highly controlled environments and the dosage levels are tested to be within an acceptable range. There are also dozens (hundreds) of other cannabinoids found in marijuana which (may) have additional medical benefits. >It's like prescribing willow bark for a headache when aspirin exists. Willow bark contains salicin, not aspirin, while marijuana contains both THC and CBD. Willow bark a…

My point was more, "measurement good; eating psychoactive things off the ground bad." The "key advancement of chemistry"—the thing that makes chemistry chemistry , rather than alchemy (and as it happens, the thing that differentiates baking from cooking) is being able to measure the reactants we put into a beaker, and clean the product of the reaction of any side-products, such that we can then crystallize/distill/et…

Pills let a doctor reasonably guess that that the prescription will have expected results. When you get to psychiatric medicine it is a well-funded and socially approved game of wheel of fortune, e.g., https://www.verywellmind.com/antipsychotic-medications-black...

Re: Psilocybin found safe for consumption in largest ever controlled study

#96

I'm personally excited to see what sorts of new treatments will come out of using psychedelics medically. I've always been on the skeptical side of medical marijuana usage in all but the most extreme cases, but I have a feeling that LSD and psilocybin can really provide mental turning points and help people break out of depression.

Sativa-dominant strains have psychedelic qualities, offering dramatic introspective, frame-shifting experience. It isn't as profound an experience as one from psilocybin, but that's not necessarily a bad thing. I've experienced realizations while under the influence of sativa dominant strains similar to, if not greater than, those uncovered during therapy with a psychologist. However, other times the re-framing of reality was simply fiction or not as epic as what it felt like while under the influence. Since the experience is so introspective for me, I partake in it sparingly, in the right settings where I can get the most medicinal value from it.

Re: Psilocybin found safe for consumption in largest ever controlled study

#97
post #48

Earlier quoted context omitted.

I'm very optimistic as well. My family has hard-to-treat depression and there's a lot of reason to be optimistic about psilocybin. Michael Pollan's "How to Change Your Mind" was a fantastic read. It only makes me wonder what other possibilities have been out there but banned and therefore unavailable for study and experimentation. Luckily the days of censoring and hoarding information seem to be coming to an end. Of…

Magic mushrooms were the first substance to make me feel like myself after years and years of deep depression. But I didn't get quite the one hit, life changing state of mind that is often attributed to psychedelics. One thing that I have read is that the whole life-changing thing requires a transcendental experience - and that participants who failed to reach that echelon didn't experience long term improvement. I c…

Back in the day we'd make a chocolate shake and blend 'em in.

Re: Psilocybin found safe for consumption in largest ever controlled study

#100

Don't rush out and take mushrooms. If you're not taking it in a clinical setting, you're doing it wrong.

> If you're not taking it in a clinical setting, you're doing it wrong.

I'd be interested to see some support for this statement.

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