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Hepatitis C kills more Americans than all other infectious diseases combined

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Re: Hepatitis C kills more Americans than all other infectious diseases combined

#91
post #8

Earlier quoted context omitted.

There’s a $300 treatment on the way: https://www.dndi.org/2018/media-centre/press-releases/new-af...

or go to India now and be treated for $1k [1]? [1] https://www.medicaltourismmag.com/article/hepatitis-c-treatm...

It’s basically to the point where it’s:

> Go to and be treated for

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#92

This is likely going to be an unpopular question and maybe I m just really naive, but is the protein really so complex to synthesize that a kit could not be made to make a small batch at home? I ask this because I have recently been studying what is required to produce non naturally occurring amino acids and while not trivial, it can be done. Are there not biohackers that figure these things out as a hobby? I know, t…

I paid $1300 for a 12 weeks course of generic Harvoni from India. I paid using credit card and it arrived within a week. Normally I'm a law-abiding citizen, but as you said, if it comes down to choosing between violating intellectual property laws and death, it's an easy choice to make.

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#93

Earlier quoted context omitted.

Most Americans wouldn't end up paying the 84k. Their insurance would pay for most of that, and negotiate it down further - the other day I was picking up a drug that without insurance would cost over $1,000. I paid $34.

Insurance is something you pay on all year long, you will eventually pay the 84k and more.

sure - let's say you pay your own insurance, which most people do not do - let's also say you pay an average of $5,500 a year for it, and have insurance from age 26 to 72 - that's 46 years. So you have now spent $253,000 over your lifetime, which is definitely above the 84k.

If you only have one disease or hospitalization in your life, however, you're rare - this is also extremely unlikely given your chronic Hep C. As an example, the average cost per person in the US, including healthy people, is $10,000 a year, 4,500 more than your insurance cost.

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#95

Earlier quoted context omitted.

In many other countries getting treated for hepatitis C won't cost you a dime besides your regular health insurance payment. Prices are often negotiated by health insurers and are pretty much guaranteed to be lower for that reason. Depending on what system you are in, you might never even learn what your treatment cost. Not that you should care.

That depends on the treatment and politicians’ willingness to pay for it. Take cystic fibrosis in England: Until this year, modern, highly effective (and, yes, expensive) treatments available for years in the US—covered at low out-of-pocket cost by insurers there—were unavailable through the NHS.

The exception or the rule?

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#96
post #89
post #15

Earlier quoted context omitted.

They're priced this way because they're 80-90% cheaper than the previous treatment. Previously, with no cure, HepC patients would have eventually had a liver transplant. Liver transplants cost between $500K-$1M. Of course, it also requires a liver, so many would die waiting for a liver. As you noted, the drugs have become much cheaper. Mavyret is ~1/2 the cost of Sovaldi, the first drug on the market (replaced by Har…

Pro-tip: it doesn't actually cost $500K-1M to transplant a liver (which you get for free).

Do you have a source for this?

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#97
post #3
post #2

Antiviral drugs for hepatitis C are very effective, but they come at a steep cost. Just one Sovaldi pill costs $1,000. A full 12-week course of treatment with this drug costs $84,000. The price of other hepatitis C drugs is also high: Harvoni costs $94,500 for a 12-week treatment Mavyret costs $39,600 for a 12-week treatment Zepatier costs $54,600 for a 12-week treatment Technivie costs $76,653 for a 12-week treatmen…

Jesus how much did these drugs cost to develop? Are these numbers justified?

[deleted]

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#98
post #3

Earlier quoted context omitted.

Jesus how much did these drugs cost to develop? Are these numbers justified?

The development costs per a Forbes analysis are as follows: > "The median per-drug R&D spending of companies that developed more than six drugs – that’s only 8 companies – was $5.8 billion." ...so that is $5-6B USD per drug DEVELOPED in large companies. Gilead - maker of Sovaldi/Harvoni for HepC treatment - has been on a development tear of late, and almost certainly falls into that range IMO [2]. For companies that…

I imagine those numbers wouldn't be all that reliable for a bunch of reasons - companies would have vested interests in over or under reporting costs for various reasons, technology progressions mean previously expensive to develop drugs may be cheaper if they were to be redeveloped now, and sample size probably wouldn't be large enough for the raw data to be used when bankrolling pharma research ventures.

Edit: I should contextualise this by noting I have basically no experience with pharma so grain of salt blah blah

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#99
post #2

Antiviral drugs for hepatitis C are very effective, but they come at a steep cost. Just one Sovaldi pill costs $1,000. A full 12-week course of treatment with this drug costs $84,000. The price of other hepatitis C drugs is also high: Harvoni costs $94,500 for a 12-week treatment Mavyret costs $39,600 for a 12-week treatment Zepatier costs $54,600 for a 12-week treatment Technivie costs $76,653 for a 12-week treatmen…

"Harvoni costs $94,500 for a 12-week treatment Mavyret costs $39,600 for a 12-week treatment Zepatier costs $54,600 for a 12-week treatment Technivie costs $76,653 for a 12-week treatment"

I assume that your healthcare covers this. Otherwise cheap imports are available from India, e.g. https://roidgear.net/hepatitis-c

Re: Hepatitis C kills more Americans than all other infectious diseases combined

#100

Earlier quoted context omitted.

Most Americans wouldn't end up paying the 84k. Their insurance would pay for most of that, and negotiate it down further - the other day I was picking up a drug that without insurance would cost over $1,000. I paid $34.

Insurance is something you pay on all year long, you will eventually pay the 84k and more.

In all health insurance, the healthy are subsidizing the sick. If you have Hep C you are costing your insurer a lot more than you're paying them. If you're a very healthy individual and rarely have any issues, you're overpaying by a lot.
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