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Alarming surge in drug-resistant HIV uncovered

nature.com

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Re: Alarming surge in drug-resistant HIV uncovered

#91

Post by bobwaycott »

wsc981 wrote: post #45
mm202018 wrote: post #5

Earlier quoted context omitted.

It’s insane that it is $1400/month out of pocket, and if you have a high deductible plan you’d still be paying $6k+ potentially before it’s covered.

Perhaps more countries should follow Thailand's approach: On January 25, 2007, Thailand’s interim government issued compulsory licenses–which require manufacturers to license generic versions of their patented drugs–for two Western medicines: Kaletra, an advanced anti-AIDS medicine manufactured by Abbott; and Plavix, a blood-thinning treatment to help prevent heart disease, produced by the France-based Sanofi-Aventis…

The above quote, for mobile users:

> On January 25, 2007, Thailand’s interim government issued compulsory licenses–which require manufacturers to license generic versions of their patented drugs–for two Western medicines: Kaletra, an advanced anti-AIDS medicine manufactured by Abbott; and Plavix, a blood-thinning treatment to help prevent heart disease, produced by the France-based Sanofi-Aventis and U.S. firm Bristol-Myers Squibb. These attacks were preceded in November 2006 by a violation of Merck’s patent on the anti-AIDS drug Stocrin.[5] The government threatened to break patents on eleven more drugs.[6] Explaining the rationale behind Thailand’s decision, health minister Mongkol Na Songkhla said that “the move is permissible under international trade rules in the event of national public health emergencies. . . . We have to do this because we don’t have enough money to buy safe and necessary drugs for the people under the government’s universal health scheme.”

Re: Alarming surge in drug-resistant HIV uncovered

#92

Post by roel_v »

mantap wrote: post #87
roel_v wrote: post #79

Earlier quoted context omitted.

It meant (to me) that there are several 'pockets' of this happening simultaneously, it's not some local 'strain' or 'outbreak'. I thought it was a crucial thing to add, for nuance. Not sure why you're so agitated over this.

With the advent of air travel most of these geographically distant places are less than 24 hours away.

...

That can still make them distant? Is Australia less 'distant' from Europe now that it takes 24 hours instead of 6 weeks to get there? In some senses, yes, but not in the sense that the GP used 'distant' (i.e., as a objective word for 'not adjacent').

Re: Alarming surge in drug-resistant HIV uncovered

#93

Post by lm28469 »

nness wrote: post #90
lm28469 wrote: post #77

Earlier quoted context omitted.

Miracle drug with unknown long term side effects* I wouldn't take it unless I was a non monogamous gay man[0], the risks out-weights the benefits in any other demographics imho. [0] not that I have anything against that per say, it's just statistically the most affected demographic

I don't follow your comment; The drug is intended for those people at risk of contracting the disease. Why would you take PrEP if you weren't at risk? (Your also discounting drug users; but unfortunately those addicted and at risk are also the least likely to have the means to acquire the drug.)

Not a day goes by without an article mentioning it in mainstream medias. They rarely mention the target in these articles.

Re: Alarming surge in drug-resistant HIV uncovered

#94

Post by notyourday »

nness wrote: post #90
lm28469 wrote: post #77

Earlier quoted context omitted.

Miracle drug with unknown long term side effects* I wouldn't take it unless I was a non monogamous gay man[0], the risks out-weights the benefits in any other demographics imho. [0] not that I have anything against that per say, it's just statistically the most affected demographic

I don't follow your comment; The drug is intended for those people at risk of contracting the disease. Why would you take PrEP if you weren't at risk? (Your also discounting drug users; but unfortunately those addicted and at risk are also the least likely to have the means to acquire the drug.)

It is not about who the drug is being intended for -- it is about who the drug is being marketed to.

For example there's a massive campaign targeting both men and women engaging in any sort of sexual activity that includes fluid exchange promoting usage of PrEP. One can see it in a subway and on local commercials on TV.

Re: Alarming surge in drug-resistant HIV uncovered

#95

Post by 9HZZRfNlpR »

malandrew wrote: post #39
dillondoyle wrote: post #35

Earlier quoted context omitted.

I can confirm in the US it is truly that expensive (which is fucking crazy). I have pretty good insurance (or at least the best I can get self-buying) but I still have to pay 30% of meds costs. That is something like $400 /month. Luckily Gilled will reimburse up to 7500 /year. Fucked up private insurance in US, they charge that much and then do the reimbursement so they can bill the huge monthly cost to plans / gover…

In the US, we’re paying obscene prices because no other country pays their fair share to recoup the cost of development plus bringing the drug to market plus a reasonable margin for the effort. The US should establish an agreement whereby US patients pay a LOT less but that the foreign patients need to pay the same. The amount the industry earns should be low enough to make it reasonably financially accessible to pat…

Since when the market knows the word fair? You charge as much as you can, in this case Americans are the suckers, but if it makes you feel any better for yourself and natural pride keep calling it as you pay for the whole worlds market.

Re: Alarming surge in drug-resistant HIV uncovered

#96

Post by sgift »

ghostwriter wrote: post #81
iamnotacrook wrote: post #71

Earlier quoted context omitted.

It's hard to imagine nowadays for many people, but ignorant, uninformed opinions like the one you just typed were quite rare before the internet; now they're commonplace. You're not supposed to make up stuff to defend your country, nor to parrot some crap someone else said without thinking about it. You're supposed to think about stuff and make at least a little effort to determine whether something is true, or wheth…

Can you substantiate your rant with facts? The U.S. for decades has been the leading country in drugs r&d and other countries do use the results of it on subsidized terms. https://www.abpi.org.uk/facts-and-figures/science-and-innova...

ABPI - Association of the British pharmaceutical industry. That's not a source, that's propaganda, so we're back to the default: What has been brought up without proof can be dismissed without proof. One reason pharma R&D is higher in the US is that the general costs to bring a product to the US market are far higher than in other countries (e.g. the requirements of the FDA are costlier, see: https://www.sciencedirect.com/science/article/pii/S2452302X1... )

Re: Alarming surge in drug-resistant HIV uncovered

#98

Post by notyourday »

tim58 wrote: post #16
jxramos wrote: post #10

I always felt like the only way you can eliminate the spread of a highly adaptive std is to develop a low barrier on-the-spot test administered just before intercourse at the latest or some point reasonably earlier in a date or whatever. This would still fail under the dormancy period viruses assume but it should improve the odds I'd imagine for those connected in one way or another to promiscuous sexual networks.

1. There is no silver bullet to "eliminate the spread of highly adaptive std" 2. Condoms are very effective and can be used in this type of situation.

> 2. Condoms are very effective and can be used in this type of situation.

Availability of PrEP coincides with a drop in condom usage:

https://www.theguardian.com/society/2018/jun/06/rapid-rise-i...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640310/

Re: Alarming surge in drug-resistant HIV uncovered

#99

Post by notyourday »

gleb wrote: post #31
jxramos wrote: post #10

I always felt like the only way you can eliminate the spread of a highly adaptive std is to develop a low barrier on-the-spot test administered just before intercourse at the latest or some point reasonably earlier in a date or whatever. This would still fail under the dormancy period viruses assume but it should improve the odds I'd imagine for those connected in one way or another to promiscuous sexual networks.

That’s sort of what porn industry does with HIV RNA TMA test. I suspect it’s quite effective.

Porn industry uses an interesting trick:

since all porn talent on all non-underground shoots is supposed to only engage in sex with others (on and off the set) who tested negative and since the new talent has to test negative first time weeks before the talent enters the pool even the look back tests are very effective.

Re: Alarming surge in drug-resistant HIV uncovered

#100

Post by hashmal »

drchewbacca wrote: post #72

Won't all drugs targeted at microbes fail eventually? Surely they create a strong selective pressure which favours the resistant strains. The wider and more frequently the drug is used the faster this process occurs?

The targets have time to become resistant when treatment is misused (wrong dosage, interruption, intermittent use, etc)
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