861–868 of 868 posts
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Sorry to hear. My doc says to always eat something when taking ibuprofen to protect your stomach.
https://www.drugs.com/medical-answers/you-ibuprofen-empty-st...
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Sorry to hear. My doc says to always eat something when taking ibuprofen to protect your stomach.
Yeah, something like omeprazole.
This isn’t really surprising at all IMO, but it’s nice that it’s been confirmed. > “The researchers believe semaglutide’s anti-aging properties stem from its effects on fat distribution and metabolic health. Excess fat around organs triggers the release of pro-aging molecules that alter DNA methylation in key aging-related genes. By reducing this harmful fat accumulation and preventing low-grade inflammation - both m…
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No, it's not a "behavioral problem." Your phrasing is disgusting. The research is perfectly clear on why it's extrenely difficult to lose weight. There's no need for speculation.
So, you reject thermodynamics? Phrases like "the research" is a convenient way to insinuate and bluff. Obesity is absolutely a behavioral problem.
No.
> Obesity is absolutely a behavioral problem.
Nope.
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They’ve been rewarded enough (~$14.65B USD net profit 2024), and are lucky they’re allowed to capture any further economic benefit from the sale of a simple compound (imho).
... a simple compound that was already developed and in-use, so the current patent (the one that's made it a big, ongoing news story and a kind of social phenomenon) is rewarding only going through the approval process for using it for weight loss, specifically, not development of a new drug.
> In the 1970s, Jens Juul Holst and Joel Habener began research on the GLP-1 hormone [...] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels. However, treating diabetes patients with GLP-1 hormones resulted in significant side effects, leading researchers financed by Novo Nordisk to start looking to develop a suitable compound for therapeutic use. In 1998, a team of researchers at Novo Nordisk led by the scientist Lotte Bjerre Knudsen developed liraglutide, a glucagon-like peptide-1 receptor agonist that could be used to treat diabetes.
GLP-1 is a hormone that naturally occurs in the human body. Novo Nordisk was responsible for turning it into a diabetes medication. They were responsible for turning it into a weight loss medication.
Where are you getting your facts from?
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Losing facial fat will only make you look older if your skin has low elasticity and/or if you lose too much fat, too much fast. Also, it is very common for people that start eating dramatically less to also reduce their water intake too much and become dehydrated. Besides ensuring you're getting sufficient water, there are a lot of dermatologic procedures that can help you to recover at least some of your skin elasti…
Fillers and facelifts also look bad and don’t last
Just wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil… Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss. Ozempic is currently the NVIDIA of the pharmaceutical industry.
> Just wish there weren’t so many false “studies” promoting benefits of medications that have none What’s an example of such a study?
It’s nearly 100 years old and widely used after Pseudoephedrine was more restricted so people couldn’t make meth as easily.
Yet, studies not conducted by pharmaceutical manufacturers find it mostly ineffective. Of course, the drug companies publish studies showing it to be effective…
Have you ever taken each (not together)? I’ve never heard someone say Phenylephrine did anything for them. Anecdotally, it’s utterly useless for me…
I suspect drug companies didn’t want restriction of Pseudoephedrine to decrease sales, so they pushed crap forward to maintain revenue.
(Yes, it still isn’t all that hard to get Pseudoephedrine, but one can’t just pick it off the shelf — a significant mental barrier)
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The underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group
> The underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group Those are causes , you can't just invert it (again) and call them mechanisms for anti-aging... Those things are side effects of obesity and diseases causing obesity, there is no evidence or reasonable basis here to suggest there would be any "anti-aging" effect in healthy people without t…