Earlier quoted context omitted.
> An open question independent of the author: What do people use Mathematica for that can't be done in R, SAS, Matlab, SPSS or Python libraries. All those don't offer a seamless environment, that's hassle free, easy to setup, with commercial support, a great GUI, great documentation and works across so many science domains and with different approaches. So, the question is quite (but not that severely) like "what peo…
We (see https://cloud.sagemath.com ) and others (e.g., https://www.continuum.io/ ) do offer commercial support for Python (etc.) and an easy to setup environment. Of course, Matlab is also commercially supported by Mathworks, and it seems that R is now commercially supported by Microsoft ( https://www.microsoft.com/en-us/cloud-platform/r-server ). [Edit: added Microsoft]
Hardly so[1] --especially for general/non-technical users.
[1] http://doc.sagemath.org/pdf/en/installation/installation.pdf