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Aspirin May Prevent Cancer from Spreading, New Research Shows

scientificamerican.com

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Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#91

Post by kasey_junk »

tptacek wrote: post #15
iplaw wrote: post #14

Earlier quoted context omitted.

I abstain from food between 8PM and 12PM Monday - Friday, adjusting for training schedules and such. It really helps me keep my GI tract clear, reduces inflammation, resulted in weight loss, etc. without any effect on my cycling fitness. IF (or IMF as some people call it) is amazing.

I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)

I've experimented with IF a few times and the big drawbacks for me are I have to choose between eating after I excercise (in the morning) and having dinner with my family.

The former means I'm ravenous the latter is a trade off I don't like for bonding reasons.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#92

Post by wahern »

joshgel wrote: post #82
libdong wrote: post #66

Earlier quoted context omitted.

The maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

In the United States, 325mg is the amount in a single standard OTC pill. People often take two pills because of the old doctor's adage, "take two aspirin and call me in the morning".

81mg is marketed as low-dose (aka "baby aspirin"--because of the size or dose, not because it's intended for babies) and often prescribed as prophylaxis. But that's not particularly relevant wrt the maximum safe short-term dosage. The worst part of a flu usually only lasts a few days.

Here are the label directions from a bottle of generic aspirin as shown on Amazon (GoodSense Aspirin Pain Reliever 325 mg Coated Tablets, 100 Count).

  Drink a full glass of water with each dose. Adults and
  children 12 years and over: take 1 or 2 tablets every 4
  hours or 3 tablets every 6 hours, not to exceed 12 tablets
  in 24 hours. Children under 12 years: consult a doctor.
That's approx. 4 grams/day for OTC usage.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#93

Post by gerdesj »

wahern wrote: post #92
joshgel wrote: post #82

Earlier quoted context omitted.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

In the United States, 325mg is the amount in a single standard OTC pill. People often take two pills because of the old doctor's adage, "take two aspirin and call me in the morning". 81mg is marketed as low-dose (aka "baby aspirin"--because of the size or dose, not because it's intended for babies) and often prescribed as prophylaxis. But that's not particularly relevant wrt the maximum safe short-term dosage. The wo…

So what we have learned here is that whilst many years ago 8-30+ g daily dosage was either routine or at least proscribed in some cases, the routine upper limit is now much reduced because the side effects of taking Salicylate in such huge doses are worse than the symptoms or conditions that it was prescribed for.

However, it may be possible that the stuff might (in huge doses) cure or at least reduce something even worse than its own side effects. Then you are in the realms of a simple risk assessment where the failure mode is pretty horrid but that has to be weighed up against the alternatives if they even exist - all of which ... well you get the idea.

(IANAD)

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#94

Post by jaggederest »

joshgel wrote: post #85
jaggederest wrote: post #53

Earlier quoted context omitted.

That is completely correct. It also has synergistic effects as a pain reliever, but it's mainly there to deter abuse. Of course, addicts have found ways to extract the opiates from the adulterants, so it's not even effective.

Source? Adding it for synergism makes sense and is what I was taught in medical school. I doubt they add it to deter abusers, but I could be wrong...

Just look at the simple fact that they were schedule 3 instead of schedule 2 until 2014, even though the base hydrocodone was schedule 2 without adulterants.

Here's an interesting discussion from 2010, before they were rescheduled

https://painmedicine.oxfordjournals.org/content/11/3/379.ful...

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#95

Post by ZeroFries »

cryptokush wrote: post #78
erikpukinskis wrote: post #10

Because it's anti-inflammatory? Could be confirmation bias, but I keep getting the sense that cancer/immune failure in general is connected to our modern 24/7 eating cycle, without any down time for your body to not be inflamed and work on clearing out bad stuff. Thus life extension from intermittent fasting.

Plant based diets are largely anti - inflammatory and Aspirin is essentially a processed phytonutrient.

Grains are notable exceptions.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#96

Post by JoshMnem »

joshgel wrote: post #82
libdong wrote: post #66

Earlier quoted context omitted.

The maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

The labels on over-the-counter, "adult low dose" aspirin recommend taking up to 48 81mg aspirin tablets (3.9g) per 24 hour period before checking with a doctor to see if that is okay. I was taking up to 1g per day at one point (for pain), thinking that it was a very low dose because of the labels. :/

https://dailymed.nlm.nih.gov/dailymed/image.cfm?id=93682&nam...

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#97

Post by JoshMnem »

iplaw wrote: post #14
erikpukinskis wrote: post #10

Because it's anti-inflammatory? Could be confirmation bias, but I keep getting the sense that cancer/immune failure in general is connected to our modern 24/7 eating cycle, without any down time for your body to not be inflamed and work on clearing out bad stuff. Thus life extension from intermittent fasting.

I abstain from food between 8PM and 12PM Monday - Friday, adjusting for training schedules and such. It really helps me keep my GI tract clear, reduces inflammation, resulted in weight loss, etc. without any effect on my cycling fitness. IF (or IMF as some people call it) is amazing.

That's an interesting idea. I've been on calorie restricting diets non-stop for over a year with good results. My latest experiment is a kind of limited alternate day caloric restriction. I was having great results with full ADF (toggling food intake at 4pm each day), but I started to feel strange after a week or two, so the new diet is a little less extreme. I might try something like your schedule, if the current plan doesn't produce results.

If anyone is experimenting with calorie restriction or intermittent fasting near Berkeley, send me a message via my profile. I'm working on some self-tracking experiments with a group of people.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#98

Post by easilyBored »

salmonet wrote: post #41
benji-york wrote: post #19

Earlier quoted context omitted.

> 8.0–31.2 g per day That is surprising amount of aspirin.

I would go out on a limb and say it's a LOT of Asprin. I usually use "surprising" on HN because anything more specific gets criticized surprisingly often, but that is a ton of asprin

Wild guessing: maybe it contained much less then the xx grams of (pure) aspirin? The rest could have been filler as the tech wasn't as precise as today.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#99

Post by killjoywashere »

noam87 wrote: post #54

(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition…

Erm... that's actually a great book. I'm part-way through it, but set it down a while back because somewhere around chapter 10 I felt like I was up against the law of diminishing returns. If you could happen to get me a page reference, I'd appreciate it.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#100

Post by killjoywashere »

joshgel wrote: post #82
libdong wrote: post #66

Earlier quoted context omitted.

The maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

> I've personally never seen it given more than 325mg daily.

Really? Lortab 5/500?

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