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Magic mushrooms found to lift severe depression in clinical trial

theguardian.com

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Re: Magic mushrooms found to lift severe depression in clinical trial

#91

Post by instakill »

legulere wrote: post #70
sageabilly wrote: post #16

It's great to see the advances in research that are being done around Psilocybin, MDMA, and Ketamine as the results that are coming out look incredibly promising. That being said, godDAMN how in the hell is anyone ever going to take studies like this seriously when they're being reported as "Magic Mushrooms" in Scientific American of all places? This isn't raver kiddies eating dried who-knows-what out of ziplock bags…

That's also why I can't take medical cannabis serious. With medicine you want exact doses and cut all stuff that's potentially giving by-effects. So what you want is e.g. https://en.wikipedia.org/wiki/Nabiximols

That's not how it works though. Many of the people running the cannabis studies have mentioned that the THC or CBD cannabanoids don't work alone. Cannabis has over 100 such cannabanoids. Nobody is definitively certain of the effects of this list outside of the 5 main ones.

So "cutting all stuff that's potentially giving by-effects" is idealistic and not currently possible without reducing the efficacy of the cannabis.

Re: Magic mushrooms found to lift severe depression in clinical trial

#92

Post by elif »

legulere wrote: post #70
sageabilly wrote: post #16

It's great to see the advances in research that are being done around Psilocybin, MDMA, and Ketamine as the results that are coming out look incredibly promising. That being said, godDAMN how in the hell is anyone ever going to take studies like this seriously when they're being reported as "Magic Mushrooms" in Scientific American of all places? This isn't raver kiddies eating dried who-knows-what out of ziplock bags…

That's also why I can't take medical cannabis serious. With medicine you want exact doses and cut all stuff that's potentially giving by-effects. So what you want is e.g. https://en.wikipedia.org/wiki/Nabiximols

There are about 113 cannabinoids in weed, while that pot spray only contains 2. With reefer, exact doses do not matter because unlike most medicine, its active ingredients are endogenous and non-toxic.

I'm sorry that 420 culture causes your bias, but that's not a fault of the plant.

Re: Magic mushrooms found to lift severe depression in clinical trial

#93

Post by fapjacks »

davidw wrote: post #38
sageabilly wrote: post #16

It's great to see the advances in research that are being done around Psilocybin, MDMA, and Ketamine as the results that are coming out look incredibly promising. That being said, godDAMN how in the hell is anyone ever going to take studies like this seriously when they're being reported as "Magic Mushrooms" in Scientific American of all places? This isn't raver kiddies eating dried who-knows-what out of ziplock bags…

> Scientific American My wife got that for a year, and I was quite unimpressed. It's not that detailed, mostly, and there's a lot of not very rigorous editorializing, from what I recall. Also, their 'please renew' campaign was quite deceiptful, sending us some kind of "you owe $$$!!!" notice that was really "you owe $$$ if you want to resubscribe".

It used to be so good back in the early 90s!

Re: Magic mushrooms found to lift severe depression in clinical trial

#94

Post by fapjacks »

elif wrote: post #76
apo wrote: post #62

From the study: > A logical next step would be to carry out a placebo controlled randomised trial in which the level of therapist contact is consistent between conditions. http://www.thelancet.com/pb/assets/raw/Lancet/pdfs/S22150366... Depression studies are subject to well-known, powerful placebo effects, rendering this study's conclusions next to useless: http://blogs.scientificamerican.com/cross-check/are-antidepr…

Heh, a placebo effect would make sense ...to someone that hasn't tripped. The explosion of neurotransmitters can not just be simulated or induced through coercion. There's a chasmic divide between the effects of psilocybin and any mental state you can will consciously or subconsciously. EDIT: unless your hypothesis is that the dissolution of the ego, lack of regard for the conventional, and overwhelming sense of iden…

Right! This made me laugh, the idea of a placebo with magic mushrooms.

Re: Magic mushrooms found to lift severe depression in clinical trial

#95

Post by instakill »

stuxnet79 wrote: post #90

Is there any literature in their efficacy in treating anxiety disorders? As somebody who's suffered from severe anxiety since my mid-teens and had it cleared up more or less from medication I'm extremely interested in seeing how Psilocybin would affect the disorder. I would be quite willing to try it out but I'm very hesitant because I suspect my underlying anxiety would undermine the experience and possibly leave me…

Study on cancer patients showed positive results. http://www.ncbi.nlm.nih.gov/pubmed/20819978

Re: Magic mushrooms found to lift severe depression in clinical trial

#96

Post by ifnaut »

I owe my entire successful career in science and mathematics to repeated use of LSD in my late teens/early 20's. It woke my desire to seek answers to the underlying mechanics of the universe. Before that, I was just a high school drop-out with low self-esteem, no direction, and no positive role models.

Re: Magic mushrooms found to lift severe depression in clinical trial

#97

Post by fapjacks »

stuxnet79 wrote: post #90

Is there any literature in their efficacy in treating anxiety disorders? As somebody who's suffered from severe anxiety since my mid-teens and had it cleared up more or less from medication I'm extremely interested in seeing how Psilocybin would affect the disorder. I would be quite willing to try it out but I'm very hesitant because I suspect my underlying anxiety would undermine the experience and possibly leave me…

Hey, so... I've got pretty severe PTSD from my experiences in combat. Loads of anxiety. I have to tell you since you made this point, that mushrooms specifically have helped me so tremendously to manage the anxiety. The way I describe it to other veterans (to encourage its use among people suffering from these disorders) is that mushrooms help ground me by providing a safe, chill, unique experience that I can later use as a point of reference when my anxiety gets bad. Make sure you know what you are putting into your body, don't take too many, don't eat them in a strange environment (a quiet weekend night in your living room is a good place), and only do mushrooms with someone you know and trust (and who has experience with the experience). You will thank yourself for doing it. It will change your life for the better if you follow those simple guidelines.

Re: Magic mushrooms found to lift severe depression in clinical trial

#98

Post by primitivesuave »

For those seeking to break down the barriers of the mind, psilocybin and mescaline are the most intelligent options. SWIM (Someone Who Isn't Me) grew mushrooms and peyote cactus to enable revelations in the minds of consenting adults, and every single person who ingested these naturally-occurring organic substances thanked SWIM for a life-changing experience.

That said, there are obvious risks to glorifying psychedelic use, especially when available psychedelics are usually in the form of LSD. While these synthetic compounds can yield the same results as their organic counterparts, there is no way to verify the amount of LSD in a dose. Overdosing on LSD can trigger schizophrenia and several other mental problems in those who are prone to it. This is why SWIM recommends organic psychedelic compounds that can be clearly measured into an appropriate dosage for the individual's size and past psychedelic experience.

There is also an overwhelming trend amongst unscrupulous suppliers to market doses of DOC (https://en.wikipedia.org/wiki/2,5-Dimethoxy-4-chloroamphetam...) as LSD. While the observed effect of the two are similar, DOC can be extremely dangerous to those with hypertension and high blood pressure. DOC is also an amphetamine with greater risk of physical addiction.

SWIM also wants to point out that SWIM engaged in countless adventures with varying levels of psilocybin and mescaline dosages, and arrived at the conclusion that psychedelic substances are not necessary for seeing the beauty in life or the purpose that one may have in this world. SWIM's most transformative revelations came about while completely sober at a Taoist monastery of the Wudang mountains in China. It is SWIM's opinion that all can know beauty as beauty only because there is ugliness (Tao Te Ching, chapter 2), and now urges people to pursue safe and well-known techniques (meditation, yoga, tai chi, qi gong) for improving one's state of mind.

Re: Magic mushrooms found to lift severe depression in clinical trial

#99

Post by fapjacks »

mjevans wrote: post #41
protomyth wrote: post #37

Earlier quoted context omitted.

You're right, I don't react better at all. They should stick with saying "THC and related compounds" instead. Its basically the same argument I have for the thorium folks, do not use "reactor" or "nuclear" in any naming or marketing.

Sort of like my own personal stance on 'breeder reactors' being 'waste reduction reactors'. The problem with most of that 'waste' (at least the non-byproducts kind) is that it's exactly that, actual waste instead of burnt fuel.

What about "spent nuclear waste reactors"? It's a big long-winded, but fully conveys that it runs on spent nuclear waste. I suppose it could be parsed weirdly.

Re: Magic mushrooms found to lift severe depression in clinical trial

#100

Post by peterwwillis »

I like how marijuana and psilocybin have no negative side effects and it's taken hundreds of years to be taken seriously as clinical treatments.

Meanwhile, according to the FDA, there were "56,000 emergency room visits, 26,000 hospitalizations, and 458 deaths per year related to acetaminophen-associated overdoses during the 1990s. unintentional acetaminophen overdose accounted for nearly 25 percent of the emergency department visits, 10 percent of the hospitalizations, and 25 percent of the deaths [per year]." [1]

[1] https://en.wikipedia.org/wiki/Paracetamol#Liver_damage

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